Figure 1
Differential and common shared genetic basis between BP and vascular calcium. (A) Genetic correlation between SBP and vascular calcium using LDSC. (B) Two-sample Mendelian randomization analyses between BP and vascular calcium. (C) Local genetic correlation between SBP and vascular calcium. The Manhattan plot showed the estimates of local genetic correlation and local genetic covariance between LTL and MDD, and local SNP heritability of LTL and MDD, respectively. Red and blue bars in ‘local genetic correlation’ and ‘local genetic covariance’ represent significant regions which shared SNP heritability, after multiple adjustments (P < 5E-08 in both local SNP heritability test, and P < 0.05/1703 in local genetic covariance test). Black bars showed nominal significant (P < 0.05). (D) Pathway enrichment analysis of shared SNPs of SBP and vascular calcium. (E) Significant pleiotropic SNPs identified by cross-trait meta-analyses and ρ-HESS.