
Nicotine and Cardiovascular Health: When Poison is Addictive – a WHF Policy Brief
References
- World Heart Federation.
World Heart Report 2023: Confronting the world’s number one killer [Internet] . Geneva, Switzerland: World Heart Federation; 2023. (World Heart Report). Report No.: 1.https://world-heart-federation.org/resource/world-heart-report-2023/ (accessed 16 Oct 2023). - Grainger Gasser A, Welch C, Arora M, Greenland R, Bhatti L, Sanda L, et al. Reducing cardiovascular mortality through tobacco control: A World Heart Federation Roadmap. Glob Heart. 2015 Jun 1; 10(2): 123. DOI: 10.1016/j.gheart.2015.04.007
- Institute for Health Metrics and Evaluation (IHME).
Global burden of disease . 2019; GBD Compare.https://vizhub.healthdata.org/gbd-compare/ (cited 31 Mar 2023). - World Health Organization.
WHO tobacco factsheet . World Health Organization; 2022.https://www.who.int/news-room/fact-sheets/detail/tobacco (accessed 22 Mar 2023). - Reitsma MB, Kendrick PJ, Ababneh E, Abbafati C, Abbasi-Kangevari M, Abdoli A, et al. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: A systematic analysis from the Global Burden of Disease Study 2019. The Lancet. 2021 Jun; 397(10292): 2337–60.
- Glantz SA.
Nicotine is not caffeine . Center for Tobacco Control Research and Education; 2014.https://tobacco.ucsf.edu/nicotine-not-caffeine (accessed 22 Mar 2023). - Becker R. Why Big Tobacco and Big Vape love comparing nicotine to caffeine – They’re apples and oranges. The Verge; 2019.
https://www.theverge.com/2019/4/26/18513312/vape-tobacco-big-companies-nicotine-caffeine-comparison-drugs-chemicals (accessed 16 Jun 2023). - Royal Society for Public Health. Nicotine “no more harmful to health than caffeine.” Royal Society for Public Health; 2015.
https://www.rsph.org.uk/about-us/news/nicotine--no-more-harmful-to-health-than-caffeine-.html (accessed 16 Jun 2023]. - Royal Society for Public Health. Stopping smoking by using other sources of nicotine; 2015.
https://www.rsph.org.uk/static/uploaded/d7f1aa02-3f33-4324-82bfb15d484d5354.pdf (accessed 19 Jul 2023). - Peralta AR, Guntur VP. Safety and efficacy of electronic cigarettes: A review. Mo Med. 2014; 111(3): 238–44.
- Harrison P. E-Cigarettes as safe as nicotine replacement in real-world study. Medscape. 2017 Feb 7;
https://www.medscape.com/viewarticle/875473 (accessed 19 Jul 2023). - Russell MA. Low-tar medium-nicotine cigarettes: A new approach to safer smoking. BMJ. 1976 Jun 12; 1(6023): 1430–3. DOI: 10.1136/bmj.1.6023.1430
- Philip Morris International. Exploring the smoke-free categories aimed at helping ALL adult smokers leave cigarettes behind for good. Philip Morris International.
https://www.pmi.com/pmis-multi-category-approach-toward-a-smoke-free-future/smoke-free-categories-explained (accessed 16 Jun 2023). - Grana R, Benowitz N, Glantz SA. E-Cigarettes: A scientific review. Circulation. 2014 May 13; 129(19): 1972–86. DOI: 10.1161/CIRCULATIONAHA.114.007667
- Benowitz NL, Burbank AD. Cardiovascular toxicity of nicotine: Implications for electronic cigarette use. Trends Cardiovasc Med. 2016 Aug; 26(6): 515–23. DOI: 10.1016/j.tcm.2016.03.001
- Harris B. The intractable cigarette ‘filter problem.’ Tob Control. 2011 May 1; 20(Supplement 1): i10–6. DOI: 10.1136/tc.2010.040113
- Blum A, Novotny T. The filter fraud: Debunking the myth of ‘Safer’ as a key new strategy of tobacco control. Tob Induc Dis. 2018 Mar; 116(1).
http://www.journalssystem.com/tid/The-filter-fraud-debunking-the-myth-of-8220-Safer-8221-as-a-key-new-strategy-of-tobacco,83988,0,2.html (accessed 9 2023 Apr 2023). DOI: 10.18332/tid/83988 - Evans-Reeves K, Lauber K, Hiscock R. The ‘filter fraud’ persists: The tobacco industry is still using filters to suggest lower health risks while destroying the environment. Tob Control. 2022 Aug; 31(e1): e80–2. DOI: 10.1136/tobaccocontrol-2020-056245
- Thun MJ, Burns DM. Health impact of ‘reduced yield’ cigarettes: A critical assessment of the epidemiological evidence. Tob Control. 2001; 10(Suppl 1): i4–11.
- Leavell NR. The low tar lie. Tob Control. 1999 Dec 1; 8(4): 433–7. DOI: 10.1136/tc.8.4.433
- Henningfield JE, Rose CA, Zeller M. Tobacco industry litigation position on addiction: Continued dependence on past views. Tob Control. 2006 Dec 1; 15(suppl_4): iv27–36. DOI: 10.1136/tc.2005.013789
- Wayne GF, Carpenter CM.
Tobacco industry manipulation of nicotine dosing . In: Henningfield JE, London ED, Pogun S (eds.), Nicotine psychopharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg; 2009. p. 457–85. (Handbook of Experimental Pharmacology; vol. 192).http://link.springer.com/10.1007/978-3-540-69248-5_16 (accessed 9 Apr 2023). DOI: 10.1007/978-3-540-69248-5_16 - Land T, Keithly L, Kane K, Chen L, Paskowsky M, Cullen D, et al. Recent increases in efficiency in cigarette nicotine delivery: Implications for tobacco control. Nicotine Tob Res. 2014 Jun; 16(6): 753–8. DOI: 10.1093/ntr/ntt219
- Chapman S, Simon Chapman AO. Vaping theology 6: There’s nicotine in potatoes and tomatoes, so should we restrict or ban them too? 2021.
https://simonchapman6.com/2021/03/09/vaping-advocates-say-the-darndest-things-6-theres-nicotine-in-potatoes-and-tomatoes-so-should-we-restrict-or-ban-them-too/ (accessed 21 Mar 2023). - Moldoveanu SC, Scott WA, Lawson DM. Nicotine analysis in several non-tobacco plant materials. Beitr Zur Tab Int Tob Res. 2016 Apr 1; 27(2): 54–9. DOI: 10.1515/cttr-2016-0008
- Sigma-Aldrich.
Nicotine – Safety data sheet . Sigma-Aldrich; 2022.https://www.sigmaaldrich.com/CH/en/sds/SIGMA/N3876 (accessed 9 Apr 2023). - Saitoh F, Noma M, Kawashima N. The alkaloid contents of sixty Nicotiana species. Phytochemistry. 1985; 24(3): 477–80. DOI: 10.1016/S0031-9422(00)80751-7
- Chaplin JF, Burk LG. Genetic approaches to varying chemical constituents in tobacco and smoke. Beitr Zur Tab Contrib Tob Res. 1977 Jan 1; 9(2).
https://www.degruyter.com/doi/10.2478/cttr-2013-0432 (accessed 10 Apr 2023). DOI: 10.2478/cttr-2013-0432 - Chaplin JF, Burk LG. Agronomic, chemical and smoke characteristics of flue-cured Tobacco lines with different levels of total alkaloids. In: Winston-Salem (ed.), United States. Cooperation Centre for Scientific Research Relative to Tobacco. 1982. p. 85. Available from:
https://www.coresta.org/abstracts/agronomic-chemical-and-smoke-characteristics-flue-cured-tobacco-lines-different-levels (accessed 6 Feb 2023). - Collins W, Hawks S. Principles of flue-cured tobacco production. HarperCollins Publishers; 1993.
- Tso TC.
Production, physiology, and biochemistry of tobacco plant . Beltsville, Md: IDEALS; 1990. - Chavdarian CG, Sanders EB, Bassfield RL. Synthesis of optically active nicotinoids. J Org Chem. 1982 Mar; 47(6): 1069–73. DOI: 10.1021/jo00345a034
- Nguyen LA, He H, Pham-Huy C. Chiral drugs: an overview. Int J Biomed Sci IJBS. 2006 Jun; 2(2): 85–100. DOI: 10.59566/IJBS.2006.2085
- Smith SW. Chiral toxicology: It’s the same thing…only different. Toxicol Sci. 2009 Jul; 110(1): 4–30. DOI: 10.1093/toxsci/kfp097
- CAS Common Chemistry. (-)-Nicotine CAS.
https://commonchemistry.cas.org/detail?cas_rn=54-11-5&search=Nicotine (accessed 6 Feb 2023). - Benowitz NL, Hukkanen J, Jacob P.
Nicotine chemistry, metabolism, kinetics and biomarkers . In: Henningfield JE, London ED, Pogun S (eds.), Nicotine psychopharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg; 2009. p. 29–60. (Hofmann FB (ed.). Handbook of Experimental Pharmacology; vol. 192).http://link.springer.com/10.1007/978-3-540-69248-5_2 (accessed 10 Apr 2023). DOI: 10.1007/978-3-540-69248-5_2 - Domino EF.
Pharmacological significance of nicotine . In: Analytical determination of nicotine and related compounds and their metabolites. Elsevier; 1999. p. 1–11.https://linkinghub.elsevier.com/retrieve/pii/B9780444500953500024 (accessed 10 Apr 2023). DOI: 10.1016/B978-044450095-3/50002-4 - Ji H, Wu Y, Fannin F, Bush L. Determination of tobacco alkaloid enantiomers using reversed phase UPLC/MS/MS. Heliyon. 2019 May; 5(5):
e01719 . DOI: 10.1016/j.heliyon.2019.e01719 - Hukkanen J, Jacob P, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev. 2005 Mar; 57(1): 79–115. DOI: 10.1124/pr.57.1.3
- Benowitz NL. Pharmacology of nicotine: Addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol. 2009; 49: 57–71. DOI: 10.1146/annurev.pharmtox.48.113006.094742
- Gholap VV, Kosmider L, Golshahi L, Halquist MS. Nicotine forms: Why and how do they matter in nicotine delivery from electronic cigarettes? Expert Opin Drug Deliv. 2020 Dec 1; 17(12): 1727–36. DOI: 10.1080/17425247.2020.1814736
- Hellinghausen G, Lee JT, Weatherly CA, Lopez DA, Armstrong DW. Evaluation of nicotine in tobacco-free-nicotine commercial products: Nicotine enantiomers in tobacco free nicotine. Drug Test Anal. 2017 Jun; 9(6): 944–8. DOI: 10.1002/dta.2145
- Ramamurthi D, Chau C, Lu Z, Rughoobur I, Sanaie K, Krishna P, et al.
Marketing of “Tobacco-Free” and “Synthetic Nicotine” Products . Stanford Research into the Impact of Tobacco Advertising; 2022.https://tobacco-img.stanford.edu/wp-content/uploads/2022/03/13161808/Synthetic-Nicotine-White-Paper-3-8-2022F.pdf (accessed 17 Feb 2023). - Chen Y, Sun S, Zhao X, Zhou H, Wang F. Objective facts or misleading hype? Associations between features of e-cigarette marketing and sales on a Chinese e-commerce platform. Int J Environ Res Public Health. 2020 Sep 15; 17(18): 6711. DOI: 10.3390/ijerph17186711
- Schmid T. A real up and comer: Synthetic nicotine. Tobacco Asia; 2021.
https://www.tobaccoasia.com/features/a-real-up-and-comer-synthetic-nicotine/ (accessed 6 Feb 2023). - Jordt SE. Synthetic nicotine has arrived. Tob Control. 2023 Apr; 32(e1): e113–7. DOI: 10.1136/tobaccocontrol-2021-056626
- Gupta AK, Mehrotra R. Safety concerns for tobacco-free products containing synthetic nicotine. Nicotine Tob Res Off J Soc Res Nicotine Tob. 2021 Oct 7; 23(11): 1980–1. DOI: 10.1093/ntr/ntab071
- Zettler PJ, Hemmerich N, Berman ML. Closing the regulatory gap for synthetic nicotine products. Boston Coll Law Rev Boston Coll Law Sch. 2018; 59(6): 1933–82. DOI: 10.1001/jamahealthforum.2022.1140
- Stephenson J. FDA gains power to regulate synthetic nicotine in e-cigarettes. JAMA Health Forum. 2022 Apr 1; 3(4):
e221140 . DOI: 10.1001/jamahealthforum.2022.1140 - Duell AK, Kerber PJ, Luo W, Peyton DH. Determination of (R)-(+)- and (S)-(-)-nicotine chirality in puff bar e-liquids by 1H NMR spectroscopy, polarimetry, and gas chromatography-mass spectrometry. Chem Res Toxicol. 2021 Jul 19; 34(7): 1718–20. DOI: 10.1021/acs.chemrestox.1c00192
- National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health.
The health consequences of smoking—50 years of progress: A report of the Surgeon General . Atlanta, GA: Centers for Disease Control and Prevention (US); 2014. (Reports of the Surgeon General). Available from:http://www.ncbi.nlm.nih.gov/books/NBK179276/ (accessed 11 Apr 2023). - Bellew B, Winnall W, Hanley-Jones S, Greenhalgh E, Winstanley M.
Health effects of smoking tobacco in other forms . In: Greenhalgh E, Scollo M, Winstanley M (eds.), Tobacco in Australia: Facts and issues. Melbourne: Cancer Council Victoria; 2021.https://www.tobaccoinaustralia.org.au/chapter-3-health-effects/3-27-health-effects-of-smoking-tobacco-in-other-fo . - Simonavicius E, McNeill A, Shahab L, Brose LS. Heat-not-burn tobacco products: A systematic literature review. Tob Control. 2019 Sep; 28(5): 582–94. DOI: 10.1136/tobaccocontrol-2018-054419
- Voos N, Goniewicz ML, Eissenberg T. What is the nicotine delivery profile of electronic cigarettes? Expert Opin Drug Deliv. 2019 Nov 2; 16(11): 1193–203. DOI: 10.1080/17425247.2019.1665647
- Marchand M, Brossard P, Merdjan H, Lama N, Weitkunat R, Lüdicke F. Nicotine population pharmacokinetics in healthy adult smokers: A retrospective analysis. Eur J Drug Metab Pharmacokinet. 2017 Dec; 42(6): 943–54. DOI: 10.1007/s13318-017-0405-2
- Sosnoff CS, Caron K, Akins JR, Dortch K, Hunter RE, Pine BN, et al. Serum concentrations of cotinine and trans-3′-hydroxycotinine in US adults: Results from wave 1 (2013–2014) of the Population Assessment of Tobacco and Health Study. Nicotine Tob Res. 2022 Mar 26; 24(5): 736–44. DOI: 10.1093/ntr/ntab240
- Murphy SE. Biochemistry of nicotine metabolism and its relevance to lung cancer. J Biol Chem. 2021 Jan; 296: 100722. DOI: 10.1016/j.jbc.2021.100722
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Personal habits and indoor combustions. IARC Monogr Eval Carcinog Risks Hum. 2012; 100(Pt E): 1–538.
- World Health Organization.
WHO study group on tobacco product regulation: Report on the scientific basis of tobacco product regulation: Sixth report of a WHO study group . Geneva: World Health Organization; 2017. (WHO technical report series; 1001).https://apps.who.int/iris/handle/10665/260245 (accessed 21 Apr 2023). - National Cancer Institute.
Smokeless tobacco or health: An international perspective . Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute; 1992. (Tobacco Control Monograph No. 2).https://cancercontrol.cancer.gov/brp/tcrb/monographs/monograph-02 . - Rostron BL, Chang JT, Anic GM, Tanwar M, Chang CM, Corey CG. Smokeless tobacco use and circulatory disease risk: A systematic review and meta-analysis. Open Heart. 2018 Nov; 5(2) :
e000846 . DOI: 10.1136/openhrt-2018-000846 - Piano MR, Benowitz NL, FitzGerald GA, Corbridge S, Heath J, Hahn E, et al. Impact of smokeless tobacco products on cardiovascular disease: Implications for policy, prevention, and treatment: A policy statement from the American Heart Association. Circulation. 2010 Oct 12; 122(15): 1520–44. DOI: 10.1161/CIR.0b013e3181f432c3
- Scientific Standards for Studies on Modified Risk Tobacco Products. Washington, DC: National Academies Press; 2012.
http://www.nap.edu/catalog/13294 (accessed 10 Apr 2023). - Abrams DB, Glasser AM, Pearson JL, Villanti AC, Collins LK, Niaura RS. Harm Minimization and Tobacco Control: Reframing Societal Views of Nicotine Use to Rapidly Save Lives. Annu Rev Public Health. 2018 Apr 1; 39(1): 193–213. DOI: 10.1146/annurev-publhealth-040617-013849
- Raja J, Khouzam A, Khouzam N, Khouzam RN. Smoke and heart should stay apart: A look at e-cigarettes and other alternatives to conventional cigarettes, and their impact on cardiovascular health. Curr Probl Cardiol. 2021 Mar; 46(3): 100640. DOI: 10.1016/j.cpcardiol.2020.100640
- Mears MJ, Hookfin HL, Bandaru P, Vidal P, Stanford KI, Wold LE. Electronic nicotine delivery systems and cardiovascular/cardiometabolic health. Circ Res. 2023 Apr 28; 132(9): 1168–80. DOI: 10.1161/CIRCRESAHA.123.321565
- Loffredo L, Carnevale R, Battaglia S, Marti R, Pizzolo S, Bartimoccia S, et al. Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: The SUR-VAPES Chronic Study. Thorax. 2021 Jun; 76(6): 618–20. DOI: 10.1136/thoraxjnl-2020-215900
- Sohal SS, Eapen MS, Naidu VGM, Sharma P. IQOS exposure impairs human airway cell homeostasis: Direct comparison with traditional cigarette and e-cigarette. ERJ Open Res. 2019 Feb; 5(1): 00159–2018. DOI: 10.1183/23120541.00159-2018
- World Health Organization.
WHO global report on trends in prevalence of tobacco use 2000–2025 . 3rd ed. Geneva: World Health Organization; 2019.https://apps.who.int/iris/handle/10665/330221 (accessed 10 Apr 2023). - Tehrani H, Rajabi A, Ghelichi- Ghojogh M, Nejatian M, Jafari A. The prevalence of electronic cigarettes vaping globally: A systematic review and meta-analysis. Arch Public Health. 2022 Nov 21; 80(1): 240. DOI: 10.1186/s13690-022-00998-w
- Laverty AA, Vardavas CI, Filippidis FT. Prevalence and reasons for use of Heated Tobacco Products (HTP) in Europe: An analysis of Eurobarometer data in 28 countries. Lancet Reg Health – Eur. 2021 Sep; 8: 100159. DOI: 10.1016/j.lanepe.2021.100159
- Eissenberg T, Bhatnagar A, Chapman S, Jordt SE, Shihadeh A, Soule EK. Invalidity of an oft-cited estimate of the relative harms of electronic cigarettes. Am J Public Health. 2020 Feb; 110(2): 161–2. DOI: 10.2105/AJPH.2019.305424
- United States. editor.
How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: A report of the Surgeon General. Rockville, MD; Washington, DC: U.S . Dept. of Health and Human Services, Public Health Service, Office of the Surgeon General. For sale by the Supt. of Docs., U.S. G.P.O; 2010. - Centers for Disease Control and Prevention.
Bidis and Kreteks . Centers for Disease Control and Prevention; 2018.https://www.cdc.gov/tobacco/data_statistics/fact_sheets/tobacco_industry/bidis_kreteks/index.htm (accessed 17 Feb 2023). - Teutsch SM, Geller AB, Mead AM, National Academies of Sciences, Engineering, and Medicine (U.S.). editors.
Premium cigars: Patterns of use, marketings, and health effects . (A consensus study report). Washington, DC: The National Academies Press; 2022. DOI: 10.17226/26421 - Vupputuri S, Hajat C, Al-Houqani M, Osman O, Sreedharan J, Ali R, et al. Midwakh/dokha tobacco use in the Middle East: much to learn. Tob Control. 2016 Mar; 25(2): 236–41. DOI: 10.1136/tobaccocontrol-2013-051530
- U.S. Food and Drug Administration.
Hookah tobacco (shisha or waterpipe tobacco) . U.S. Food and Drug Administration; 2020.https://www.fda.gov/tobacco-products/products-ingredients-components/hookah-tobacco-shisha-or-waterpipe-tobacco (accessed 17 Feb 2023). - Bianco E, Skipalskyi A, Goma F, Odeh H, Hasegawa K, Zawawi MA, et al. E-cigarettes: A new threat to cardiovascular health – A World Heart Federation Policy Brief. Glob Heart. 2021 Oct 18; 16(1): 72. DOI: 10.5334/gh.1076
- Hedman L, Galanti M, Ryk L, Gilljam H, Adermark L. Electronic cigarette use and smoking cessation in cohort studies and randomized trials: A systematic review and meta-analysis. Tob Prev Cessat. 2021 Oct 13; 7(October): 1–16. DOI: 10.18332/tpc/142320
- Banks E, Yazidjoglou A, Brown S, Nguyen M, Martin M, Beckwith K, et al. Electronic cigarettes and health outcomes: Umbrella and systematic review of the global evidence. Med J Aust. 2023 Apr 3; 218(6): 267–75. DOI: 10.5694/mja2.51890
- Wang RJ, Bhadriraju S, Glantz SA. E-Cigarette use and adult cigarette smoking cessation: A meta-analysis. Am J Public Health. 2021 Feb; 111(2): 230–46. DOI: 10.1007/s40429-022-00448-1
- Coleman SRM, Piper ME, Byron MJ, Bold KW. Dual use of combustible cigarettes and e-cigarettes: A narrative review of current evidence. Curr Addict Rep. 2022 Oct 17; 9(4): 353–62. DOI: 10.1007/s40429-022-00448-1
- Owusu D, Huang J, Weaver SR, Pechacek TF, Ashley DL, Nayak P, et al. Patterns and trends of dual use of e-cigarettes and cigarettes among U.S. adults, 2015–2018. Prev Med Rep. 2019 Dec; 16: 101009. DOI: 10.1016/j.pmedr.2019.101009
- World Health Organization.
WHO Report on the Global Tobacco Epidemic 2021: Addressing new and emerging products . Geneva, Switzerland: World Health Organization; 2021.https://www.who.int/publications/i/item/9789240032095 (accessed 16 Jun 2023). - Jackler R, Ramamurthi D, Axelrod A, Jung J, Louis-Ferdinand N, Reide J, et al. The Philip Morris campaign to popularize “heat not burn” tobacco. Stanford research into the impact of tobacco advertising; 2020.
https://tobacco-img.stanford.edu/wp-content/uploads/2021/07/21231822/IQOS_Paper_2-21-2020F.pdf (accessed 17 Feb 2023). - Duan Z, Le D, Ciceron AC, Dickey-Chasins R, Wysota CN, Bar-Zeev Y, et al. ‘It’s like if a vape pen and a cigarette had a baby’: A mixed methods study of perceptions and use of IQOS among US young adults. Health Educ Res. 2022 Sep 23; 37(5): 364–77. DOI: 10.1093/her/cyac019
- Odani S, Tsuno K, Agaku IT, Tabuchi T. Heated tobacco products do not help smokers quit or prevent relapse: A longitudinal study in Japan. Tob Control. 2023 Feb 27; tc-2022-057613. DOI: 10.1136/tc-2022-057613
- Centers for Disease Control and Prevention.
Dissolvable tobacco products . Centers for Disease Control and Prevention; 2018.https://www.fda.gov/tobacco-products/products-ingredients-components/dissolvable-tobacco-products (accessed 17 Feb 2023). - Borowiecki M, Emery SL, Kostygina G. New recreational nicotine lozenges, tablets, gummies and gum proliferate on the US market. Tob Control. 2022 Nov 1; c-2022–057673. DOI: 10.1136/tc-2022-057673
- Shaikh SB, Newton C, Tung WC, Sun Y, Li D, Ossip D, et al. Classification, perception, and toxicity of emerging flavored oral nicotine pouches. Int J Environ Res Public Health. 2023 Mar 3; 20(5): 4526. DOI: 10.3390/ijerph20054526
- Guo QN, Wang J, Liu HY, Wu D, Liao SX. Nicotine ingestion reduces heart rate variability in young healthy adults. In: Formanowicz D, (ed.), BioMed Res Int. 2022 Jan 4; 2022: 1–7. DOI: 10.1155/2022/4286621
- Whitehead AK, Erwin AP, Yue X. Nicotine and vascular dysfunction. Acta Physiol Oxf Engl. 2021 Apr; 231(4):
e13631 . DOI: 10.1111/apha.13631 - Ljungberg LU, Persson K, Eriksson AC, Green H, Whiss PA. Effects of nicotine, its metabolites and tobacco extracts on human platelet function in vitro. Toxicol Vitro Int J Publ Assoc BIBRA. 2013 Mar; 27(2): 932–8. DOI: 10.1016/j.tiv.2013.01.004
- Schmidt F, Daiber A, Münzel T. Long-term cardiovascular risk of e-cigarettes. Eur Heart J. 2020 Apr 14; 41(15): 1526–1526. DOI: 10.1093/eurheartj/ehaa079
- Buchanan ND, Grimmer JA, Tanwar V, Schwieterman N, Mohler PJ, Wold LE. Cardiovascular risk of electronic cigarettes: A review of preclinical and clinical studies. Cardiovasc Res. 2020 Jan 1; 116(1): 40–50. DOI: 10.1001/jamacardio.2016.5303
- Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, et al. Increased cardiac sympathetic activity and oxidative stress in habitual electronic cigarette users: Implications for cardiovascular risk. JAMA Cardiol. 2017 Mar 1; 2(3): 278–84. DOI: 10.1001/jamacardio.2016.5303
- Benowitz NL. The role of nicotine in smoking-related cardiovascular disease. Prev Med. 1997; 26(4): 412–7. DOI: 10.1006/pmed.1997.0175
- Zhu BQ, Parmley WW. Hemodynamic and vascular effects of active and passive smoking. Am Heart J. 1995 Dec; 130(6): 1270–5. DOI: 10.1016/0002-8703(95)90154-X
- Czernin J, Waldherr C. Cigarette smoking and coronary blood flow. Prog Cardiovasc Dis. 2003; 45(5): 395–404. DOI: 10.1016/S0033-0620(03)80003-8
- Messner B, Bernhard D. Smoking and cardiovascular disease: Mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3): 509–15. DOI: 10.1161/ATVBAHA.113.300156
- Rao ChS. The effect of chronic tobacco smoking and chewing on the lipid profile. J Clin Diagn Res; 2013.
http://www.jcdr.net/article_fulltext.asp?issn=0973-709x&year=2013&month=January&volume=7&issue=1&page=31-34&id=2663 (accessed 10 Apr 2023). - Aune D, Schlesinger S, Norat T, Riboli E. Tobacco smoking and the risk of heart failure: A systematic review and meta-analysis of prospective studies. Eur J Prev Cardiol. 2019 Feb; 26(3): 279–88. DOI: 10.1177/2047487318806658
- Chamberlain AM, Agarwal SK, Folsom AR, Duval S, Soliman EZ, Ambrose M, et al. Smoking and incidence of atrial fibrillation: Results from the Atherosclerosis Risk in Communities (ARIC) study. Heart Rhythm. 2011 Aug; 8(8): 1160–6. DOI: 10.1016/j.hrthm.2011.03.038
- D’Alessandro A, Boeckelmann I, Hammwhöner M, Goette A. Nicotine, cigarette smoking and cardiac arrhythmia: An overview. Eur J Prev Cardiol. 2012 Jun; 19(3): 297–305. DOI: 10.1177/1741826711411738
- Hom S, Chen L, Wang T, Ghebrehiwet B, Yin W, Rubenstein DA. Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations. Platelets. 2016 Oct 2; 27(7): 694–702. DOI: 10.3109/09537104.2016.1158403
- Ramirez JEM, Karim ZA, Alarabi AB, Hernandez KR, Taleb ZB, Rivera JO, et al. The JUUL e-cigarette elevates the risk of thrombosis and potentiates platelet activation. J Cardiovasc Pharmacol Ther. 2020 Nov; 25(6): 578–86. DOI: 10.1177/1074248420941681
- Bennani I, Alami Chentoufi M, El Karbane M, Cheikh A, Bouatia M. E-Cigarette quality control: Impurity and nicotine level analysis in electronic cigarette refill liquids. Sci World J. 2020 Apr 13; 2020: 1–7. DOI: 10.1155/2020/3050189
- Son Y, Weisel C, Wackowski O, Schwander S, Delnevo C, Meng Q. The impact of device settings, use patterns, and flavorings on carbonyl emissions from electronic cigarettes. Int J Environ Res Public Health. 2020 Aug 5; 17(16): 5650. DOI: 10.3390/ijerph17165650
- Guerrero-Cignarella A, Luna Diaz LV, Balestrini K, Holt G, Mirsaeidi M, Calderon-Candelario R, et al. Differences in vaping topography in relation to adherence to exclusive electronic cigarette use in veterans. In: Niaura R (ed.), PLOS ONE. 2018 Apr 25; 13(4):
e0195896 . DOI: 10.1371/journal.pone.0195896 - Skotsimara G, Antonopoulos AS, Oikonomou E, Siasos G, Ioakeimidis N, Tsalamandris S, et al. Cardiovascular effects of electronic cigarettes: A systematic review and meta-analysis. Eur J Prev Cardiol. 2019 Jul; 26(11): 1219–28. DOI: 10.1177/2047487319832975
- Vlachopoulos C, Ioakeimidis N, Abdelrasoul M, Terentes-Printzios D, Georgakopoulos C, Pietri P, et al. Electronic cigarette smoking increases aortic stiffness and blood pressure in young smokers. J Am Coll Cardiol. 2016 Jun; 67(23): 2802–3. DOI: 10.1016/j.jacc.2016.03.569
- Tsai M, Byun MK, Shin J, Crotty Alexander LE. Effects of e-cigarettes and vaping devices on cardiac and pulmonary physiology. J Physiol. 2020 Nov; 598(22): 5039–62. DOI: 10.1113/JP279754
- Qasim H, Karim ZA, Silva-Espinoza JC, Khasawneh FT, Rivera JO, Ellis CC, et al. Short-term e-cigarette exposure increases the risk of thrombogenesis and enhances platelet function in mice. J Am Heart Assoc. 2018 Jul 18; 7(15):
e009264 . DOI: 10.1161/JAHA.118.009264 - Alzahrani T, Pena I, Temesgen N, Glantz SA. Association between electronic cigarette use and myocardial infarction. Am J Prev Med. 2018 Oct; 55(4): 455–61. DOI: 10.1016/j.amepre.2018.05.004
- Skaug EA, Nes B, Aspenes ST, Ellingsen Ø. Non-smoking tobacco affects endothelial function in healthy men in one of the largest health studies ever performed: The Nord-Trøndelag Health Study in Norway; HUNT3. Schooling CM (ed.), PLOS ONE. 2016 Aug 4; 11(8):
e0160205 . DOI: 10.1371/journal.pone.0160205 - Janzon E, Hedblad B. Swedish snuff and incidence of cardiovascular disease. A population-based cohort study. BMC Cardiovasc Disord. 2009 Dec; 9(1): 21. DOI: 10.1186/1471-2261-9-21
- Titova OE, Baron JA, Michaëlsson K, Larsson SC. Swedish snuff (snus) and risk of cardiovascular disease and mortality: Prospective cohort study of middle-aged and older individuals. BMC Med. 2021 Dec; 19(1): 111. DOI: 10.1186/s12916-021-01979-6
- Vidyasagaran AL, Siddiqi K, Kanaan M. Use of smokeless tobacco and risk of cardiovascular disease: A systematic review and meta-analysis. Eur J Prev Cardiol. 2016 Dec; 23(18): 1970–81. DOI: 10.1177/2047487316654026
- Haglund B, Eliasson M, Stenbeck M, Rosen M. Is moist snuff use associated with excess risk of IHD or stroke? A longitudinal follow-up of snuff users in Sweden. Scand J Public Health. 2007 Dec; 35(6): 618–22. DOI: 10.1080/14034940701436949
- Hajat C, Stein E, Ramstrom L, Shantikumar S, Polosa R. The health impact of smokeless tobacco products: A systematic review. Harm Reduct J. 2021 Dec 4; 18(1): 123. DOI: 10.1186/s12954-021-00557-6
- Hansson J, Galanti MR, Hergens MP, Fredlund P, Ahlbom A, Alfredsson L, et al. Snus (Swedish smokeless tobacco) use and risk of stroke: Pooled analyses of incidence and survival. J Intern Med. 2014 Jul; 276(1): 87–95. DOI: 10.1111/joim.12219
- Vardavas CI, Girvalaki C, Filippidis FT, Oder M, Kastanje R, de Vries I, et al. Characteristics and outcomes of e-cigarette exposure incidents reported to 10 European Poison Centers: A retrospective data analysis. Tob Induc Dis. 2017 Dec; 15(1): 36. DOI: 10.1186/s12971-017-0141-z
- Maessen GC, Wijnhoven AM, Neijzen RL, Paulus MC, van Heel DAM, Bomers BHA, et al. Nicotine intoxication by e-cigarette liquids: A study of case reports and pathophysiology. Clin Toxicol. 2020 Jan 2; 58(1): 1–8. DOI: 10.1080/15563650.2019.1636994
- Wang B, Liu S, Persoskie A. Poisoning exposure cases involving e-cigarettes and e-liquid in the United States, 2010–2018. Clin Toxicol. 2020 Jun 2; 58(6): 488–94. DOI: 10.1080/15563650.2019.1661426
- Scarpino M, Rosso T, Lanzo G, Lolli F, Bonizzoli M, Lazzeri C, et al. Severe neurological nicotine intoxication by e-cigarette liquids: Systematic literature review. Acta Neurol Scand. 2021 Feb; 143(2): 121–30. DOI: 10.1111/ane.13338
- Barbuto A. Nicotine poisoning (e-cigarettes, tobacco products, plants, and pesticides). UpToDate; 2022.
https://www.uptodate.com/contents/nicotine-poisoning-e-cigarettes-tobacco-products-plants-and-pesticides#H958306386 (accessed 17 Feb 2023). - Barrington-Trimis JL, Braymiller JL, Unger JB, McConnell R, Stokes A, Leventhal AM, et al. Trends in the age of cigarette smoking initiation among young adults in the US From 2002 to 2018. JAMA Netw Open. 2020 Oct 6; 3(10):
e2019022 . DOI: 10.1001/jamanetworkopen.2020.19022 - Walley SC, Wilson KM, Winickoff JP, Groner J. A public health crisis: Electronic cigarettes, vape, and JUUL. Pediatrics. 2019 Jun; 143(6):
e20182741 . DOI: 10.15585/mmwr.mm7140a3 - Cooper M, Park-Lee E, Ren C, Cornelius M, Jamal A, Cullen KA. Notes from the field: E-cigarette use among middle and high school students — United States, 2022. MMWR Morb Mortal Wkly Rep. 2022 Oct 7; 71(40): 1283–5. DOI: 10.15585/mmwr.mm7140a3
- Glantz S, Jeffers A, Winickoff JP. Nicotine addiction and intensity of e-cigarette use by adolescents in the US, 2014 to 2021. JAMA Netw Open. 2022 Nov 7; 5(11):
e2240671 . DOI: 10.1001/jamanetworkopen.2022.40671 - Health Canada.
Summary of results for the Canadian Student Tobacco, Alcohol and Drugs Survey 2021–22 . Government of Canada; 2023.https://www.canada.ca/en/health-canada/services/canadian-student-tobacco-alcohol-drugs-survey/2021-2022-summary.html (accessed 16 Jun 2023). - Dani JA.
Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine . In: International Review of Neurobiology. Elsevier; 2015. p. 3–19.https://linkinghub.elsevier.com/retrieve/pii/S0074774215000471 (accessed 10 Apr 2023). DOI: 10.1016/bs.irn.2015.07.001 - Castro EM, Lotfipour S, Leslie FM. Nicotine on the developing brain. Pharmacol Res. 2023 Apr; 190: 106716. DOI: 10.1016/j.phrs.2023.106716
- England LJ, Bunnell RE, Pechacek TF, Tong VT, McAfee TA. Nicotine and the developing human: A neglected element in the electronic cigarette debate. Am J Prev Med. 2015 Aug; 49(2): 286–93. DOI: 10.1016/j.amepre.2015.01.015
- Kota D, Martin BR, Robinson SE, Damaj MI. Nicotine dependence and reward differ between adolescent and adult male mice. J Pharmacol Exp Ther. 2007 Jul; 322(1): 399–407. DOI: 10.1124/jpet.107.121616
- Azam L, Chen Y, Leslie FM. Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons. Neuroscience. 2007 Feb; 144(4): 1347–60. DOI: 10.1016/j.neuroscience.2006.11.011
- Adriani W, Spijker S, Deroche-Gamonet V, Laviola G, Le Moal M, Smit AB, et al. Evidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats. J Neurosci Off J Soc Neurosci. 2003 Jun 1; 23(11): 4712–6. DOI: 10.1016/j.neuropharm.2016.06.026
- Gellner CA, Belluzzi JD, Leslie FM. Self-administration of nicotine and cigarette smoke extract in adolescent and adult rats. Neuropharmacology. 2016 Oct; 109: 247–53. DOI: 10.1016/j.neuropharm.2016.06.026
- Counotte DS, Goriounova NA, Li KW, Loos M, van der Schors RC, Schetters D, et al. Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence. Nat Neurosci. 2011 Apr; 14(4): 417–9. DOI: 10.1038/nn.2770
- Iñiguez SD, Warren BL, Parise EM, Alcantara LF, Schuh B, Maffeo ML, et al. Nicotine exposure during adolescence induces a depression-like state in adulthood. Neuropsychopharmacology. 2009 May; 34(6): 1609–24. DOI: 10.1038/npp.2008.220
- Leslie FM. Unique, long-term effects of nicotine on adolescent brain. Pharmacol Biochem Behav. 2020 Oct; 197: 173010. DOI: 10.1016/j.pbb.2020.173010
- Yuan M, Cross SJ, Loughlin SE, Leslie FM. Nicotine and the adolescent brain. J Physiol. 2015 Aug 15; 593(16): 3397–412. DOI: 10.1113/JP270492
- Chadi N, Li G, Hadland SE. Adverse school outcomes and risky sexual health behaviors among high school students with e-cigarette and marijuana use. Subst Use Misuse. 2021 Mar 21; 56(4): 517–21. DOI: 10.1080/10826084.2021.1883659
- McCabe SE, West BT, Veliz P, Boyd CJ. E-cigarette use, cigarette smoking, dual use, and problem behaviors among U.S. adolescents: Results from a national survey. J Adolesc Health. 2017 Aug; 61(2): 155–62. DOI: 10.1016/j.jadohealth.2017.02.004
- Dearfield CT, Chen-Sankey JC, McNeel TS, Bernat DH, Choi K. E-cigarette initiation predicts subsequent academic performance among youth: Results from the PATH Study. Prev Med. 2021 Dec; 153: 106781. DOI: 10.1016/j.ypmed.2021.106781
- Mishra A, Chaturvedi P, Datta S, Sinukumar S, Joshi P, Garg A. Harmful effects of nicotine. Indian J Med Paediatr Oncol. 2015 Jan; 36(01): 24–31. DOI: 10.4103/0971-5851.151771
- Jarvis MJ. Passive smoking in the home: Plasma cotinine concentrations in non-smokers with smoking partners. Tob Control. 2001 Dec 1; 10(4): 368–74. DOI: 10.1136/tc.10.4.368
- Gallo V, Neasham D, Airoldi L, Ferrari P, Jenab M, Boffetta P, et al. Second-hand smoke, cotinine levels, and risk of circulatory mortality in a large cohort study of never-smokers. Epidemiology. 2010 Mar; 21(2): 207–14. DOI: 10.1097/EDE.0b013e3181c9fdad
- Melstrom P, Sosnoff C, Koszowski B, King BA, Bunnell R, Le G, et al. Systemic absorption of nicotine following acute secondhand exposure to electronic cigarette aerosol in a realistic social setting. Int J Hyg Environ Health. 2018 Jun; 221(5): 816–22. DOI: 10.1016/j.scitotenv.2022.158668
- Amalia B, Fu M, Tigova O, Ballbè M, Paniello-Castillo B, Castellano Y, et al. Exposure to secondhand aerosol from electronic cigarettes at homes: A real-life study in four European countries. Sci Total Environ. 2023 Jan; 854: 158668. DOI: 10.1016/j.scitotenv.2022.158668
- Scientific Committee on Health, Environmental, and Emerging Risks.
Opinion on electronic cigarettes . Scientific Committee on Health, Environmental, and Emerging Risks; 2021.https://health.ec.europa.eu/system/files/2022-08/scheer_o_017.pdf (accessed 10 Apr 2023). - Fernández E, Fu M, Martínez-Sánchez J.
Exposure to aerosols from smoking-proxy electronic inhaling systems: A systematic review . Barcelona: World Health Organization Tobacco Free Initiative; 2016 Sep.https://cdn.who.int/media/docs/default-source/regulating-tobacco-products/backgroundpapersends1-4november.pdf?sfvrsn=e8ddac84_4 (accessed 10 Apr 2023). - Hess IM, Lachireddy K, Capon A. A systematic review of the health risks from passive exposure to electronic cigarette vapour. Public Health Res Pract. 2016 Apr 15; 26(2): 2621617. DOI: 10.17061/phrp2621617
- World Health Organization.
International classification of diseases for mortality and morbidity statistics (ICD-11) . Eleventh Revision. Geneva: World Health Organization; 2022.https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1699574100 (accessed 17 Feb 2023). - Van Zundert RMP, Boogerd EA, Vermulst AA, Engels RCME. Nicotine withdrawal symptoms following a quit attempt: An ecological momentary assessment study among adolescents. Nicotine Tob Res. 2009 Jun; 11(6): 722–9. DOI: 10.1093/ntr/ntp055
- Markou A. Neurobiology of nicotine dependence. Philos Trans R Soc B Biol Sci. 2008 Oct 12; 363(1507): 3159–68. DOI: 10.1098/rstb.2008.0095
- Carter LP, Stitzer ML, Henningfield JE, O’Connor RJ, Cummings KM, Hatsukami DK. Abuse liability assessment of tobacco products including potential reduced exposure products. Cancer Epidemiol Biomarkers Prev. 2009 Dec 1; 18(12): 3241–62. DOI: 10.1158/1055-9965.EPI-09-0948
- Hiler M, Breland A, Spindle T, Maloney S, Lipato T, Karaoghlanian N, et al. Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience. Exp Clin Psychopharmacol. 2017 Oct; 25(5): 380–92. DOI: 10.1037/pha0000140
- World Health Organization.
Advisory note: Global nicotine reduction strategy: WHO Study Group on Tobacco Product Regulation . Geneva: World Health Organization; 2015.https://apps.who.int/iris/handle/10665/189651 (accessed 11 Apr 2023). - Jarvis MJ. Why people smoke. BMJ. 2004 Jan 31; 328(7434): 277–9. DOI: 10.1136/bmj.328.7434.277
- Benowitz NL, Henningfield JE. Reducing the nicotine content to make cigarettes less addictive. Tob Control. 2013 May; 22(suppl 1): i14–7. DOI: 10.1136/tobaccocontrol-2012-050860
- Bahelah R, DiFranza JR, Ward KD, Eissenberg T, Fouad FM, Taleb ZB, et al. Waterpipe smoking patterns and symptoms of nicotine dependence: The Waterpipe Dependence in Lebanese Youth Study. Addict Behav. 2017 Nov; 74: 127–33. DOI: 10.1016/j.addbeh.2017.06.003
- Al Sharbatti S, Shaikh RB, Sreedharan J, Muttappallymyalil J, Weizman M. Predictors of nicotine dependence among adult male midwakh and cigarette smokers. Sultan Qaboos Univ Med J SQUMJ. 2021 Apr 18;
https://journals.squ.edu.om/index.php/squmj/article/view/4244 (accessed 11 Apr 2023). DOI: 10.18295/squmj.4.2021.064 - Kechter A, Cho J, Miech RA, Barrington-Trimis JL, Leventhal AM. Nicotine dependence symptoms in U.S. youth who use JUUL E-cigarettes. Drug Alcohol Depend. 2021 Oct; 227: 108941. DOI: 10.1016/j.drugalcdep.2021.108941
- Prochaska JJ, Vogel EA, Benowitz N. Nicotine delivery and cigarette equivalents from vaping a JUULpod. Tob Control. 2022 Aug; 31(e1): e88–93. DOI: 10.1136/tobaccocontrol-2020-056367
- Grøtvedt L, Forsén L, Ariansen I, Graff-Iversen S, Lingaas Holmen T. Impact of snus use in teenage boys on tobacco use in young adulthood: A cohort from the HUNT Study Norway. BMC Public Health. 2019 Dec; 19(1): 1265. DOI: 10.1186/s12889-019-7584-5
- Herman M, Tarran R. E-cigarettes, nicotine, the lung and the brain: Multi-level cascading pathophysiology. J Physiol. 2020 Nov; 598(22): 5063–71. DOI: 10.1113/JP278388
- Park E, Livingston JA, Wang W, Kwon M, Eiden RD, Chang YP. Adolescent e-cigarette use trajectories and subsequent alcohol and marijuana use. Addict Behav. 2020 Apr; 103: 106213. DOI: 10.1016/j.drugalcdep.2020.108496
- Lozano A, Liu F, Lee TK, Prado G, Schwartz SJ, Leventhal AM, et al. Bidirectional associations between e-cigarette use and alcohol use across adolescence. Drug Alcohol Depend. 2021 Mar; 220: 108496. DOI: 10.1016/j.drugalcdep.2020.108496
- Roche DJO, Bujarski S, Green R, Hartwell EE, Leventhal AM, Ray LA. Alcohol, tobacco, and marijuana consumption is associated with increased odds of same-day substance co- and tri-use. Drug Alcohol Depend. 2019 Jul; 200: 40–9. DOI: 10.1016/j.drugalcdep.2019.02.035
- O’Brien D, Long J, Quigley J, Lee C, McCarthy A, Kavanagh P. Association between electronic cigarette use and tobacco cigarette smoking initiation in adolescents: A systematic review and meta-analysis. BMC Public Health. 2021 Dec; 21(1): 954. DOI: 10.1186/s12889-021-10935-1
- Soneji S, Barrington-Trimis JL, Wills TA, Leventhal AM, Unger JB, Gibson LA, et al. Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults: A systematic review and meta-analysis. JAMA Pediatr. 2017 Aug 1; 171(8): 788. DOI: 10.1001/jamapediatrics.2017.1488
- Benowitz N. The biology of nicotine dependence: From the 1988 Surgeon General’s Report to the present and into the future. Nicotine Tob Res. 1999; 1(1): 159–63. DOI: 10.1080/14622299050012001
- Centers for Disease Control and Prevention. Smoking Cessation: Fast Facts. Centers for Disease Control and Prevention; 2022.
https://www.cdc.gov/tobacco/data_statistics/fact_sheets/cessation/smoking-cessation-fast-facts/index.html (accessed 17 Feb 2023). - Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T. Nicotine replacement therapy versus control for smoking cessation. Cochrane Tobacco Addiction Group, editor. Cochrane Database Syst Rev. 2018 May 31; 2019(1).
http://doi.wiley.com/10.1002/14651858.CD000146.pub5 (accessed 11 Apr 2023). DOI: 10.1002/14651858.CD000146.pub5 - Kumbhalwar A, Hegde S, Kakodkar P, Mehta V, Gupte H, Jadhav S. Effectiveness of behavioral counseling in smokeless tobacco cessation among adult users reporting to a dental hospital in Pune: A randomized controlled trial. Cureus. 2022 Apr; 14(4):
e24041 . DOI: 10.7759/cureus.24041 - Mushtaq N, Beebe LA. Evaluating the psychometric properties of the Severson 7-Item Smokeless Tobacco Dependence Scale (SSTDS). Nicotine Tob Res Off J Soc Res Nicotine Tob. 2021 Jun 8; 23(7): 1224–9. DOI: 10.1093/ntr/ntaa269
- Henningfield JE, Fant RV, Tomar SL. Smokeless tobacco: An addicting drug. Adv Dent Res. 1997 Sep; 11(3): 330–5. DOI: 10.1177/08959374970110030401
- Aboaziza E, Eissenberg T. Waterpipe tobacco smoking: What is the evidence that it supports nicotine/tobacco dependence? Tob Control. 2015 Mar; 24 (Suppl 1): i44–53. DOI: 10.1136/tobaccocontrol-2014-051910
- Picciotto MR, Zoli M, Rimondini R, Léna C, Marubio LM, Pich EM, et al. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature. 1998 Jan; 391(6663): 173–7. DOI: 10.1038/34413
- McGranahan TM, Patzlaff NE, Grady SR, Heinemann SF, Booker TK. Alpha4Beta2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci. 2011 Jul 27; 31(30): 10891–902. DOI: 10.1523/JNEUROSCI.0937-11.2011
- Bombardi C, Delicata F, Tagliavia C, Pierucci M, Deidda G, Casarrubea M, et al. Acute and chronic nicotine exposures differentially affect central serotonin 2A receptor function: Focus on the lateral habenula. Int J Mol Sci. 2020 Mar 9; 21(5): 1873. DOI: 10.3390/ijms21051873
- Quattrocki E, Baird A, Yurgelun-Todd D. Biological aspects of the link between smoking and depression. Harv Rev Psychiatry. 2000 Sep; 8(3): 99–110. DOI: 10.1080/hrp_8.3.99
- Sanouri Ursprung WW, Savageau JA, DiFranza JR. What is the significance of experiencing relaxation in response to the first use of nicotine? Addict Res Theory. 2011 Feb; 19(1): 14–21. DOI: 10.3109/16066359.2010.507892
- Pomerleau OF, Pomerleau CS, Namenek RJ. Early experiences with tobacco among women smokers, ex-smokers, and never-smokers. Addiction. 1998 Apr; 93(4): 595–9. DOI: 10.1046/j.1360-0443.1998.93459515.x
- Chen X, Stacy A, Zheng H, Shan J, Spruijt-Metz D, Unger J, et al. Sensations from initial exposure to nicotine predicting adolescent smoking in China: A potential measure of vulnerability to nicotine. Nicotine Tob Res. 2003 Jul 1; 5(4): 455–63. DOI: 10.1016/0376-8716(93)90030-T
- Henningfield JE, Stapleton JM, Benowitz NL, Grayson RF, London ED. Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend. 1993 Jun; 33(1): 23–9. DOI: 10.1016/0376-8716(93)90030-T
- Allain F, Minogianis EA, Roberts DCS, Samaha AN. How fast and how often: The pharmacokinetics of drug use are decisive in addiction. Neurosci Biobehav Rev. 2015 Sep; 56: 166–79. DOI: 10.1016/j.neubiorev.2015.06.012
- Buchhalter AR, Acosta MC, Evans SE, Breland AB, Eissenberg T. Tobacco abstinence symptom suppression: The role played by the smoking-related stimuli that are delivered by denicotinized cigarettes. Addict Abingdon Engl. 2005 Apr; 100(4): 550–9. DOI: 10.1111/j.1360-0443.2005.01030.x
- Balfour DJK. Neural mechanisms underlying nicotine dependence. Addiction. 1994 Nov; 89(11): 1419–23. DOI: 10.1111/j.1360-0443.1994.tb03738.x
- Piasecki TM, Jorenby DE, Smith SS, Fiore MC, Baker TB. Smoking withdrawal dynamics: I. Abstinence distress in lapsers and abstainers. J Abnorm Psychol. 2003 Feb; 112(1): 3–13. DOI: 10.1037//0021-843X.112.1.3
- Eissenberg T. Measuring the emergence of tobacco dependence: The contribution of negative reinforcement models. Addict Abingdon Engl. 2004 Jun; 99(Suppl 1): 5–29. DOI: 10.1111/j.1360-0443.2004.00735.x
- Gorman D, May A. Ryanair passenger ‘caught vaping’ on flight to Ibiza bundled off plane by police. Mirror; 2022.
https://www.mirror.co.uk/news/uk-news/ryanair-passenger-caught-vaping-flight-27217923 (accessed 21 Apr 2023). - Kedia S, Ahuja N, Hammal F, Asfar T, Eissenberg T, Maziak W, et al. ‘Waterpipe is like a wife’: Qualitative assessment of perspectives on waterpipe smoking dependence. Addict Health. 2022 Oct 29; 14(4): 268–78. DOI: 10.34172/ahj.2022.1377
- Devi R, Barman D, Sinha S, Hazarika S, Das S. Nicotine replacement therapy: A friend or foe. J Fam Med Prim Care. 2020; 9(6): 2615. DOI: 10.4103/jfmpc.jfmpc_313_20
- World Health Organization.
WHO Model List of Essential Medicines. 22nd List . Geneva: World Health Organization; 2021. Available from:https://list.essentialmeds.org/ (accessed 10 Apr 2023). DOI: 10.1530/ey.19.13.1 - United States Public Health Service Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health.
Smoking cessation: A report of the Surgeon General . Washington, DC: US Department of Health and Human Services; 2020. (Publications and Reports of the Surgeon General).http://www.ncbi.nlm.nih.gov/books/NBK555591/ (accessed 11 Apr 2023). - Ebbert JO, Elrashidi MY, Stead LF. Interventions for smokeless tobacco use cessation. Cochrane Tobacco Addiction Group, editor. Cochrane Database Syst Rev. 2015 Oct 26;
https://doi.wiley.com/10.1002/14651858.CD004306.pub5 (accessed 11 Apr 2023). DOI: 10.1002/14651858.CD004306.pub5 - Canadian Agency for Drugs and Technologies in Health.
Nicotine replacement therapy for smoking cessation or reduction: A review of the clinical evidence . Ottawa, ON: Canadian Agency for Drugs and Technologies in Health; 2014. (CADTH Rapid Response Reports).http://www.ncbi.nlm.nih.gov/books/NBK195714/ (accessed 11 Apr 2023). - Rigotti NA. Pharmacotherapy for smoking cessation in adults. UpToDate; 2023.
https://www.uptodate.com/contents/pharmacotherapy-for-smoking-cessation-in-adults (accessed 17 Feb 2023). - Lindson N, Chepkin SC, Ye W, Fanshawe TR, Bullen C, Hartmann-Boyce J. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Tobacco Addiction Group, editor. Cochrane Database Syst Rev. 2019 Apr 18; 2019(4).
http://doi.wiley.com/10.1002/14651858.CD013308 (accessed 11 Apr 2023). DOI: 10.1002/14651858.CD013308 - Dollerup J, Vestbo J, Murray-Thomas T, Kaplan A, Martin RJ, Pizzichini E, et al. Cardiovascular risks in smokers treated with nicotine replacement therapy: A historical cohort study. Clin Epidemiol. 2017 Apr; 9: 231–43. DOI: 10.1016/S0735-1097(97)00079-X
- Benowitz NL, Gourlay SG. Cardiovascular toxicity of nicotine: Implications for nicotine replacement therapy. J Am Coll Cardiol. 1997 Jun; 29(7): 1422–31. DOI: 10.1016/S0735-1097(97)00079-X
- Pack QR, Priya A, Lagu TC, Pekow PS, Atreya A, Rigotti NA, et al. Short-term safety of nicotine replacement in smokers hospitalized with coronary heart disease. J Am Heart Assoc. 2018 Sep 18; 7(18):
e009424 . DOI: 10.1161/JAHA.118.009424 - Hanewinkel R, Niederberger K, Pedersen A, Unger JB, Galimov A. E-cigarettes and nicotine abstinence: A meta-analysis of randomised controlled trials. Eur Respir Rev. 2022 Mar 31; 31(163): 210215. DOI: 10.1183/16000617.0215-2021
- Hyland A, Rezaishiraz H, Giovino G, Bauer J, Michael Cummings K. Over-the-counter availability of nicotine replacement therapy and smoking cessation. Nicotine Tob Res. 2005 Aug 1; 7(4): 547–55. DOI: 10.1080/14622200500185975
- Yingst JM, Hrabovsky S, Hobkirk A, Trushin N, Richie JP, Foulds J. Nicotine absorption profile among regular users of a pod-based electronic nicotine delivery system. JAMA Netw Open. 2019 Nov 15; 2(11):
e1915494 . DOI: 10.1001/jamanetworkopen.2019.15494 - Hughes JR. Dependence potential and abuse liability of nicotine replacement therapies. Biomed Pharmacother. 1989 Jan; 43(1): 11–7. DOI: 10.1016/0753-3322(89)90185-6
- World Health Organization. Summary results of the global youth tobacco survey in selected countries of the WHO European Region. World Health Organization Regional Office for Europe; 2020.
https://apps.who.int/iris/bitstream/handle/10665/336752/WHO-EURO-2020-1513-41263-56157-eng.pdf?sequence=1&isAllowed=y (accessed 21 Apr 2023). - Ferkol TW, Farber HJ, La Grutta S, Leone FT, Marshall HM, Neptune E, et al. Electronic cigarette use in youths: A position statement of the Forum of International Respiratory Societies. Eur Respir J. 2018 May; 51(5): 1800278. DOI: 10.1183/13993003.00278-2018
- Wang TW, Neff LJ, Park-Lee E, Ren C, Cullen KA, King BA. E-cigarette use among middle and high school students — United States, 2020. MMWR Morb Mortal Wkly Rep. 2020 Sep 18; 69(37): 1310–2. DOI: 10.15585/mmwr.mm6937e1
- Lauterstein D, Hoshino R, Gordon T, Watkins BX, Weitzman M, Zelikoff J. The changing face of tobacco use among United States youth. Curr Drug Abuse Rev. 2014 Nov 17; 7(1): 29–43. DOI: 10.2174/1874473707666141015220110
- Conference of the Parties to the WHO Framework Convention on Tobacco Control. Novel and emerging tobacco products – Decisions FCTC/COP8(22). Framework Convention on Tobacco Control; 2018.
https://fctc.who.int/publications/m/item/fctc-cop8(22)-novel-and-emerging-tobacco-products (accessed 21 Apr 2023). - WHO Framework Convention on Tobacco Control. Guidelines for implementation of Article 14. WHO FCTC; 2013.
https://fctc.who.int/publications/m/item/guidelines-for-implementation-of-article-14 (accessed 17 Feb 2023). - Donny EC, White CM. A review of the evidence on cigarettes with reduced addictiveness potential. Int J Drug Policy. 2022 Jan; 99: 103436. DOI: 10.1016/j.drugpo.2021.103436
- White CM, Pickworth WB, Sved AF, Donny EC. Using product standards to render the most harmful tobacco products minimally addictive: Maximum nicotine level, non-nicotine constituents, and scope. Nicotine Tob Res. 2019 Dec 23; 21(Supplement_1): S13–5. DOI: 10.1093/ntr/ntz121
- Higgins ST, Heil SH, Sigmon SC, Tidey JW, Gaalema DE, Hughes JR, et al. Addiction potential of cigarettes with reduced nicotine content in populations with psychiatric disorders and other vulnerabilities to tobacco addiction. JAMA Psychiatry. 2017 Oct 1; 74(10): 1056. DOI: 10.1001/jamapsychiatry.2017.2355
- Omaiye EE, McWhirter KJ, Luo W, Pankow JF, Talbot P. High-nicotine electronic cigarette products: Toxicity of JUUL fluids and aerosols correlates strongly with nicotine and some flavor chemical concentrations. Chem Res Toxicol. 2019 Jun 17; 32(6): 1058–69. DOI: 10.1021/acs.chemrestox.8b00381
- Cheng T. Chemical evaluation of electronic cigarettes. Tob Control. 2014 May; 23(suppl 2): ii11–7. DOI: 10.1136/tobaccocontrol-2013-051482
- European Heart Network. Electronic cigarettes and cardiovascular disease – An update from the European Heart Network. European Heart Network; 2019.
http://www.ehnheart.org/images/EHN_e-cigarettes_final_final.pdf (accessed 30 Nov 2020). - Menakuru S, Inzamam Ali M. Beliefs and reality of e-cigarette smoking. BMJ Case Rep. 2018 Oct 2; bcr-2018-225683. DOI: 10.1136/bcr-2018-225683
- Berry KM, Fetterman JL, Benjamin EJ, Bhatnagar A, Barrington-Trimis JL, Leventhal AM, et al. Association of electronic cigarette use with subsequent initiation of tobacco cigarettes in US youths. JAMA Netw Open. 2019 Feb 1; 2(2):
e187794 . DOI: 10.1001/jamanetworkopen.2018.7794 - Chivers E, Janka M, Franklin P, Mullins B, Larcombe A. Nicotine and other potentially harmful compounds in “nicotine-free” e-cigarette liquids in Australia. Med J Aust. 2019 Feb; 210(3): 127–8. DOI: 10.2174/1570159X15666171016164430
- DeVito EE, Krishnan-Sarin S. E-cigarettes: Impact of e-liquid components and device characteristics on nicotine exposure. Curr Neuropharmacol. 2018 May 1; 16(4): 438–59. DOI: 10.1136/tobaccocontrol-2019-055499
- Eissenberg T, Soule E, Shihadeh A, CSTP Nicotine Flux Work Group. ‘Open-system’ electronic cigarettes cannot be regulated effectively. Tob Control. 2021 Mar; 30(2): 234–5. DOI: 10.1136/tobaccocontrol-2019-055499
DOI: https://doi.org/10.5334/gh.1292 | Journal eISSN: 2211-8179
Language: English
Submitted on: Nov 17, 2023
Accepted on: Dec 28, 2023
Published on: Jan 31, 2024
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
© 2024 E. Ulysses Dorotheo, Monika Arora, Amitava Banerjee, Eduardo Bianco, Nuan Ping Cheah, Regina Dalmau, Thomas Eissenberg, Koji Hasegawa, Pamela Naidoo, Noreen T. Nazir, L. Kristin Newby, Nour Obeidat, Andrii Skipalskyi, Janina Stępińska, Jeffrey Willett, Yunshu Wang, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.