References
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68(6),394–424.
- Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A et al. Colorectal cancer statistics, 2017. CA Cancer J. Clin. 2017;67(3),177–193.
- Makovec T. Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy. Radiol Oncol. 2019;53(2):148–158.
- Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014;740:364–378.
- Markman M. Toxicities of the platinum antineoplastic agents. Expert Opin Drug Saf. 2003;2(6):597–607.
- Trondl R, Heffeter P, Kowol CR, Jakupec MA, Berger W, Keppler BK. NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application. Chem Sci. 2014;5,2925–2932.
- Wang J, Zhao Z, Zhou S, Zhang X, Bo H. The antitumor effect and toxicity of a ruthenium(II) complex in vivo. Inorg Chem Commun.2018;87:49–52.
- Kanaoujiya R, Singh M, Singh J and Srivastava S. Ruthenium based anticancer compounds and their importance. J Sci Res. 2020;64(1):264–268.
- Carnizello AP, Alves JM, Pereira DE, Campos JCL, Barbosa MIF, Batista AA, Tavares DC. Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct-[RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine], by in vitro and in vivo assays. J Appl Toxicol. 2019;39(4):630–638.
- Deavall DG, Martin EA, Horner JM, Roberts R. Drug-induced oxidative stress and toxicity. J Toxicol. 2012;2012:645460.
- McWhirter D, Kitteringham N, Jones RP, Malik H, Park K, Palmer D. Chemotherapy induced hepatotoxicity in metastatic colorectal cancer: a review of mechanisms and outcomes. Crit Rev Oncol Hematol. 2013;88(2):404–415.
- Conklin KA. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther. 2004;3(4):294–230.
- Savic M, Arsenijevic A, Milovanovic J, Stojanovic B, Stankovic V, Rilak Simovic A, Lazic D, Arsenijevic N, Milovanovic M. Antitumor Activity of Ruthenium(II) Terpyridine Complexes towards Colon Cancer Cells In Vitro and In Vivo. Molecules. 2020;25(20):4699.
- Rilak A, Bratsos I, Zangrando E, Kljun J, Turel I, Bugarčić ŽD, Alessio E. New water-soluble ruthenium(II) terpyridine complexes for anticancer activity: synthesis, characterization, activation kinetics, and interaction with guanine derivatives. Inorg Chem. 2014;53 (12):6113–6126.
- Gou HF, Huang J, Shi HS, Chen XC, Wang YS. Chemoimmunotherapy with oxaliplatin and interleukin-7 inhibits colon cancer metastasis in mice. PLoS One 2014;21;9(1).
- Tan S, Peng X, Peng W, Zhao Y, Wei Y. Enhancement of oxaliplatin-induced cell apoptosis and tumor suppression by 3-methyladenine in colon cancer. Oncol Lett. 2015;9(5):2056–2062.
- Terracina KP, Aoyagi T, Huang WC, Nagahashi M, Yamada A, Aoki K, Takabe K. Development of a metastatic murine colon cancer model. J Surg Res. 2015;199(1):106–114.
- Stojic IM, Zivkovic VI, Srejovic IM, et al. Cisplatin and cisplatin analogues perfusion through isolated rat heart: the effects of acute application on oxidative stress biomarkers. Mol Cell Biochem. 2018;439(1-2):19–33.
- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358.
- Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882–8.
- Aebi H. Catalase in vitro. Methods Enzymol. 1984;105(25),121–126.
- Beutler E. Superoxide dismutase. In: Beutler E (ed) Red cell metabolism a manual of biochemical methods. Grune & Stratton, Philadelphia, 1984;83–85.
- Golbaghi G and Castonguay A. Rationally Designed Ruthenium Complexes for Breast Cancer Therapy. Molecules. 2020;25(2)265.
- Alves de Souza CE, Alves de Souza HM, Stipp MC, et al. Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med. 2017;110:228–239.
- Zeng L, Gupta P, Chen Y, et al. The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials. Chem Soc Rev. 2017;46(19):5771–5804.
- Morris-Stiff G, Tan YM, Vauthey JN. Hepatic complications following preoperative chemotherapy with oxaliplatin or irinotecan for hepatic colorectal metastases. Eur J Surg Oncol. 2008;34(6):609–614.
- Bano N, Ikram R. Histopathological and biochemical assessment of kidney damage in albino wistar rats treated with cytotoxic platinum compounds in combination with 5-FU. Pak J Pharm Sci. 2017;30(5):1595–601.
- Elsayed SA, Harrypersad S, Sahyon HA, El-Magd MA, Walsby CJ. Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity. Molecules. 2020;25(18):4284.
- Castro JP, Grune T, Speckmann B. The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction. Biol. Chem. 2016;397:709–724.
- Weinberg F, Ramnath N, Nagrath D. Reactive Oxygen Species in the Tumor Microenvironment: An Overview. Cancers (Basel). 2019;11(8):1191.
- Harris AL. Hypoxia? A key regulatory factor in tumour growth. Nat Rev Cancer. 2002;2:38–47.
- Forster JC, Harriss-Phillips WM, Douglass MJ, Bezak E. A review of the development of tumor vasculature and its effects on the tumor microenvironment. Hypoxia (Auckl). 2017;5:21–32.
- Mello-Andrade F, Cardoso CG, Silva CRE, Chen-Chen L, Melo-Reis PR, Lima AP, Oliveira R, Ferraz IBM, Grisolia CK, Almeida MAP, Batista AA, Silveira-Lacerda EP. Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos. Biomed Pharmacother. 2018;107:1082–1092.
- Kostova I. Ruthenium complexes as anticancer agents. Curr Med Chem. 2006;13(9):1085–1107.
- Teixeira TM, Arraes IG, Abreu DC, Oliveira KM, Correa RS, Batista AA, Braunbeck T, de Paula Silveira Lacerda E. Ruthenium complexes show promise when submitted to toxicological safety tests using alternative methodologies. Eur J Med Chem. 2021;216:113262.
- Montjean D, Ménézo Y, Benkhalifa M, Cohen M, Belloc S, Cohen-Bacrie P, and De Mouzon J. Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen species. Zygote. 2010;18:265–268.
- Ciftci O, Ozdemir I, Cakir O, Demir S. The determination of oxidative damage in heart tissue of rats caused by ruthenium(II) and gold(I) N-heterocyclic carbene complexes. Toxicology and Industrial Health. 2011;27(8):735–741.
- Mihajlovic K, Milosavljevic I, Jeremic J, Savic M, Sretenovic J, Srejovic I, Zivkovic V, Jovicic N, Paunovic M, Bolevich S, Jakovljevic V, Novokmet S. Redox and apoptotic potential of novel ruthenium complexes in rat blood and heart. Can J Physiol Pharmacol. 2021;99(2):207–217.
- Eöry ML, Zanuzzi CN, Fuentealba NA, Sguazza GH, Gimeno EJ, Galosi CM, Barbeito CG. Effects of different anesthetics in the murine model of EHV-1 infection. Vet Pathol. 2013;50(5):849–856.
- Mohanraj M, Ayyannan G, Raja G, Jayabalakrishnan C. Synthesis, spectral characterization, DNA interaction, radical scavenging and cytotoxicity studies of ruthenium(II) hydrazone complexes. J Photochem Photobiol B. 2016;158,164–173.