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Intraarterial Infusion of Lidocaine is Superior to the Subcutaneous Injection of Low Molecular Weight Heparin for Improving the Course of Cerulein-Induced Acute Pancreatitis in Rats Cover

Intraarterial Infusion of Lidocaine is Superior to the Subcutaneous Injection of Low Molecular Weight Heparin for Improving the Course of Cerulein-Induced Acute Pancreatitis in Rats

Archivum Immunologiae et Therapiae Experimentalis
Volume 73 (2025): Issue 1 (January 2025)
By: Ryszard Antkowiak,  Lukasz Antkowiak,  Zbigniew Arent,  Bogna Drozdzowska,  Anna Kasperczuk,  Jacek Bialecki,  Agnieszka Pietsch-Fulbiszewska,  Pawel Domoslawski,  Agata Cieslik-Bielecka and  Marek Kucharzewski  
Open Access
|Apr 2025

Figures & Tables

Fig 1.

Amylase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial amylase levels, M1 – amylase levels after the induction of pancreatitis – just before the operation, M2 – amylase levels 1 h after drug administration, M3 – amylase levels 3 h after drug administration, M4 – amylase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.
Amylase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial amylase levels, M1 – amylase levels after the induction of pancreatitis – just before the operation, M2 – amylase levels 1 h after drug administration, M3 – amylase levels 3 h after drug administration, M4 – amylase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.

Fig 2.

Lipase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial lipase levels, M1 – lipase levels after the induction of pancreatitis – just before the operation, M2 – lipase levels 1 h after drug administration, M3 – lipase levels 3 h after drug administration, M4 – lipase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.
Lipase levels in the NaCl, heparin, and lidocaine–heparin groups over the entire preoperative (M0–M1) and postoperative (M2–M4) course. M0 – initial lipase levels, M1 – lipase levels after the induction of pancreatitis – just before the operation, M2 – lipase levels 1 h after drug administration, M3 – lipase levels 3 h after drug administration, M4 – lipase levels 5 h after drug administration. M0, measurement 0; M1, measurement 1; M2, measurement 2; M3, measurement 3; M4, measurement 4.

Comparison of amylase levels between the control groups

MeasurementMean amylase levels in the NaCl group [U/L]Mean amylase levels in the heparin group [U/L]Mean amylase levels in the lidocaine–heparin [U/L]p-value
NaCl vs. heparinNaCl vs. lidocaine–heparinHeparin vs. lidocaine–heparin
M0644.5708.20658.00.0930.8940.234
M157,083.466,622.047,766.220.4570.4920.069
M233,927.037,428.014,346.890.557<0.001***<0.001***
M320,444.423,452.3011,171.670.4060.002*<0.001***
M412,358.314,504.407914.560.3610.025*0.001**

Comparison of lipase levels between the control groups

MeasurementMean lipase levels in the NaCl group [U/L]Mean lipase levels in the heparin group [U/L]Mean lipase levels in the lidocaine–heparin [U/L]p-value
NaCl vs. heparinNaCl vs. lidocaine–heparinHeparin vs. lidocaine–heparin
M025.9923.1014.670.9090.2670.473
M12502.203236.283077.040.1160.2730.901
M21139.611475.14678.700.1270.032*<0.001**
M3567.48783.49472.910.1710.7120.039*
M4281.98389.79252.210.2800.9070.147

Comparison of histopathological findings between three groups

FeatureNaCl groupHeparin groupLidocaine–heparin groupp-value
Pancreatic tissue
Necrosis0/10 (0%)2/10 (20%)3/9 (33%)0.163
Edema8/10 (80%)6/10 (60%)5/9 (56%)0.530
Hemorrhagic foci0/10 (0%)1/10 (10%)1/9 (11%)0.565
Acute inflammation0/10 (0%)0/10 (0%)2/9 (22%)0.092
Chronic inflammation7/10 (70%)9/10 (90%)9/9 (100%)0.152
Mean number of veins and arteries (SD)19.5 (7.25)17.1 (2.51)15.0 (8.34)0.094
Mean number of capillaries (SD)36.0 (8.76)27.9 (5.65)29.44 (6.35)0.080
Adipose tissue
Necrosis0/10 (0%)0/10 (0%)2/9 (22%)0.092
Hemorrhagic foci0/10 (0%)1/10 (10%)1/9 (11%)0.565
Acute inflammation0/10 (0%)0/10 (0%)1/9 (11%)0.316
Chronic inflammation2/10 (20%)4/10 (40%)6/9 (67%)0.119
DOI: https://doi.org/10.2478/aite-2025-0012 | Journal eISSN: 1661-4917
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Language: English
Submitted on: Dec 11, 2024
|
Accepted on: Mar 3, 2025
|
Published on: Apr 16, 2025
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Experimental,
Microcirculation,
continuous regional arterial infusion,
Vasodilation,
Anticoagulation
Related subjects:
Medicine,
Basic medical science,
Biochemistry,
Immunology,
Clinical medicine,
Clinical medicine, other,
Clinical chemistry

© 2025 Ryszard Antkowiak, Lukasz Antkowiak, Zbigniew Arent, Bogna Drozdzowska, Anna Kasperczuk, Jacek Bialecki, Agnieszka Pietsch-Fulbiszewska, Pawel Domoslawski, Agata Cieslik-Bielecka, Marek Kucharzewski, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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