Figure 1
Diagram for atrial fibrillation diagnosis in the ECG database.
Table 1
Prevalence of atrial fibrillation according to age distribution and sex.
| Age (years) | N | Prevalence n; (%) | ||
|---|---|---|---|---|
| Male | Female | Male | Female | |
| 17–30 | 89,999 | 126,966 | 150 (0.17) | 87 (0.07) |
| 31–40 | 82,116 | 140,047 | 280 (0.34) | 206 (0.15) |
| 41–50 | 106,986 | 181,680 | 554 (0.52) | 405 (0.22) |
| 51–60 | 128,794 | 192,175 | 1,344 (1.04) | 954 (0.50) |
| 61–70 | 113,793 | 150,517 | 2,690 (2.36) | 1,978 (1.31) |
| 71–80 | 74,344 | 96,774 | 3,698 (4.97) | 3,257 (3.37) |
| >80 | 31,010 | 43,220 | 2,610 (8.42) | 2,569 (5.94) |
| Total | 627,042 | 931,379 | 11,326 (1.81) | 9,456 (1.02) |
Table 2
Baseline data by prevalence of atrial fibrillation.
| Variable | Patients with AF (n = 20,782) | Patients without AF (n = 1,445,584) | Age- and Sex-adjusted OR (95% CI) | Multivariable-adjusted* OR (95% CI) |
|---|---|---|---|---|
| Age (years) | 71.1 ± 13.7 | 51.6 ± 17.6 | 1.08 (1.08–1.08) | |
| Male sex | 11,326 (54.5) | 615,716 (40.0) | 1.79 (1.74–1.84) | |
| Current smoking | 1,368 (6.6) | 107,447 (7.0) | 0.94 (0.89–0.99) | 0.94 (0.89–0.99) |
| Hypertension | 10,288 (49.5) | 482,353 (31.4) | 2.14 (2.09–2.20) | 1.31 (1.27–1.34) |
| Diabetes | 1,769 (8.5) | 99,701 (6.5) | 1.34 (1.28–1.41) | 0.99 (0.95–1.05) |
| Dyslipidemia | 1,115 (5.4) | 59,475 (3.9) | 1.41 (1.33–1.50) | 1.09 (1.03–1.16) |
| Chagas disease | 1,479 (7.1) | 33,111 (2.2) | 3.48 (3.30–3.67) | 3.08 (2.91–3.25) |
| MI | 377 (1.8) | 11,227 (0.7) | 2.51 (2.26–2.79) | 1.74 (1.56–1.93) |
| COPD | 338 (1.6) | 10,928 (0.7) | 2.31 (2.07–2.58) | 1.48 (1.33–1.66) |
[i] Data are presented as mean (±SD) or number (%).
OR, odds ratio; CI, confidence interval; COPD, chronic obstructive pulmonary disease; MI, myocardial infarction *multivariable models adjusted for variables in the table.
Table 3
Event rates in patients with atrial fibrillation.
| Outcome | N | Events | % | Event rate (per 100 person-years) | 95%CI |
|---|---|---|---|---|---|
| All-cause death | 20,782 | 3,701 | 17.81 | 1.78 | (1.72–1.84) |
| Cardiovascular death | 20,782 | 398 | 1.91 | 1.89 | (1.73–2.13) |
Figure 2
Kaplan-Meier survival curves for atrial fibrillation according to sex.
Table 4
Adjusted Hazards of Atrial Fibrillation for Mortality.
| Type of event | HR (CI 95%) | p-value | ||
|---|---|---|---|---|
| All patients+ | Male* | Female* | ||
| Death for all causes | 2.10 (2.03–2.17) | 1.83 (1.74–1.91) | 2.59 (2.47–2.73) | <0.001 |
| Cardiovascular death | 2.06 (1.86–2.29) | 1.71 (1.62–1.80) | 2.62 (2.24–3.06) | <0.001 |
[i] HR, hazard ratio; CI, confidence interval.
+ adjusted for age, sex and comorbidities.
* adjusted for age and comorbidities.