Have a personal or library account? Click to login
Memantine Therapy as an Augmentation in Treatment-Resistant Depression: A Case Report Cover

Memantine Therapy as an Augmentation in Treatment-Resistant Depression: A Case Report

Open Access
|Dec 2025

References

  1. Souery, D., Papakostas, G. I., & Trivedi, M. H. (2006). Treatment-resistant depression. The Journal of clinical psychiatry, 67 Suppl 6, 16–22.
  2. Berlim, M. T., & Turecki, G. (2007). Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 52(1), 46–54. https://doi.org/10.1177/070674370705200108
  3. Serafini, G., Adavastro, G., Canepa, G., Capobianco, L., Conigliaro, C., Pittaluga, F., Murri, M. B., Valchera, A., De Berardis, D., Pompili, M., Lindqvist, D., Brundin, L., & Amore, M. (2017). Abnormalities in Kynurenine Pathway Metabolism in Treatment-Resistant Depression and Suicidality: A Systematic Review. CNS & neurological disorders drug targets, 16(4), 440–453. https://doi.org/10.2174/1871527316666170413110605
  4. Czarnecka, K., Chuchmacz, J., Wójtowicz, P., & Szymański, P. (2021). Memantine in neurological disorders - schizophrenia and depression. Journal of molecular medicine (Berlin, Germany), 99(3), 327–334. https://doi.org/10.1007/s00109-020-01982-z
  5. Réus, G. Z., de Moura, A. B., Borba, L. A., Abelaira, H. M., & Quevedo, J. (2019). Strategies for Treatment-Resistant Depression: Lessons Learned from Animal Models. Molecular neuropsychiatry, 5(4), 178–189. https://doi.org/10.1159/000500324
  6. Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000). Antidepressant effects of ketamine in depressed patients. Biological psychiatry, 47(4), 351–354. https://doi.org/10.1016/s0006-3223(99)00230-9
  7. Garcia, L. S., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., & Quevedo, J. (2008). Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry, 32(1), 140–144. https://doi.org/10.1016/j.pnpbp.2007.07.027..
  8. Liebrenz, M., Borgeat, A., Leisinger, R., & Stohler, R. (2007). Intravenous ketamine therapy in a patient with treatment-resistant major depression. Swiss medical weekly, 137(15-16), 234–236.
  9. Strzelecki, D., Tabaszewska, A., Barszcz, Z., Józefowicz, O., Kropiwnicki, P., & Rabe-Jabłońska, J. (2013). A 10-week memantine treatment in bipolar depression: a case report. Focus on depressive symptomatology, cognitive parameters and quality of life. Psychiatry investigation, 10(4), 421–424. https://doi.org/10.4306/pi.2013.10.4.421
  10. Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000). Antidepressant effects of ketamine in depressed patients. Biological psychiatry, 47(4), 351–354. https://doi.org/10.1016/s0006-3223(99)00230-9
  11. Réus, G. Z., Stringari, R. B., Kirsch, T. R., Fries, G. R., Kapczinski, F., Roesler, R., & Quevedo, J. (2010). Neurochemical and behavioral effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?. Brain research bulletin, 81(6), 585–589. https://doi.org/10.1016/j.brainresbull.2009.11.013
  12. Onogi, H., Ishigaki, S., Nakagawasai, O., Arai-Kato, Y., Arai, Y., Watanabe, H., Miyamoto, A., Tan-no, K., & Tadano, T. (2009). Influence of memantine on brain monoaminergic neurotransmission parameters in mice: neurochemical and behavioral study. Biological & pharmaceutical bulletin, 32(5), 850–855. https://doi.org/10.1248/bpb.32.850
  13. Ferguson, J. M., & Shingleton, R. N. (2007). An open-label, flexible-dose study of memantine in major depressive disorder. Clinical neuropharmacology, 30(3), 136–144. https://doi.org/10.1097/WNF.0b013e3180314ae7
  14. Zarate, C. A., Jr, Singh, J. B., Quiroz, J. A., De Jesus, G., Denicoff, K. K., Luckenbaugh, D. A., Manji, H. K., & Charney, D. S. (2006). A double-blind, placebo-controlled study of memantine in the treatment of major depression. The American journal of psychiatry, 163(1), 153–155. https://doi.org/10.1176/appi.ajp.163.1.153
DOI: https://doi.org/10.2478/sjecr-2022-0054 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Page range: 211 - 216
Submitted on: Aug 30, 2021
|
Accepted on: Mar 12, 2022
|
Published on: Dec 31, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Milena Stojkovic, Vladimir Janjic, Nemanja Muric, Nenad Zornic, Vladimir Jakovljevic, Vladimir Zivkovic, Branimir Radmanovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.