References
- 1. Baulieu EE, Robel P. Neurosteroids. A new brain function? J. Steoid Biochem. Mol. Biol. 1990; 37(3):S395-403.10.1016/0960-0760(90)90490-C
- 2. Corpéchot C, Synguelakis M, Talha S, Axelson M, Sjövall J, Vihko R et al. Pregnenolone and its sulfate ester in the rat brain. Brain Res. 1983; 270(1):S119-25.10.1016/0006-8993(83)90797-7
- 3. Corpéchot C, Robel P, Axelson M, Sjövall J, Baulieu EE. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc. Natn. Acad. Sci U.S.A. 1981;78(8):S4704-7.10.1073/pnas.78.8.4704
- 4. Selye H. Anesthetic Effect of Steroid Hormones. Proc Soc Exp Biol Med. 1941; 46(1):S116–21.10.3181/00379727-46-11907
- 5. Harrison NL, Simmonds MA. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res. 1984;232(2):S 287-92.10.1016/0006-8993(84)90299-3
- 6. Harrison NL, Vicini S, Barker JL. A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. J neurosci. 1987;7(2):S604-9.10.1523/JNEUROSCI.07-02-00604.1987
- 7. Joksimovic SL, Covey Douglas F, Jevtovic-Todorovic V, Todorovic Slobodan M. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol. 2018;9:S1127.10.3389/fphar.2018.01127617605130333753
- 8. Herzog AG. Intermittent progesterone therapy and frequency of complex partial seizures in women with menstrual disorders. Neurology. 1986;36(12):S1607.10.1212/WNL.36.12.1607
- 9. Herzog AG. Progesterone therapy in women with complex partial and secondary generalized seizures. Neurology. 1995;45(9):S1660-2.10.1212/WNL.45.9.1660
- 10. Joshi S, Kapur J. Neurosteroid regulation of GABA-A receptors: A role in catamenial epilepsy. Brain Res. 2019;1703:S31-40.10.1016/j.brainres.2018.02.031610744629481795
- 11. Monaghan EP, McAuley JW, Data JL. Ganaxolone: a novel positive allosteric modulator of the GABA(A) receptor complex for the treatment of epilepsy. Expert Opin Investig Drugs. 1999;8:S1663-71.10.1517/13543784.8.10.1663
- 12. Reddy DS, Rogawski MA. Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. Epilepsy Res. 2010;89(2-3):S254-260.10.1016/j.eplepsyres.2010.01.009
- 13. Uzunov DP, Cooper BT, Costa E, Guidotti A. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc Natl Acad Sci USA. 1996;93(22):S12599-604.10.1073/pnas.93.22.12599
- 14. Khisti RT, Chopde CT. Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice. Brain Res. 2000;865(2):291-300.
- 15. Eser D, Baghai TC, Schule C, Nothdurfter C, Rupprecht R. Neuroactive Steroids as Endogenous Modulators of Anxiety. Curr. Pharm. Des. 2008; 14(33):S3525-33.10.2174/138161208786848838
- 16. Ičíková M, Dibbelt L, Hiill M, Hampl R, Stárka L. Allopregnenolone in women with premenstrual syndrom. Horm. Metab. Res. 1998;30(4):S227 – 9.10.1055/s-2007-978871
- 17. Ratner MH, Kumaresan V, Farb DH. Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders. Front Endocrinol. 2019;10:S169.10.3389/fendo.2019.00169
- 18. Rahmani B, Ghasemi R, Dargahi L, Ahmadiani A, Haeri A. Neurosteroids: potential underpinning roles in maintaining homeostasis. Gen Comp Endocrinol. 2016; 225:S242-50.10.1016/j.ygcen.2015.09.030
- 19. Melcangi RC, Giatti S, Pesaresi M, Carabrese D, Mitro N, Caruso D et al. Role of Neuroactive Steroids in the Peripheral Nervous System. Front Endocrinol. 2011;2:S104.10.3389/fendo.2011.00104
- 20. Melcangi RC, Garcia-Segura LM, Mensah-Nyagan, AG. Neuroactive steroids: State of the art and new perspectives. Cell. Mol. Life Sci. 2008;65(5):S777-97.10.1007/s00018-007-7403-5
- 21. Mellon SH, Griffin LD. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol. Metab. 2002;13(1): S35-43.10.1016/S1043-2760(01)00503-3
- 22. Baulieu EE, Robel P, Schumacher M. Neurosteroids: Beginning of the story. Int. Rev. Neurobiol. 2001;46:S1-32.10.1016/S0074-7742(01)46057-0
- 23. Liu J, Rone MB, Papadopoulos V. Protein-Protein Interactions Mediate Mitochondrial Cholesterol Transport and Steroid Biosynthesis. J Biol Chem. 2006;281(50):S38879-93.10.1074/jbc.M60882020017050526
- 24. Caleb BK, Billheimer TJ, Summers SA, Stayrook SE, Lewis M, Strauss FJ. Steroidogenic Acute Regulatory Protein (StAR) Is A Sterol Transfer Protein. J Biol Chem. 1989;273(41):S26285-88.10.1074/jbc.273.41.262859756854
- 25. Bose M, Whittal RM, Miller WL, Bose HS. Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein, J Biol Chem. 2008;283(14):S8837-45.10.1074/jbc.M709221200227637518250166
- 26. Selvaraj V, Stocco DM. The changing landscape in translocator protein (TSPO) function. Trends Endocrinol. Metab. 2015;26(7):S341-8.10.1016/j.tem.2015.02.007717165225801473
- 27. Selvaraj V, Stocco DM, Tu LN. Minireview: Translocator Protein (TSPO) and Steroidogenesis: A Reappraisal. Mol. Cell. Endocrinol. 2015; 29(4):S490-501.10.1210/me.2015-1033439928025730708
- 28. Papadopoulos V, Lecanu L, Brown RC, Han Z, Yao ZX. Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders. Neuroscience. 2006; 138(3):S749-56.10.1016/j.neuroscience.2005.05.06316338086
- 29. Reddy DS. Neurosteroids: endogenous role in the human brain and therapeutic potentials. Prog Brain Res. 2010;186:S113-37.10.1016/B978-0-444-53630-3.00008-7313902921094889
- 30. Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proc Natl Acad Sci U S A. 1986;83(23):S8962-66.10.1073/pnas.83.23.89623870543024157
- 31. Yasushi H, Suguru M. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids. Front Endocrinol. 2018;9:S183.10.3389/fendo.2018.00183592596229740398
- 32. Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E et al. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci USA. 2006;103(39):S14602-7.10.1073/pnas.0606544103
- 33. Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA. The Regulation of Steroid Action by Sulfation and Desulfation. Endocr Rev. 2015;36(5):S526-63.10.1210/er.2015-1036
- 34. Hobkirk R. Steroid sulfation. Trends Endocrinol. Metab. 1993; 4(2):S 69-74.10.1016/S1043-2760(05)80018-9
- 35. Do Rego JL, Seong JY, Burel D et al. Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Front Endocrinol (Lausanne). 2012; 3:S4.10.3389/fendo.2012.00004
- 36. Compagnone NA, Mellon SH. Neurosteroids: biosynthesis and function of these novel neuromodulators. Front. Neuroendocrinol. 2000;21(1):S1-56.10.1006/frne.1999.0188
- 37. Rupprecht R, Reul JM, Trapp T et al. Progesterone receptor-mediated effects of neuroactive steroids. Neuron. 1993;11(3):S523-30.10.1016/0896-6273(93)90156-L
- 38. Joëls M. Steroid Hormones and Excitability in the Mammalian Brain. Front. Neuroendocrinol. 1997;18(1):2-48.
- 39. Reddy DS, Apanites LA. Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice. Brain Res. 2005;1033(1):S96-101.10.1016/j.brainres.2004.11.02615680344
- 40. Reddy DS, Castaneda DC, O’Malley BW, Rogawski MA. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice. J Pharmacol Exp Ther. 2004;310(1):S230-9.10.1124/jpet.104.06526814982969
- 41. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 1986;232(4753):S1004-7.10.1126/science.24227582422758
- 42. Lambert JJ, Belelli D, Hill-Venning C. et al. Neurosteroid modulation of native and recombinant GABA-A receptors. Cell Mol Neurobiol. 1996;16(2):S155-74.10.1007/BF020881748743967
- 43. Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol.1991;40(3):S333-6.
- 44. Sieghart W. Structure, pharmacology and function of GABAA receptor subtypes. Adv. Pharmacol. 2006;54:S231-63.10.1016/S1054-3589(06)54010-4
- 45. Porcu P, Barron AM, Frye CA, Walf AA, Yang SY, He XY. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research. J Neuroendocrinol. 2016;28(2):S1-19.10.1111/jne.12351
- 46. Nakamura Y, Darnieder LM, Deeb TZ et al. Regulation of GABAA Rs by Phosphorylation. Adv Pharmacol. 2015;72:S97-146.10.1016/bs.apha.2014.11.008
- 47. Majewska MD. Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance. Prog. Neurobiol. 1992;38(4):S379-94.10.1016/0301-0082(92)90025-A
- 48. Reddy DS. Pharmacology of endogenous neuroactive steroids, Crit Rev Neurobiol. 2003;15:S197-234.10.1615/CritRevNeurobiol.v15.i34.20
- 49. Morrow AL. Recent developments in the significance and therapeutic relevance of neuroactive steroids - Introduction to the special issue. Pharmacol Ther. 2007;116(1):S1-6.10.1016/j.pharmthera.2007.04.003204781617531324
- 50. Hénin J, Salari R, Murlidaran S et al. A predicted binding site for cholesterol on the GABAA receptor. Biophys. J. 2014;106(9):S1938-49.10.1016/j.bpj.2014.03.024401728524806926
- 51. Paul SM, Doherty JJ, Robichaud AJ et al. The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors. J Neurosci. 2013; 33(44):S17290–300.10.1523/JNEUROSCI.2619-13.2013381250224174662
- 52. Li F, Tsien JZ. Memory and the NMDA receptors. N Engl J Med. 2009; 361(3):S302-3.10.1056/NEJMcibr0902052370375819605837
- 53. Schumacher M, Robel P. Baulieu EE. Development and regeneration of the nervous system: a role for neurosteroids. Dev Neurosci. 1996;18(1-2):S 6-21.10.1159/000315793
- 54. Lambert JJ, Cooper MA, Simmons RDJ, Weir CJ, Belelli D. Neurosteroids: Endogenous allosteric modulators of GABAA receptors. Psychoneuroendocrinology. 2009;34(1):S48-58.10.1016/j.psyneuen.2009.08.009
- 55. Mayo W, Dellu F, Robel P, Cherkaoui J, Le Moal M, Baulieu EE et al. Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat. Brain Res. 1993;607(1-2):S324-8.10.1016/0006-8993(93)91524-V
- 56. Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ et al. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. U.S.A. 2010;107(24):S11145.10.1073/pnas.1006236107
- 57. Bengtsson SK, Johansson M, Bäckström T, Wang M. Chronic allopregnanolone treatment accelerates Alzheimer’s disease development in βPP(Swe)PSEN1(ΔE9) mice. J Alzheimers Dis. 2012;31(1):S71-84.10.3233/JAD-2012-120268
- 58. Bengtsson SK, Johansson M, Bäckström T, Nitsch RM, Wang M. Brief but Chronic Increase in Allopregnanolone Cause Accelerated AD Pathology Differently in Two Mouse Models. Curr Alzheimer Res. 2013;10(1):S38-47.10.2174/156720513804871363
- 59. Ladurelle N, Eychenne B, Denton D, Blair-West J, Schumacher M, Robel P et al. Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse. Brain Res. 2000;858(2):S371-9.10.1016/S0006-8993(00)01953-3
- 60. Darnaudéry M, Koehl M, Piazza PV, Le Moal M, Mayo W. Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition. Brain Res. 2000;852(1):S173-9.10.1016/S0006-8993(99)01964-2
- 61. Hillen T, Lun A, Reischies FM, Borchelt M, Steinhagen-Thiessen E, Schaub RT. DHEA-S plasma levels and incidence of Alzheimer’s disease. Biol. Psychiatry. 2000;47(2):S161-3.10.1016/S0006-3223(99)00217-6
- 62. Maurice T, Su TP. Privat A. Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism. Neuroscience. 1998;83(2):S413-28.10.1016/S0306-4522(97)00405-3
- 63. Riedel G, Davies SN. Cannabinoid Function in Learning, Memory and Plasticity. Cannabinoids. Handb Exp Pharmacol. 2005;168:S445-77.10.1007/3-540-26573-2_1516596784
- 64. Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD et al. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cereb Cortex. 2018;28(7):S2253-66.10.1093/cercor/bhx126
- 65. Gaspar PA, Bustamante ML, Silva H, Aboitiz F. Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications. J Neurochem. 2009;111(4):S891-900.10.1111/j.1471-4159.2009.06325.x
- 66. Labrie V, Roder JC. The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia. Neurosci Biobehav Rev. 2010;34(3):S351-72.10.1016/j.neubiorev.2009.08.002
- 67. Marx CE, Keefe RS, Buchanan RW et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology. 2009;34(8):S1885-903.10.1038/npp.2009.26
- 68. Riordan AJ, Schaler AW, Fried J, Paine TA, Thornton JE. Estradiol and luteinizing hormone regulate recognition memory following subchronic phencyclidine: Evidence for hippocampal GABA action. Psychoneuroendocrinology. 2018; 91:S86-9410.1016/j.psyneuen.2018.02.024
- 69. Li PK, Rhodes ME, Burke AM et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine. Life Sci. 1997;60(3):S 45-51.10.1016/S0024-3205(96)00621-2
- 70. Wang C, Marx CE, Morrow AL, Wilson WA, Moore SD. Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. Neurosci Lett. 2007;415(2):S118-23.10.1016/j.neulet.2007.01.004189263117275189
- 71. Ströhle A, Romeo E, Michele F et al. Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results. Arch Gen Psychiatry. 2003;60(2):S161-8.10.1001/archpsyc.60.2.16112578433