Table 1
Characteristics of the study population included in the study, Morelos, Mexico.
| Characteristics | n = 745 | % | Percentiles | |
|---|---|---|---|---|
| P25 | P75 | |||
| Mother’s Age (years) | ||||
| Mean ± SD | 26.3 ± 4.7 | 22.6 | 29.9 | |
| Education (years) | ||||
| ≤6 | 13 | 1.74 | ||
| 7 to 12 | 297 | 39.81 | ||
| 13 to 15 | 148 | 19.84 | ||
| >15 | 288 | 38.61 | ||
| Parity > 1 | 474 | 63.54 | ||
| Height (cm) | ||||
| Mean ± SD | 155.3 ± 5.7 | 152 | 159 | |
| Pre-gestational Weight | ||||
| Mean ± SD | 61 ± 10.9 | 53.5 | 67.3 | |
| Body Mass Index* | ||||
| Mean ± SD | 25.2 ± 4 | 22.3 | 27.7 | |
| Vitamin Supplements | ||||
| Yes | 722 | 96.78 | ||
| Smoking** | ||||
| Non-smoker | 733 | 98.26 | ||
| Passive | 304 | 40.75 | ||
| Active | 13 | 1.74 | ||
| Treatment Group*** | ||||
| Supplement | 365 | 48.93 | ||
| Placebo | 381 | 51.07 | ||
| Newborns | ||||
| Birth Weight (g) | ||||
| Mean ± SD | 3216.9 ± 439 | 2970 | 3500 | |
| Sex (%) | ||||
| Male | 399 | 53.49 | ||
| Female | 346 | 46.51 | ||
| Gestational age (weeks) | ||||
| Mean ± SD | 39.1 ± 1.7 | 38.1 | 40.1 | |
[i] *: Pre-gestational.
**: During pregnancy.
***: Omega-3 fatty acid supplements during pregnancy.
Table 2
Estimated* Nitrogen Oxides Concentrations during study period, Morelos, Mexico.
| Pollutants | n | Mean ± SD | p25 | Median | p75 |
|---|---|---|---|---|---|
| NO ppb | 745 | 2.7 ± 2.04 | 1.2 | 2.01 | 4.1 |
| NO2 ppb | 735 | 19.9 ± 23.8 | 10.7 | 16.5 | 20.8 |
| NOx ppb | 731 | 19.6 ± 5.6 | 16.2 | 21.04 | 23.5 |
| Wind speed m/sec | 745 | 2.51 ± .10 | 2.4 | 2.5 | 2.6 |
| Temperature °C | 745 | 20.3 ± 2.64 | 19 | 20.5 | 22.4 |
[i] * By predictive land use regression models.
Table 3
Association (coefficient per interquartile range increase) between prenatal exposure to nitrogen oxides and birth weight of newborns from Morelos, Mexico.
| Pollutants | Birth weight* (g) | ||
|---|---|---|---|
| β** | CI 95% | p-value | |
| NO (n = 745) | –42.46 | –82.73; –2.18 | 0.04 |
| NO2 (n = 734) | 8.06 | –4.07; 20.20 | 0.19 |
| NOx (n = 730) | –39.61 | –77.00; –2.21 | 0.04 |
[i] *: Models adjusted for mother’s age and height, gestational age, sex, and passive smoking.
**: Calculated coefficient for the interquartile range: NO = 3.29ppb, NO2 = 10.16 ppb and NOx = 6.95 ppb.

Figure 1
Spatial distribution of estimated nitrogen oxides concentrations in the study zone.
