Figure 1
Patient trajectory in our cohort.
Table 1
Baseline characteristics of the patients.
| N = 81 | |
|---|---|
| Age (years), median (interquartile range) | 24 (22–28.5) |
| Multiparous, n (%) | 34 (42.0%) |
| Hypertension, n (%) | 4 (4.9%) |
| Smoking habits, n (%) | 2 (2.5%) |
| Congenital heart disease, n (%) | 9 (11.1%) |
| Rheumatic fever, n (%) | 60 (74.1%) |
| Previous cardiovascular medication, n (%) | 35 (43.2%) |
| Impaired left ventricular ejection fraction, n (%) | 10 (12.3%) |
| NYHA class III or IV, n (%) | 17 (21.0%) |
| Previous arrhythmic event, n (%) | 10 (12.3%) |
| Previous stroke, n (%) | 7 (8.6%) |
| Previous infectious endocarditis, n (%) | 5 (6.2%) |
| Anticoagulation, n (%) | 49 (60.5%) |
| Warfarin | 22 (27.2%) |
| Acenocoumarol | 27 (33.3%) |
[i] NYHA, New York Heart Association.
Table 2
Valvular heart disease characterization.
| N = 81 | |
|---|---|
| Cardiac valve involved, n (%) | |
| Mitral | 54 (66.7%) |
| Mitral and aortic | 12 (14.8%) |
| Mitral and tricuspid | 7 (8.6%) |
| Aortic | 5 (6.2%) |
| Pulmonary | 3 (3.7%) |
| Native valvular disease, n (%) | 15 (18.5%) |
| Mitral regurgitation | 5 (6.2%) |
| Aortic and mitral regurgitation | 4 (4.9%) |
| Mitral valve prolapse with regurgitation | 3 (3.7%) |
| Aortic regurgitation | 2 (2.5%) |
| Moderate mitral stenosis | 1 (3.3%) |
| Previous surgical or percutaneous correction before conception (without prosthesis), n (%) | 18 (22.2%) |
| Mitral stenosis/regurgitation | 13 (16.0%) |
| Pulmonary stenosis | 3 (3.7%) |
| Aortic stenosis | 2 (2.5%) |
| Valvular prosthesis, n (%) | 48 (59.3%) |
| Mechanical prosthesis | 38 (46.9%) |
| Mitral | 43 (53.1%) |
| Aortic | 8 (9.9%) |
Figure 2
Distribution of anticoagulant treatment according to the weeks of gestation in patients with MHV.
Table 3
Obstetric and fetal outcomes.
| N = 81 | |
|---|---|
| Maternal outcomes | |
| NYHA class worsening, n (%) | 35 (42.0%) |
| Need to initiate/intensify cardiac medication, n (%) | 8 (9.9%) |
| Acute pulmonary oedema, n (%) | 4 (4.9%) |
| Haemorrhagic complications, n (%) | 7 (8.6%) |
| Thrombotic complications, n (%) | 4 (4.9%) |
| All-cause mortality, n (%) | 1 (1.2%) |
| Fetal outcomes | |
| Live birth, n (%) | 56 (69.1%) |
| Miscarriages, n (%) | 19 (23.5%) |
| Stillbirth, n (%) | 6 (7.4%) |
| Fetal malformations, n (%) | 12 (14.8%) |
| Gestational age at delivery (weeks), mean ± SD | 35.4 ± 6.9 |
| Weight, g | 3026.4 ± 471.4 |
| Apgar index > 7 at 5th minute, n (%) | 51 (91.1%) |
| Labour, n (%) | 60 (74.1%) |
| Labour type | |
| Vaginal | 43 (71.7%) |
| Cesarean | 17 (28.3%) |
| Labour indication | |
| Obstretic | 56 (93.3%) |
| Cardiac | 4 (6.6%) |
[i] NYHA, New York Heart Association.