
Irregularities in the IARC Working Group Evaluation of Ramazzini Institute Aspartame Studies
References
- International Agency for Research on Cancer (IARC).
Aspartame . IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Vol 134. Lyon, France: IARC; 2024:1–533. - Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriola M. Life‑span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect. 2007;115(9):1293–1297. doi:10.1289/ehp.10271.
- Belpoggi F, Soffritti M, Padovani M, Degli Esposti D, Lauriola M, Minardi F. Results of long‑term carcinogenicity bioassay on Sprague‑Dawley rats exposed to aspartame administered in feed. Ann NY Acad Sci. 2006;1076:559–577. doi:10.1196/annals.1371.080.
- Soffritti M, Belpoggi F, Manservigi M, et al. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice. Am J Ind Med. 2010;53:1197–1206. doi:10.1002/ajim.20896.
- Chiozzotto D, Soffritti M, Falcioni L, et al. Results of lifespan carcinogenicity bioassay on Sprague‑Dawley rats exposed to aspartame since foetal life. Eur J Oncol. 2011;16(2):81–97.
- Tibaldi E, Gnudi F, Panzacchi S, et al. Identification of aspartame‑induced haematopoietic and lymphoid tumours in rats after lifetime treatment. Acta Histochem. 2020;122(5):151548. doi:10.1016/j.acthis.2020.151548.
- Gnudi F, Panzacchi S, Tibaldi E, et al. Hemolymphoreticular neiplasias from the Ramazzini Institute long‑term mice and rat studies on aspartame. Ann Glob Health. 2023;89(1):43. doi:10.5334/aogh.4163. PMID:37362827.
- International Agency for Research on Cancer (IARC).
Benzene . IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Vol 120. Lyon, France: IARC; 2018:1–309. - Stayner LT, Carreon‑Valencia T, Demers P, et al. Carcinogenicity of talc and acrylonitrile. Lancet Oncol. 2024;25(8):962–963. doi:10.1016/S1470-2045(24)00384-X.
DOI: https://doi.org/10.5334/aogh.4771 | Journal eISSN: 2214-9996
Language: English
Submitted on: Apr 15, 2025
Accepted on: Apr 22, 2025
Published on: Jun 6, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
© 2025 Philip J Landrigan, Kurt Straif, Linda S Birnbaum, Melissa McDiarmid, Melissa J Perry, Francesco Forastiere, Pietro Comba, John R Bucher, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.