Figure 1
PRISMA flow diagram of study selection process for this review.
Table 1
Characteristics of studies eligible for the systematic review.
| STUDY | COUNTRY | AGE GROUP | PRIMARY DIAGNOSIS | NUMBER OF HIV AMONG THE RHD CASES | REFERENCE | COMMENTS |
|---|---|---|---|---|---|---|
| DiCarlo et al., 1989 | United Sates | Adult | Case of IE | 1 case (case study) | [48] | Excluded from meta-analysis |
| Radcliffe et al., 1991 | United Kingdom | Adult, 25 years old | Case of IE | 1 case (case study) | [49] | Excluded from meta-analysis |
| Mesquita et al., 1996 | Brazil | Adult, 36 years old | A Case of RHD + HIV | 1 case (case study) | [45] | Excluded from meta-analysis |
| Vohra et al., 2014 | India | Adult, 21 years old | A case report of ARF + HIV | 1 case (case study) | [47] | Excluded from meta-analysis |
| Sathekge et al., 2015 | South Africa | 28 years old | 28-year-old HIV+ woman presented with productive cough, fever weight loss, and progressive dyspnoea class II to III for six months | 1 case (case study) | [46] | Excluded from meta-analysis |
| 1. Meel et al., 2017 | South Africa | Adult, 30–60 years old | RHD cohort in Soweto | 26 HIV/94 RHD | [34] | Included in meta-analysis |
| 2. Schwartz, 2012 | Botswana | Adults, 15–97 (mean 45 for RHDs) | Cardiomyopathy cohort | 7 HIV/15 RHD (of a cohort of 179 CVD referrals) | [29] | Included in meta-analysis |
| 3. Huck et al., 2016 | Uganda | 10–60 years old | Mixed: RHD+ and HIV+ | 21 HIV/115 RH adults | [36] | Included in meta-analysis |
| 4. Sliwa et al., 2010 | South Africa | Adults > 14 years old (97% > 20 years old) | RHD cohort | 23 HIV+/344 RHD cases of various ages, 14–70 years, but only 3% of cases were 14–19 years, so mainly adults | [14] | Included in meta-analysis |
| 5. Koegelenberg, 2003 | South Africa | Adults (mean age 37.7) | IE study cohort | 1 HIV+/36 RHD in a 47 IE cohort studied | [38] | Included in meta-analysis |
| 6. Dobe et al., 2020 | Mozambique | Adults, 18–75 years old | Study of HIV cohort | 6 RHD/468 HIV cases (6 of 88 who had evidence of CVD in the 468 HIV cohort) | [50] | Included in meta-analysis |
| 7. Sliwa et al., 2012 | South Africa | Adult CV disease (mean age 41 years old) | Heart disease in HIV-infected adults | 32 RHD/518 HIV adults | [51] | Included in meta-analysis |
| 8. Hovis et al., 2016 | Uganda | 5–15 years old | HIV vertically acquired cohort | 15 RHD/993 HIV children | [52] | Included in meta-analysis |
| 9. Glearson et al., 2017 | Uganda | 7–13 years old | HIV vertically infected children | 4 RHD/488 HIV children | [53] | Included in meta-analysis |
| 10. Manafe et al., 2019 | Mozambique | Children (median age 9 years old) | Vertically acquired HIV-infected children | 1 RHD/47 HIV children | [54] | Included in meta-analysis |
[i] Eligible published reports selected for the systematic review and meta-analysis.
Figure 2
RHD cohort: proportion of HIV infections in RHD cohorts.
Figure 3
RHD Cohort: proportion of HIV infections in RHD cohorts by country.
Figure 4
HIV infection cohort: proportion of RHD in HIV-infected cohorts, overall (4a) and by age (4b).
Figure 5
HIV infection cohort: proportion of RHD in HIV-infected cohorts by country.
Figure 6
CV risk modification in HIV infection.