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Cardiovascular Findings in Severe Malaria: A Review Cover

Cardiovascular Findings in Severe Malaria: A Review

Open Access
|Nov 2020

References

  1. World Malaria Report 2018. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO.
  2. Sprague HB. Effects of malaria on the heart. Air Surg Bull. 1945; 2: 413. PubMed. PMID: 21065366.
  3. Franzen D, Curtius JM, Heitz W, Höpp HW, Diehl V, Hilger HH. Cardiac involvement during and after malaria. Clin Investig. August 1992; 70(8): 6703. PubMed PMID: 1392443. DOI: 10.1007/BF00180283
  4. Bhat S, Kumar M, Alva J. Malaria and the conducting system of the heart. BMJ Case Rep. 29 January 2013; 2013. pii: bcr2012007462. PubMed PMID: 23365175; PubMed Central PMCID: PMC3603845. DOI: 10.1136/bcr-2012-007462
  5. Bhat S, Alva J, Muralidhara K, Fahad S. Malaria and the heart. BMJ Case Rep. 27 November 2012; 2012. pii: bcr2012007275. PubMed PMID: 23188857; PubMed Central PMCID: PMC4544263. DOI: 10.1136/bcr-2012-007275
  6. Ehrhardt S, Mockenhaupt FP, Anemana SD, Otchwemah RN, Wichmann D, Cramer JP, et al. High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria. Microbes Infect, 7: 12041210. DOI: 10.1016/j.micinf.2005.04.007
  7. Etyang AO, Kapesa S, Odipo E, Bauni E, Kyobutungi C, Abdalla M, et al. Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study. J Am Heart Assoc. 19 March 2019; 8(6): e011771. PubMed PMID: 30879408; PubMed Central PMCID: PMC6475058. DOI: 10.1161/JAHA.118.011771
  8. Raza A, Ghanchi NK, Sarwar Zubairi Ab, Raheem A, Nizami S, Beg MA. Tumor necrosis factor-α, interleukin-10, intercellular and vascular adhesion molecules are possible biomarkers of disease severity in complicated Plasmodium vivax isolates from Pakistan. PLoS One. 2013; 8: e81363. DOI: 10.1371/journal.pone.0081363
  9. Pongponratn E, Riganti M, Punpoowong B, Aikawa M. Microvascular sequestration of parasitized erythrocytes in human falciparum malaria: A pathological study. Am J Trop Med Hyg. 1991; 44(2): 168175. 1991.44.168. DOI: 10.4269/ajtmh.1991.44.168
  10. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 30 June 2011; 364(26): 2483 95. 1101549. Epub 26 May 2011. PubMed PMID: 21615299. DOI: 10.1056/NEJMoa1101549
  11. Maitland K, George EC, Evans JA, et al. Exploring mechanisms of excess mortality with early fluid resuscitation: Insights from the FEAST trial. BMC Med. 2013. DOI: 10.1186/1741-7015-11-68
  12. Moher D, Liberati A, Tetzlaff K, et al. Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. J clin epidemiol. 2009; 62: 100612. DOI: 10.1016/j.jclinepi.2009.06.005
  13. World Health Organization. Severe malaria. Trop Med Int Health. 2014; 19 Suppl 1: 7131. DOI: 10.1111/tmi.12313_2
  14. Charoenpan P, Indraprasit S, Kiatboonsri S, Suvachittanont O, Tanomsup S. Pulmonary edema in severe falciparum malaria. Hemodynamic study and clinicophysiologic correlation. Chest. 1990; 97(5): 11901197. DOI: 10.1378/chest.97.5.1190
  15. Beards SC, Joynt GM, Lipman J. Haemodynamic and oxygen transport response during exchange transfusion for severe falciparum malaria. Postgrad Med J. November 1994; 70(829): 8014. PubMed PMID: 7824413; PubMed Central PMCID: PMC2397837. DOI: 10.1136/pgmj.70.829.801
  16. Bruneel F, Gachot B, Timsit JF, Wolff M, Bédos JP, Régnier B, Vachon F. Shock complicating severe falciparum malaria in European adults. Intensive Care Med. June 1997; 23(6): 698701. PubMed PMID: 9255652. DOI: 10.1007/s001340050396
  17. Lagudis S, Camargo LF, Meyer EC, Fernandes CJ, Akamine N, Knobel E. Hyperdynamic shock in falciparum malaria. Intensive Care Med. January 2000; 26(1): 142. PubMed PMID: 10663298. DOI: 10.1007/s001340050029
  18. Saïssy JM, Seck M, Rouvin B, Diatta B, Ndiaye M, Angel G. Hemodynamic aspects and oxygenation variables in severe malaria of adults in Africa. Intensive Care Med. October 2000; 26(10): 144953. PubMed PMID: 11126255. DOI: 10.1007/s001340000651
  19. Mohsen AH, Green ST, West JN, McKendrick MW. Myocarditis associated with Plasmodium falciparum malaria: A case report and a review of the literature. J Travel Med. 2001; 8(4): 219220. DOI: 10.2310/7060.2001.22133
  20. Janka JJ, Koita OA, Traoré B, Traoré JM, Mzayek F, Sachdev V, et al. Increased pulmonary pressures and myocardial wall stress in children with severe malaria. J Infect Dis. 1 September 2010; 202(5): 791800. PubMed PMID: 20662718; PubMed Central PMCID: PMC3206728. DOI: 10.1086/655225
  21. Yacoub S, Lang HJ, Shebbe M, Timbwa M, Ohuma E, Tulloh R, Maitland K. Cardiac function and hemodynamics in Kenyan children with severe malaria. Crit Care Med. March 2010; 38(3): 9405. PubMed PMID: 20068463. DOI: 10.1097/CCM.0b013e3181cd114a
  22. Hanson J, Lam SW, Mohanty S, Alam S, Hasan MM, Lee SJ, et al. Central venous catheter use in severe malaria: Time to reconsider the World Health Organization guidelines? Malar J. 14 November 2011; 10: 342. PubMed PMID: 22082224; PubMed Central PMCID: PMC3228715. DOI: 10.1186/1475-2875-10-342
  23. Herr J, Mehrfar P, Schmiedel S, Wichmann D, Brattig NW, Burchard GD, Cramer JP. Reduced cardiac output in imported Plasmodium falciparum malaria. Malar J. 9 June 2011; 10: 160. PubMed PMID: 21658247; PubMed Central PMCID: PMC3130699. DOI: 10.1186/1475-2875-10-160
  24. Mocumbi AO, Songane M, Salomão C, Ulibarri R, Ferreira MB, Yacoub MH. Lack of evidence of myocardial damage in children with Plasmodium falciparum severe and complicated malaria from an endemic area for endomyocardial fibrosis. J Trop Pediatr. August 2011; 57(4): 3124. Epub 30 November 2009. PubMed PMID: 19948781. DOI: 10.1093/tropej/fmp114
  25. Murphy S, Cserti-Gazdewich C, Dhabangi A, Musoke C, Nabukeera-Barungi N, Price D, et al. Ultrasound findings in Plasmodium falciparum malaria: A pilot study. Pediatr Crit Care Med. March 2011; 12(2): e58–63. PubMed PMID: 20581730. DOI: 10.1097/PCC.0b013e3181e89992
  26. Nguyen HP, Hanson J, Bethell D, Nguyen TH, Tran TH, Ly VC, Pham PL, et al. A retrospective analysis of the haemodynamic and metabolic effects of fluid resuscitation in Vietnamese adults with severe falciparum malaria. PLoS One. 2011; 6(10): e25523. Epub 11 October 2011. PubMed PMID: 22022406; PubMed Central PMCID: PMC3191153. DOI: 10.1371/journal.pone.0025523
  27. Sanklecha M, Mehta N, Bagban H. Varied presentation of complicated falciparum malaria in a family. Indian Pediatr. 2012; 49(5): 413414.
  28. Nguah SB, Feldt T, Hoffmann S, Pelletier D, Ansong D, Sylverken J, Mehrfar P, et al. Cardiac function in Ghanaian children with severe malaria. Intensive Care Med. December 2012; 38(12): 203241. Epub 14 August 2012. PubMed PMID: 22890885. DOI: 10.1007/s00134-012-2676-z
  29. Hanson JP, Lam SW, Mohanty S, Alam S, Pattnaik R, Mahanta KC, et al. Fluid resuscitation of adults with severe falciparum malaria: Effects on acid-base status, renal function, and extravascular lung water. Crit Care Med. April 2013; 41(4): 97281. PubMed PMID: 23324951. DOI: 10.1097/CCM.0b013e31827466d2
  30. Nayak KC, Meena SL, Gupta BK, Kumar S, Pareek V. Cardiovascular involvement in severe vivax and falciparum malaria. J Vector Borne Dis. December 2013; 50(4): 28591. PubMed PMID: 24499851.
  31. Sulaiman H, Ismail MD, Jalalonmuhali M, Atiya N, Ponnampalavanar S. Severe Plasmodium falciparum infection mimicking acute myocardial infarction. Malar J. 2014; 13: 341. Published 30 August 2014. DOI: 10.1186/1475-2875-13-341
  32. Colomba C, Trizzino M, Gioè C, et al. Malaria and the heart: Two rare case reports of ‘Plasmodium falciparum associated’ pericarditis. J Vector Borne Dis. 2017; 54(4): 372374. DOI: 10.4103/0972-9062.225845
  33. Ray HN, Doshi D, Rajan A, Singh AK, Singh SB, Das MK. Cardiovascular involvement in severe malaria: A prospective study in Ranchi, Jharkhand. J Vector Borne Dis. April–June 2017; 54(2): 177182. PubMed PMID: 28748840.
  34. Kotlyar S, Olupot-Olupot P, Nteziyaremye J, Akech SO, Uyoga S, Muhindo R, Moore CL, Maitland K. Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria. Pediatr Crit Care Med. March 2018; 19(3): 179185. PubMed PMID: 29206727; PubMed Central PMCID: PMC5835359. DOI: 10.1097/PCC.0000000000001411
  35. Leopold SJ, Ghose A, Plewes KA, Mazumder S, Pisani L, Kingston HWF, et al. Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study. PLoS ONE. 13(12): e0204832. DOI: 10.1371/journal.pone.0204832
  36. Kingston HW, Ghose A, Rungpradubvong V, Herdman MT, Plewes K, Ishioka H, et al. Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study. Malar J. 25 March 2019; 18(1): 97. PubMed PMID: 30909915; PubMed Central PMCID: PMC6434797. DOI: 10.1186/s12936-019-2733-y
  37. Planche T, Onanga M, Schwenk A, Dzeing A, Borrmann S, Faucher JF, et al. Assessment of volume depletion in children with malaria. PLoS Med. October 2004; 1(1): e18. Epub 19 October 2004. PubMed PMID: 15526044; PubMed Central PMCID: PMC523837. DOI: 10.1371/journal.pmed.0010018
  38. Maitland K, Pamba A, Newton CR, Levin M. Response to volume resuscitation in children with severe malaria. Pediatr Crit Care Med. October 2003; 4(4): 42631. PubMed PMID: 14525636. DOI: 10.1097/01.PCC.0000090293.32810.4E
  39. Kim SA, Kim ES, Rhee MY, Choi SI, Huh HJ, Chae SL. A case of myocarditis associated with Plasmodium vivax malaria. J Travel Med. 2009; 16(2): 138140. DOI: 10.1111/j.1708-8305.2008.00292.x
  40. Ahmad S, Dhar M, Bishnoi S, Shirazi N, Bhat NK. Acute myocarditis in vivax malaria: An extremely rare complication. Trop Doct. 2013; 43(1): 3536. DOI: 10.1177/0049475512473601
  41. White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM. Malaria. Lancet. 22 Febrary 2014; 383(9918): 72335. Epub 15 August 2013. Review. PubMed PMID: 23953767. DOI: 10.1016/S0140-6736(13)60024-0
  42. Maitland K, Levin M, English M, et al. Severe P. falciparum malaria in Kenyan children: Evidence for hypovolaemia. Q J Med. 2003; 96: 427434. DOI: 10.1093/qjmed/hcg077
  43. Gérardin P, Rogier C, Ka AS, Jouvencel P, Diatta B, Imbert P. Outcome of life-threatening malaria in African children requiring endotracheal intubation. Malar J. 30 April 2007; 6: 51. PubMed PMID: 17470294; PubMed Central PMCID:PMC1867821. DOI: 10.1186/1475-2875-6-51
  44. Hanson J, Lee SJ, Mohanty S, Faiz MA, Anstey NM, et al. Rapid Clinical Assessment to Facilitate the Triage of Adults with Falciparum Malaria, a Retrospective Analysis. PLoS ONE. 2014; 9(1): e87020. DOI: 10.1371/journal.pone.0087020
  45. Bruneel F, Tubach F, Corne P, Megarbane B, Mira J-P, et al. Severe Imported Falciparum Malaria: A Cohort Study in 400 Critically Ill Adults. PLoS ONE. 2010; 5(10): e13236. DOI: 10.1371/journal.pone.0013236
  46. Tripathy R, Parida S, Das L, et al. Clinical manifestations and predictors of severe malaria in Indian children. Pediatrics. 2007; 120(3): e454e460. DOI: 10.1542/peds.2006-3171
  47. World Health Organization. Management of Severe Malaria: A practical handbook; Organization WH, ed. Geneva: World Health Organization; 2000, p. 84.
  48. Taylor WR, Canon V, White NJ. Pulmonary manifestations of malaria: recognition and management. Treat Respir Med. 2006; 5: 419428. DOI: 10.2165/00151829-200605060-00007
  49. George EC, Kiguli S, Olupot PO, et al. Mortality risk over time after early fluid resuscitation in African children. Crit Care. 2019; 23(1): 377. Published 27 November 2019. DOI: 10.1186/s13054-019-2619-y
  50. Silversides JA, Fitzgerald E, Manickavasagam US, Lapinsky SE, Nisenbaum R, Hemmings N, et al. Deresuscitation of Patients With Iatrogenic Fluid Overload Is Associated With Reduced Mortality in Critical Illness. Crit Care Med. October 2018; 46(10): 16001607. DOI: 10.1097/CCM.0000000000003276
DOI: https://doi.org/10.5334/gh.789 | Journal eISSN: 2211-8179
Language: English
Submitted on: Mar 19, 2020
Accepted on: Oct 19, 2020
Published on: Nov 4, 2020
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2020 Gavin Wooldridge, Deipanjan Nandi, Yamikani Chimalizeni, Nicole O’Brien, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.