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Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions Cover

Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions

Open Access
|Jun 2025

Figures & Tables

Figure 1

Number of publications on Mendelian randomisation studies until 2024. The data depicted in this figure have been extracted from PubMed on February 24th 2025 using the search terms “Mendelian randomization” OR “Mendelian randomisation”. Publications from 2025 have been excluded.

Table 1

Opportunities, challenges, and future directions of Mendelian randomisation.

MENDELIAN RANDOMISATION
Opportunities
  • Causal relationships between exposures and outcomes

  • Drug-target prioritisation

Challenges
  • Validity of the assumptions

  • Selection bias

  • Comparison to randomised controlled trials

  • Mendelian randomisation within subgroups

Future perspectives
  • Integration of omics data

  • Availability of subgroup-specific genetic data

  • A subgroup-specific approach in multi-omics data integration

Figure 2

Directed acyclic graphs on selection bias in Mendelian randomisation analyses. Directed acyclic graphs where G represents the instrumental variable, X the exposure, U the confounder, Y the outcome and where selection (S) leads to selection bias if it is dependent on levels of the exposure (panel A) or outcome (panel B).

DOI: https://doi.org/10.5334/gh.1438 | Journal eISSN: 2211-8179
Language: English
Submitted on: May 12, 2025
Accepted on: May 27, 2025
Published on: Jun 17, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Sophie C. de Ruiter, Lena Tschiderer, Diederick E. Grobbee, Peter Willeit, Hester M. den Ruijter, A. Floriaan Schmidt, Sanne A. E. Peters, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.