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Figures & Tables

Figure 1

ACS-Gt Registry Methodology.

Table 1

Demographic and clinical characteristics.

STEMINSTEMI/UATOTALP
N = 88N = 21N = 109
x̄ ± SDx̄ ± SDx̄ ± SD
Age ∼ years60.9 ± 11.264.9 ± 12.661.6 ± 11.60.15
Weight ∼ kg72.7 ± 10.470.6 ± 12.370.8 ± 140.43
N (%)N (%)N (%)
Gender0.25
    Male69 (78)14 (66.7)83 (68)
Housing0.98
    Rural38 (43.2)9 (42.9)47 (43.1)
Educational level0.43
    Illiterate11 (12.6)4 (19)15 (13.9)
    Elementary school37 (42.5)12 (57.1)49 (45.4)
    High school25 (28.7)2 (9.5)27 (25)
    Technical degree10 (11.5)2 (9.5)12 (11.1)
    Bachelor’s degree or higher4 (4.6)1 (4.8)5 (4.6)
Occupation0.41
    Informal commerce19 (21.8)8 (38.1)27 (25)
    Housewife16 (18.4)5 (23.8)21 (19.4)
    Unemployed18 (20.7)1 (4.8)19 (17.6)
    Technical14 (16.1)3 (14.3)17 (15.7)
    Professional8 (9.2)2 (9.5)10 (9.3)
    Agriculture6 (6.9)2 (9.5)8 (7.4)
    Formal commerce6 (6.9)0.06 (5.6)
Established hospital protocol for acute coronary syndrome11 (12.5)1 (4.8)12 (11)0.31
Medical history
    Systemic hypertension43 (48.9)11 (52.4)54 (49.5)0.77
    Diabetes mellitus40 (45.5)10 (47.6)50 (45.9)0.85
    Smoking24 (27.3)3 (14.3)27 (24.8)0.22
    Dyslipidaemia19 (21.8)2 (9.5)21 (19.4)0.2
    Acute coronary syndrome11 (12.6)4 (19)15 (13.9)0.44
    Other20 (22)6 (21)26 (23)0.62
Medication history
    ACEI/ARB34 (39.1)9 (42.9)43 (39.8)0.75
    Acetylsalicylic acid7 (8)5 (23.8)12 (11.1)0.03
    Insulin9 (10.3)3 (14.3)12 (11.1)0.6
    CCB5 (5.7)4 (19)9 (8.3)0.04
    P2Y12 inhibitor5 (5.7)1 (4.8)6 (5.6)0.86
    β-blocker5 (5.7)1 (4.8)6 (5.6)0.86
    Statins3 (3.4)2 (9.5)5 (4.6)0.24
    Nitrites1 (1.1)1 (4.8)2 (1.9)0.27

[i] STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, ACEI: Angiotensin-converting enzyme inhibitors, ARB: Angiotensin II receptor blocker, CCB: Calcium channel blocker.

Table 2

STEMI and NSTEMI individual characteristics.

STEMI CHARACTERISTICSSTEMI
N = 88
N (%)
Electrocardiographic location
    Anterior45 (51.1)
    Inferior38 (43.2)
    Lateral5 (5.7)
Reperfusion52 (59.1)
Type of reperfusion
    Fibrinolysis52 (100)
Fibrinolytic
    Alteplase34 (65.4)
    Streptokinase17 (32.7)
    Tenecteplase1 (1.9) *
Reason PCI was not performed
    No cardiac catherization laboratory65 (73.9)
    Time from symptom onset > 12 hours13 (14.8)
    Not considered by physician7 (8)
    Patient refused treatment2 (2.3)
    Hospital transfer not accepted1 (1.1)
Reason fibrinolysis was not performed
    Time from symptom onset > 12 hours18 (50)
    Not considered by physician13 (36.1)
    Lack of medical supplies3 (8.3)
    Contraindicated1 (2.8)
    Patient refused treatment1 (2.8)
Angiography/PCI use in non-reperfused myocardial infarction7 (19.4)
Ischaemia or viability evaluated prior to angiography/PCI in non-reperfused myocardial infarction4 (57)
Treatment centre where fibrinolysis was performed
    Public hospital (MSPAS)44 (84.6)
    Private hospital7 (13.5)
    Guatemalan social security institute (IGSS)1 (1.9)
Successful fibrinolysis34 (65.4)
Angiography/PCI after successful fibrinolysis17 (50)
Within first 24 hours0.0
After 24 hours17 (100)
Cause of failed fibrinolysis
    Both6 (50)
    Persistent ischaemia5 (41.7)
    Failure of ST segment descent1 (8.3)
Rescue angioplasty1 (14.3) *
NSTEMI/UA CHARACTERISTICSNSTEMI/UA
N = 21
N (%)
Angiography/PCI performed5 (23.8)
    Diagnostic4 (80)
    PCI1 (20)
X̄± SD
    Days until angiography/PCI was performed6.4 ± 2.8
Electrocardiographic findings at admission
    T-wave inversion5 (29.4)
    ST-segment depression5 (29.4)
    No alterations4 (23.5)
    ST-depression in more than 6 leads and ST-elevation in aVR2 (11.8)
    Left Bundle Branch Block1 (5.9)
Crusade35.8 ± 20.8

[i] * Performed at a private hospital (after the procedure patient was transferred back for treatment at public hospital).

STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, PCI: percutaneous coronary intervention, MSPAS: “Ministerio de Salud Pública y Asistencia Social” (ministry of public health and social assistance), IGSS: “Instituto Guatemalteco de Seguridad social” (Guatemalan social security institute), UA: unstable angina.

Table 3

Clinical Presentation.

STEMINSTEMI/UATOTALP
N = 88N = 21N = 109
x̄ ± SDx̄ ± SDx̄ ± SD
Heart rate ∼ Bpm80.3 ± 24.991.4 ± 31.782.4 ± 26.50.08
GRACE129 ± 32109 ± 32125 ± 32.70.01
MEDIAN (25–75)MEDIAN (25–75)MEDIAN (25–75)
Systolic blood pressure ∼ mmHg115 (91.2–134.7)130 (110–140)120 (100–139)0.06
Oxygen saturation ∼ %95 (91.7–97)92 (86–96)94 (90.2–97)0.07
Diastolic blood pressure ∼ mmHg70 (60–84.5)80 (70–86)70 (60–84)0.22
Temperature ∼ °C37 (36.5–37)37 (36.7–37)37 (36.5–37)0.36
Respiratory rate ∼ Rpm18 (16–22)20 (17–24)19 (16–22)0.23
N (%)N (%)N (%)
Typical angina76 (86.4)16 (76.2)92 (84.4)0.24
Dyspnoea18 (20.5)9 (42.9)27 (24.8)0.03
Atypical angina8 (9.1)1 (4.8)9 (8.3)0.51
Syncope8 (9.1)1 (4.8)9 (8.3)0.51
Cardiac arrest1 (1.1)0.01 (0.9)0.62
Electrocardiographic findings at admission
    Sinus rhythm66 (75)19 (90.5)85 (78)0.12
    Third-degree AV block14 (15.9)0.014 (12.8)0.05
    Ventricular extrasystoles4 (4.5)1 (4.8)5 (4.6)0.96
    Second-degree AV block4 (4.5)0.04 (3.7)0.32
    Other2 (2.3)1 (4.8)3 (2.8)0.53
    Pacemaker rhythm0.02 (9.5)2 (1.8)<0.01
    Atrial fibrillation1 (1.1)0.01 (0.9)0.62
    First-degree AV block1 (1.1)0.01 (0.9)0.62
Killip-Kimball0.04
    I43 (48.9)13 (61.9)56 (51.4)
    II27 (30.7)4 (19)31 (28.4)
    III5 (5.7)4 (19)9 (8.3)
    IV13 (14.8)0.013 (11.9)
TIMI<0.01
    00.02 (9.5)2 (1.8)
    13 (3.4)2 (9.5)5 (4.6)
    28 (9.1)6 (28.6)14 (12.8)
    311 (12.5)8 (38)19 (17.4)
    49 (10)2 (9.5)11 (10)
    512 (13.6)0.012 (11)
    68 (9.1)1 (4.8)9 (8.3)
    ≥737 (42)0.037 (34)

[i] STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, UA: unstable angina, Bpm: beats per minute, GRACE: Grace Risk Score, Rpm: respirations per minute, mmHg: millimetres of mercury, °C: degrees Celsius, AV: atrioventricular, Killip-Kimball: prognostic score in acute coronary syndrome evaluating the risk of death during the first 30 days, TIMI: score that assesses mortality, reinfarction or recurrent ischaemia during the first 14 days.

Table 4

Process and delay.

STEMINSTEMI/UATOTALP
N = 88N = 21N = 109
x̄ ± SDx̄ ± SDx̄ ± SD
Prehospital delay
Time between ambulance call and arrival ∼ minutes*18.4 ± 14.630 ± 23.720.7 ± 16.80.17
MEDIAN (25–75)MEDIAN (25–75)MEDIAN (25–75)
Transfer time to FMC ∼ minutes22.5 (20–38.7)30 (12.5–60)25 (17.5–42.5)0.56
FMC ∼ minutes300 (126.2–842.2)185 (75–1035)180 (74–465)0.37
Transfer time from FMC to final treatment centre ∼minutes30 (20–60)120 (10–180)80 (30–141)0.46
N (%)N (%)N (%)P
Ambulance provided by0.96
Public hospital (MSPAS)11 (37.9)1 (33.3)12 (37.5)
Patient expense8 (27.6)1 (33.3)9 (28.1)
Social security institute (IGSS)8 (27.6)1 (33.3)9 (28.1)
Patient transport2 (6.9)0.02 (6.3)
Transfer destination
Public hospital (MSPAS)24 (82.8)3 (100)27 (84.4)
Private hospital**4 (13.8)0.04 (12.5)
Social security institute (IGSS)1 (3.4)0.01 (3.1)
Reason for second transfer<0.01
Elective PCI8 (27.6)1 (33.3)9 (28.1)
Family request3 (10.3)0.03 (9.4)
Intensive care2 (6.9)0.02 (6.3)
Lack of physical space0.01 (33.3)1 (3.1)
Diagnostic approach0.01 (33.3)1 (3.1)
Fibrinolysis11 (37.9)
Pharmaco-invasive strategy (after successful fibrinolysis)3 (10.3)
Rescue PCI2 (6.9)
Transfer characteristics
Performed by paramedic14 (56)2 (66.7)16 (57.1)0.9
Ambulance oxygen tank15 (65.2)1 (33.3)16 (61.5)0.34
Ambulance heart monitor8 (34.8)0.08 (30.8)0.34
Ambulance defibrillator5 (21.7)0.05 (19.2)0.53

[i] * Only applies if the patient was transferred by ambulance.

** Only applies to patients who were evaluated or treated at a private hospital and later referred to a public hospital. Patients who only received treatment at a private hospital were not included.

STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, UA: unstable angina, FMC: first medical contact, PCI: percutaneous coronary intervention, MSPAS: “Ministerio de Salud Pública y Asistencia Social” (ministry of public health and social assistance), IGSS: “Instituto Guatemalteco de Seguridad social” (Guatemalan social security institute).

Table 5

STEMI–delay in definitive treatment: ACS-Gt registry vs. ESC guidelines.

ACS-GTESC-STEMIDIFFERENCEP
MEDIAN (25–75)
Time between ECG and STEMI diagnosis ∼ minutes10 (5-20)<100.00.44
Door to needle ∼ minutes52.5 (27.7-71)<10+ 42<0.01
Door-in to door-out ∼ minutes120 (35-285)<30+ 90<0.01
Total ischaemic time ∼ minutes500 (388-720)<120+ 380<0.01
X̄ ± SD
Total ischaemic time (patients presenting <12 h) ∼ minutes439.5 ± 139.6<120+ 319<0.01
Time in which Angiography/PCI was performed after successful fibrinolysis ∼ hours*205.1 ± 102.92-24+ 181<0.01

[i] * Pharmaco-invasive strategy refers to angiography or PCI in a period of 2-24 hours; in the present study, no patient met this criterion. STEMI: ST-elevation myocardial infarction, ACS-Gt: Acute coronary syndrome-Guatemala, ESC: European society of cardiology, ECG: electrocardiogram, PCI: percutaneous coronary intervention.

Table 6

Structure in the attention of the acute coronary syndrome.

STEMINSTEMI/UATOTALP
N = 88N = 21N = 109
N (%)N (%)N (%)
Physician responsible0.42
    Internal medicine/emergency medicine resident61 (69.3)14 (66.7)75 (68.8)
    Internist13 (14.8)6 (28.6)19 (17.4)
    Cardiologist6 (6.8)1 (4.8)7 (6.4)
    General physician6 (6.8)0.06 (5.5)
    Other2 (2.3)0.02 (1.8)
Availability
    Fully working ambulance87 (100)21 (100)108 (100)
    Electrocardiogram87 (98.9)21 (100)108 (99.1)0.42
    Hospital beds87 (98.9)21 (100)108 (99.1)0.64
    Electrocardiogram paper86 (97.7)21 (100)107 (98.2)0.62
    Any cardiac enzyme80 (90.9)15 (71.4)95 (87.2)0.01
    Quantitative troponin74 (84.1)15 (71.4)89 (81.7)0.17
    CKMB73 (83)12 (57.1)85 (78)0.01
    Qualitative troponin10 (11.4)0.010 (9.2)0.1
    Any Fibrinolytic*87 (98.9)
    Streptokinase86 (98.9)
    Alteplase63 (72.4)
Discharged with appointment (UNICAR)8 (9.2)2 (10)10 (9.3)0.78
MEDIAN (25–75)MEDIAN (25–75)MEDIAN (25–75)
    Days until appointment20.5 (11.7–27)7.5 (7–8)17.7 (8–24)0.05

[i] *During the data collection period, only streptokinase and alteplase was available in the National Ministry of Public Health network. STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, UA: unstable angina, CKMB: creatin kinase-MB, UNICAR: “Unidad Nacional de Cirugía Cardiovascular” (Cardiovascular surgery unit of Guatemala).

Table 7

In-Hospital Medical Therapy.

MEDICATIONPRESCRIPTIONOPTIMAL MEDICAL THERAPY
STEMINSTEMI/UATOTALPSTEMINSTEMI/UATOTALP
N = 88N = 21N = 109N = 88N = 21N = 109
N (%)N (%)N (%)N (%)N (%)N (%)
Aspirin82 (95)21 (100)103 (97)0.3868 (83)14 (67)82 (80)0.9
Clopidogrel80 (94)21 (100)101 (95)0.2552 (66)6 (29)58 (58)<0.01
Enoxaparin18 (85)18 (85)83 (78)0.3531 (47)9 (50)40 (48)0.86
Unfractionated Heparin7 (82)0.07 (6.6)0.172 (28)
Fibrinolytic52 (59)41 (82)
Optimal In-Hospital Medical Therapy6 (6.8)3 (14.3)9 (8.3)0.26

[i] STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, UA: unstable angina.

Table 8

Discharge Medical Therapy.

MEDICATIONDISCHARGE PRESCRIPTION – LVEF ≤40%OPTIMAL MEDICAL THERAPY – LVEF ≤40%
STEMINSTEMI/UATOTALPSTEMINSTEMI/UATOTALP
N = 11N = 3N = 14N = 11N = 3N = 14
N (%)N (%)N (%)N (%)N (%)N (%)
P2Y12 inhibitor11 (100)2 (66)13 (92)0.0411 (100)2 (100)13 (100)
Statin11 (100)3 (100)14 (100)10 (90)2 (100)12 (92)0.65
Aspirin8 (72)2 (66)10 (71)0.838 (100)2 (100)10 (100)
β-blocker9 (81)2 (66)11 (78)0.576 (100)0.06 (85)<0.01
ARNI4 (36)2 (66)6 (42)0.344 (100)2 (100)6 (100)
ACE inhibitor/ARB6 (54)1 (33)7 (50)0.515 (83)0.05 (83)<0.01
Discharged Optimal Medical Therapy9 (81)2 (66)11 (78)0.57
MEDICATIONDISCHARGE PRESCRIPTION – LVEF ≥40%OPTIMAL MEDICAL THERAPY – LVEF ≥40%
STEMINSTEMI/UATOTALPSTEMINSTEMI/UATOTALP
N = 43N = 5N = 48N = 43N = 5N = 48
N (%)N (%)N (%)N (%)N (%)N (%)
P2Y12 inhibitors39 (95)5 (100)44 (95)0.6139 (100)5 (100)44 (100)
Aspirin39 (95)4 (80)43 (93)0.1939 (100)4 (100)43 (100)
Statin38 (92)5 (100)43 (93)0.5334 (82)5 (100)39 (84)0.31
Discharged Optimal Medical Therapy36 (83)4 (80)40 (83)0.83

[i] LVEF: left ventricular ejection fraction, STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, UA: unstable angina, OMT: optimal medical therapy.

Table 9

Outcome.

STEMINSTEMI/UATOTALP
N = 88N = 21N = 109
N (%)N (%)N (%)
In-hospital mortality16 (18.4)6 (28.6)22 (20.4)0.29
Cause0.76
    Cardiogenic shock9 (56.3)2 (33.3)11 (50)
    Reinfarction2 (12.5)1 (16.7)3 (13.6)
    Stroke1 (6.3)1 (16.7)2 (9.1)
    Ventricular Arrythmias1 (6.3)0.01 (4.5)
    Other non-specified3 (18.8)2 (33.3)5 (22.7)
In-hospital mortality and reperfusion status
    Non-reperfused9 (25.7)
    Reperfused7 (13.5)
30-day mortality0.38
    Lost in follow-up3 (4.6)1 (7.7)4 (5.1)
    Deceased1 (1.5)1 (7.7)2 (2.6)
In-hospital morbidity46 (52.9)8 (38.1)54 (50)0.22
Cause
    Non-cardiovascular35 (39.8)8 (38.1)43 (39.4)0.88
    Non-lethal ventricular arrythmia4 (4.5)1 (4.8)5 (4.6)0.96
    Heart Failure4 (4.5)0.04 (3.7)0.32
    Non-lethal stroke3 (3.4)0.03 (2.8)0.39
    Haemorrhagic complication3 (3.4)0.03 (2.8)0.39
    Non-lethal reinfarction3 (3.4)0.03 (2.8)0.39
    Supraventricular Arrythmias2 (2.3)0.02 (1.8)0.48
    Reverted cardiac arrest1 (1.1)0.01 (0.9)0.62
    GUSTO classification
        Severe1 (33.3)
        Mild2 (66.7)
    Cardiogenic shock16 (18.2)2 (9.5)18 (16.5)0.33
    Pharmacotherapy0.79
        Both13 (81.3)2 (100)15 (83.3)
        Vasopressor2 (12.5)0.02 (11.1)
        Inotropic1 (6.3)0.01 (5.6)
Echocardiogram previous to discharge56 (63.6)7 (33.3)63 (57.8)0.01
Performed by
Private clinic52 (89.7)7 (87.5)59 (89.4)
National Ministry of Public Health6 (10.3)1 (12.5)7 (10.6)
X̄ ± SDX̄ ± SDX̄ ± SD
LVEF ∼ %49.5 ± 9.342.1 ± 16.848.5 ± 10.60.06
median (25–75)median (25–75)median (25–75)
In-hospital length of staydays10 (6–14)7 (4.5–9)8 (4–14)0.45

[i] STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction, UA: unstable angina, LVEF: left ventricular ejection fraction.

Figure 2

In-hospital ACS mortality [27, 47, 48].

Figure 3

Mortality by type of ACS. STEMI: ST-elevation myocardial infarction, NSTEMI: non-ST elevation myocardial infarction [27, 28, 47, 49].

DOI: https://doi.org/10.5334/gh.1168 | Journal eISSN: 2211-8179
Language: English
Submitted on: Dec 16, 2021
Accepted on: Oct 5, 2022
Published on: Dec 1, 2022
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 José Antonio Cornejo-Guerra, Magda Isabel Ramos-Castro, Mariana Gil-Salazar, Sofia Leal-Wittkowsky, Juan Carlos Santis-Mejía, Elisa María Anleu-De León, Oscar Fernando Castro-Alvarado, Boris Rudy Alexander López-Quiñónez, Edgar Alexander Illescas-González, Paola Overall-Salazar, Luis Antonio Rodríguez-Cifuentes, Karla Yesenia Miranda-Sandoval, Juan Pablo Pineda, Kevin Oneal Flores-Andrade, Roberto Antonio Pérez-Reyes, Sofía Waleska Girón-Blas, Josué Fernando Samayoa-Ruano, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.