Skip to main content
Have a personal or library account? Click to login
Prevalence, Clinical Characteristics and Prognosis of Vascular Disease in Valvular Heart Surgery: A Multi-Centre Study Cover

Prevalence, Clinical Characteristics and Prognosis of Vascular Disease in Valvular Heart Surgery: A Multi-Centre Study

Open Access
|Aug 2025

References

  1. United Nations Department of Economic and Social Affairs, Population Division. World Population Prospects 2022: Summary of Results. UN DESA/POP/2022/TR/NO.3; 2022.
  2. Mensah GA, Fuster V, Murray CJL, Roth GA; Global Burden of Cardiovascular Diseases and Risks Collaborators. Global burden of cardiovascular diseases and risks, 1990–2022. Journal of the American College of Cardiology. 2023;82(25):23502473. DOI: 10.1016/j.jacc.2023.11.007
  3. Iung B, Delgado V, Rosenhek R, Price S, Prendergast B, Wendler O, et al. Contemporary presentation and management of valvular heart disease: The EURObservational Research Programme Valvular Heart Disease II Survey. Circulation. 2019;140(14):11561169. DOI: 10.1161/CIRCULATIONAHA.119.041080
  4. Santangelo G, Bursi F, Faggiano A, Moscardelli S, Simeoli PS, Guazzi M, et al. The global burden of valvular heart disease: From clinical epidemiology to management. Journal of Clinical Medicine. 2023;12(6):2178. DOI: 10.3390/jcm12062178
  5. Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021;143(5):e72e227. DOI: 10.1161/CIR.0000000000000923
  6. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(23):e521e643. DOI: 10.1161/CIR.0000000000000031
  7. Coffey S, Roberts-Thomson R, Brown A, Carapetis J, Chen M, Enriquez-Sarano M, et al. Global epidemiology of valvular heart disease. Nature Reviews Cardiology. 2021;18(12):853864. DOI: 10.1038/s41569-021-00570-z
  8. Enriquez-Sarano M, Schaff HV, Orszulak TA, Bailey KR, Tajik AJ, Frye RL. Congestive heart failure after surgical correction of mitral regurgitation. A long-term study. Circulation. 1995;92:24962503. DOI: 10.1161/01.CIR.92.9.2496
  9. Bhatt DL, Eagle KA, Ohman EM, Hirsch AT, Goto S, Mahoney EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010;304(12):13501357. DOI: 10.1001/jama.2010.1322
  10. Gutierrez JA, Mulder H, Jones WS, Rockhold FW, Baumgartner I, Berger JS, et al. Polyvascular disease and risk of major adverse cardiovascular events in peripheral artery disease: A secondary analysis of the EUCLID trial. JAMA Network Open. 2018;1(7):e185239. DOI: 10.1001/jamanetworkopen.2018.5239
  11. Wang TK, Choi DH, Stewart R, Gamble G, Haydock D, Ruygrok P. Comparison of four contemporary risk models at predicting mortality after aortic valve replacement. The Journal of Thoracic and Cardiovascular Surgery. 2015;149(2):443448. DOI: 10.1016/j.jtcvs.2014.04.032
  12. Tse YK, Chandramouli C, Li HL, Yu SY, Wu MZ, Ren QW, et al. Concomitant hepatorenal dysfunction and malnutrition in valvular heart surgery: Long-term prognostic implications for death and heart failure. Journal of the American Heart Association. 2022;11(10):e024060. DOI: 10.1161/JAHA.121.024060
  13. Yiu KH, Wong A, Pu L, Chiang MF, Sit KY, Chan D, et al. Prognostic value of preoperative right ventricular geometry and tricuspid valve tethering area in patients undergoing tricuspid annuloplasty. Circulation. 2014;129(1):8792. DOI: 10.1161/CIRCULATIONAHA.113.003811
  14. Roques F, Michel P, Goldstone AR, Nashef SA. The logistic EuroSCORE. European Heart Journal. 2003;24(9):881882. DOI: 10.1016/S0195-668X(02)00799-6
  15. Peterson BE, Bhatt DL, Ballantyne CM, de Lemos JA, Rosenson RS, Kosiborod MN, et al. Intensity of lipid-lowering therapy among patients with polyvascular disease. JAMA Network Open. 2023;6(3):e234709. DOI: 10.1001/jamanetworkopen.2023.4709
  16. Khan MS, Anker SD, Filippatos G, Ferreira JP, Pocock SJ, Januzzi JL, et al. Vascular disease burden, outcomes and benefits with empagliflozin in heart failure: Insights from the EMPEROR-reduced trial. Journal of Cardiac Failure. 2023;29(10):13451354. DOI: 10.1016/j.cardfail.2023.06.024
  17. Brunner S, Covtun O, Moccetti F, Loretz L, Bossard M, Attinger-Toller A, et al. Long-term outcomes after transcatheter aortic valve implantation in patients with chronic inflammatory disease. Journal of the American Heart Association. 2024;13(5):e032250. DOI: 10.1161/JAHA.123.032250
  18. Akyol O, Yang CY, Woodside DG, Chiang HH, Chen CH, Gotto AM. Comparative analysis of atherogenic lipoproteins L5 and Lp(a) in atherosclerotic cardiovascular disease. Current Atherosclerosis Reports. 2024. DOI: 10.1007/s11883-024-01209-3
  19. Nissen SE, Wolski K, Watts GF, Koren MJ, Fok H, Nicholls SJ, et al. Single ascending and multiple-dose trial of Zerlasiran, a short interfering RNA targeting lipoprotein(a): A randomized clinical trial. JAMA. 2024;331(18):15341543. DOI: 10.1001/jama.2024.4504
  20. Ballester-Servera C, Cañes L, Alonso J, Puertas-Umbert L, Vázquez-Sufuentes P, Taurón M, et al. Upregulation of NOR-1 in calcified human vascular tissues: Impact on osteogenic differentiation and calcification. Translational Research. 2024;264:114. DOI: 10.1016/j.trsl.2023.09.004
  21. Bansal K, Soni A, Shah M, Kosinski AS, Gilani F, Khera S, et al. Association between polyvascular disease and transcatheter aortic valve replacement outcomes: Insights from the STS/ACC TVT registry. Circulation: Cardiovascular Interventions. 2023;16(12):e013578. DOI: 10.1161/CIRCINTERVENTIONS.123.013578
  22. Martin SS, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, et al. 2024 Heart disease and stroke statistics: A report of US and global data from the American Heart Association. Circulation. 2024;149(8):e347e913. DOI: 10.1161/CIR.0000000000001209
  23. Beach JM, Mihaljevic T, Svensson LG, Rajeswaran J, Marwick T, Griffin B, et al. Coronary artery disease and outcomes of aortic valve replacement for severe aortic stenosis. Journal of the American College of Cardiology. 2013;61(8):837848. DOI: 10.1016/j.jacc.2012.10.049
  24. Thalji NM, Suri RM, Daly RC, Greason KL, Dearani JA, Stulak JM, et al. The prognostic impact of concomitant coronary artery bypass grafting during aortic valve surgery: Implications for revascularization in the transcatheter era. Journal of Thoracic and Cardiovascular Surgery. 2015;149(2):451460. DOI: 10.1016/j.jtcvs.2014.08.073
  25. Colaiori I, Paolucci L, Mangiacapra F, Barbato E, Ussia GP, Grigioni F, et al. Natural history of coronary atherosclerosis in patients with aortic stenosis undergoing transcatheter aortic valve replacement: The role of quantitative flow ratio. Circulation: Cardiovascular Interventions. 2024: e013705. DOI: 10.1161/CIRCINTERVENTIONS.123.013705
  26. Shahim B, Cohen DJ, Ben-Yehuda O, Redfors B, Kar S, Lim DS, et al. Impact of peripheral artery disease in patients with heart failure undergoing transcatheter mitral valve repair: The COAPT trial. Journal of the American Heart Association. 2023;12(4):e028444. DOI: 10.1161/JAHA.122.028444
  27. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Cheng S, et al. Relations of central hemodynamics and aortic stiffness with left ventricular structure and function: The Framingham heart study. Journal of the American Heart Association. 2016;5(3):e002693. DOI: 10.1161/JAHA.115.002693
  28. Kim HJ, Lee EJ, Jung SH, Lee JW, Kim JS, Kim JB, et al. Cerebral atherosclerosis and early ischemic stroke after left-sided valve replacement surgery. Journal of Thoracic and Cardiovascular Surgery. 2022;163(3):967976.e6. DOI: 10.1016/j.jtcvs.2020.05.002
  29. Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical update: Cardiovascular disease in diabetes mellitus: Atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus - Mechanisms, management, and clinical considerations. Circulation. 2016;133(24):24592502. DOI: 10.1161/CIRCULATIONAHA.116.022194
  30. Yamawaki M, Honda Y, Makino K, Nakano T, Iida Y, Yashima F, et al. Influence of polyvascular disease on clinical outcome in patients undergoing transcatheter aortic valve implantation via transfemoral access. PLoS One. 2021;16(12):e0260385. DOI: 10.1371/journal.pone.0260385
  31. Verma S, Mazer CD, Inzucchi SE, Wanner C, Ofstad AP, Johansen OE, et al. Impact of polyvascular disease with and without co-existent kidney dysfunction on cardiovascular outcomes in diabetes: A post hoc analysis of EMPA-REG OUTCOME. Diabetes, Obesity and Metabolism. 2021;23(5):11731181. DOI: 10.1111/dom.14326
  32. Freedman BL, Berg DD, Scirica BM, Bohula EA, Goodrich EL, Sabatine MS, et al. Epidemiology of heart failure hospitalization in patients with stable atherothrombotic disease: Insights from the TRA 2°P-TIMI 50 trial. Clinical Cardiology. 2022;45(8):831838. DOI: 10.1002/clc.23843
  33. Guida P, Mastro F, Scrascia G, Whitlock R, Paparella D. Performance of the European System for Cardiac Operative Risk Evaluation II: A meta-analysis of 22 studies involving 145,592 cardiac surgery procedures. Journal of Thoracic and Cardiovascular Surgery. 2014;148(6):304957.e1. DOI: 10.1016/j.jtcvs.2014.07.039
  34. Tse YK, Chandramouli C, Li HL, Yu SY, Wu MZ, Ren QW, et al. Concomitant hepatorenal dysfunction and malnutrition in valvular heart surgery: Long-term prognostic implications for death and heart failure. Journal of the American Heart Association. 2022;11(10):e024060. DOI: 10.1161/JAHA.121.024060
  35. Kuhn EW, Liakopoulos OJ, Stange S, Deppe AC, Slottosch I, Choi YH, et al. Preoperative statin therapy in cardiac surgery: A meta-analysis of 90,000 patients. European Journal of Cardiothoracic Surgery. 2014;45(1):1726;discussion 26. DOI: 10.1093/ejcts/ezt181
  36. Testa C, DI Lorenzo A, Parlato A, D’Ambrosio G, Merolla A, Pacileo M, et al. Exercise for slowing the progression of atherosclerotic process: Effects on inflammatory markers. Panminerva Medica. 2021;63(2):122132. DOI: 10.23736/S0031-0808.21.04266-X
  37. Hegde SM, Gonçalves A, Claggett B, Evenson KR, Cheng S, Shah AM, et al. Cardiac structure and function and leisure-time physical activity in the elderly: The atherosclerosis risk in communities study. European Heart Journal. 2016;37(32):25442551. DOI: 10.1093/eurheartj/ehw121
  38. Cheung BM, Wong YL, Lau CP. Queen Mary Utilization of Antihypertensive Drugs Study: Use of antihypertensive drug classes in the hypertension clinic 1996–2004. British Journal of Clinical Pharmacology. 2005;60(1):9097. DOI: 10.1111/j.1365-2125.2005.02388.x
  39. Li JJ, Liu HH, Wu NQ, Yeo KK, Tan K, Ako J, Krittayaphong R, Tan RS, Aylward PE, Baek SH, Dalal J, Fong AYY, Li YH, O’Brien RC, Lim TSE, Koh SYN, Scherer DJ, Tada H, Kang V, Butters J, Nicholls SJ. Statin intolerance: An updated, narrative review mainly focusing on muscle adverse effects. Expert Opinion on Drug Metabolism & Toxicology. 2020;16(9):837851. DOI: 10.1080/17425255.2020.1802426
DOI: https://doi.org/10.5334/gh.1462 | Journal eISSN: 2211-8179
Language: English
Submitted on: May 16, 2025
Accepted on: Aug 10, 2025
Published on: Aug 28, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Ching-Yan Zhu, Jing-Nan Zhang, Yi-Kei Tse, Qing-Wen Ren, Jia-Yi Huang, Si-Yeung Yu, Ran Guo, Wen-Li Gu, Daniel Tai-Leung Chan, Gregory YH Lip, Kai-Hang Yiu, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.