COVID-19: Implications for People with Chagas Disease

Ezequiel José Zaidel; Colin J. Forsyth; Gabriel Novick; Rachel Marcus; Antonio Luiz P. Ribeiro; María-Jesus Pinazo; Carlos A. Morillo; Luis Eduardo Echeverría; Maria Aparecida Shikanai-Yasuda; Pierre Buekens; Pablo Perel; Sheba K. Meymandi; Kate Ralston; Fausto Pinto; Sergio Sosa-Estani

doi:10.5334/gh.891

COVID-19: Implications for People with Chagas Disease

Volume 15 (2020): Issue 1

By: Ezequiel José Zaidel , Colin J. Forsyth , Gabriel Novick , Rachel Marcus , Antonio Luiz P. Ribeiro , María-Jesus Pinazo , Carlos A. Morillo , Luis Eduardo Echeverría , Maria Aparecida Shikanai-Yasuda , Pierre Buekens , Pablo Perel , Sheba K. Meymandi , Kate Ralston , Fausto Pinto and Sergio Sosa-Estani

Open Access

|Oct 2020

Rassi AJr, Rassi A, Marin-Neto JA. Chagas disease. The Lancet. 2010; 375(9723): 1388–402. DOI: 10.1016/S0140-6736(10)60061-X
Open DOI Search in Google Scholar Back to article
Johns Hopkins Coronavirus Resource Center. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) 2020 [updated and accessed September 4, 2020]. Available from: https://coronavirus.jhu.edu/map.html.
Search in Google Scholar Back to article
World Health Organization. Chagas disease in Latin America: An epidemiological update based on 2010 estimates Weekly Epidemiological Record. 2015; 90(6): 33–44.
Search in Google Scholar Back to article
World Health Organization. Fourth WHO Report on Neglected Tropical Diseases. Geneva; 2017.
Search in Google Scholar Back to article
Echeverría LE, Marcus R, Novick G, Sosa-Estani S, Ralston K, Zaidel EJ, et al. WHF IASC Roadmap on Chagas Disease. Global Heart. 2020; 15(1): 26. DOI: 10.5334/gh.484
Open DOI Search in Google Scholar Back to article
Ribeiro AL, Nunes MP, Teixeira MM, Rocha MOC. Diagnosis and management of Chagas disease and cardiomyopathy. Nature Reviews Cardiology. 2012; 9(10): 576–589. DOI: 10.1038/nrcardio.2012.109
Open DOI Search in Google Scholar Back to article
Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, et al. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. European Journal of Clinical Investigation. 2009; 39(7): 618–625. DOI: 10.1111/j.1365-2362.2009.02153.x
Open DOI Search in Google Scholar Back to article
Chen L, Li X, Chen M, Feng Y, Xiong C. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovascular Research. 2020; 116(6): 1097–1100. DOI: 10.1093/cvr/cvaa078
Open DOI Search in Google Scholar Back to article
Rassi A, Amato Neto V, de Siqueira AF, Ferriolli Filho F, Amato VS, Rassi Júnior A. [Protective effect of benznidazole against parasite reactivation in patients chronically infected with Trypanosoma cruzi and treated with corticoids for associated diseases]. Revista da Sociedade Brasileira de Medicina Tropical. 1999; 32(5): 475–482. DOI: 10.1590/S0037-86821999000500002
Open DOI Search in Google Scholar Back to article
dos Santos-Neto LL, Polcheira MF, Castro C, Lima RA, Simaan CK, Corrêa-Lima FA. [Trypanosoma cruzi high parasitemia in patient with systemic lupus erythematosus]. Revista da Sociedade Brasileira de Medicina Tropical. 2003; 36(5): 613–615. DOI: 10.1590/S0037-86822003000500012
Open DOI Search in Google Scholar Back to article
López L, Arai K, Giménez E, Jiménez M, Pascuzo C, Rodríguez-Bonfante C, et al. [C-reactive protein and interleukin-6 serum levels increase as Chagas disease progresses towards cardiac failure]. Revista Española de Cardiología. 2006; 59(1): 50–56. DOI: 10.1016/S1885-5857(06)60048-0
Open DOI Search in Google Scholar Back to article
Keating SM, Deng X, Fernandes F, Cunha-Neto E, Ribeiro AL, Adesina B, et al. Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease. International Journal of Cardiology. 2015; 199: 451–459. DOI: 10.1016/j.ijcard.2015.07.040
Open DOI Search in Google Scholar Back to article
Benziger CP, do Carmo GAL, Ribeiro ALP. Chagas cardiomyopathy: Clinical presentation and management in the Americas. Cardiology Clinics. 2017; 35(1): 31–47. DOI: 10.1016/j.ccl.2016.08.013
Open DOI Search in Google Scholar Back to article
Tanowitz HB, Machado FS, Spray DC, Friedman JM, Weiss OS, Lora JN, et al. Developments in the management of Chagas cardiomyopathy. Expert Review of Cardiovascular Therapy. 2015; 13(12): 1393–1409. DOI: 10.1586/14779072.2015.1103648
Open DOI Search in Google Scholar Back to article
Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, et al. COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research. 2020; 116(10): 1666–1687. DOI: 10.1093/cvr/cvaa106
Open DOI Search in Google Scholar Back to article
Schett G, Sticherling M, Neurath MF. COVID-19: Risk for cytokine targeting in chronic inflammatory diseases? Nature Reviews Immunology. 2020; 20(5): 271–272. DOI: 10.1038/s41577-020-0312-7
Open DOI Search in Google Scholar Back to article
de Araújo FF, Lima Torres KC, Viana Peixoto S, Pinho Ribeiro AL, Vaz Melo Mambrini J, Bortolo Rezende V, et al. CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: A cohort study of aging in Bambui, Brazil. Infectious diseases of poverty. 2020; 9(1): 51. DOI: 10.1186/s40249-020-00663-w
Open DOI Search in Google Scholar Back to article
Dutra WO, Menezes CA, Magalhães LM, Gollob KJ. Immunoregulatory networks in human Chagas disease. Parasite Immunology. 2014; 36(8): 377–387. DOI: 10.1111/pim.12107
Open DOI Search in Google Scholar Back to article
Siripanthong B, Nazarian S, Muser D, Deo R, Santangeli P, Khanji MY, et al. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart Rhythm. 2020; 17(9): 1463–1471. DOI: 10.1016/j.hrthm.2020.05.001
Open DOI Search in Google Scholar Back to article
Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, et al. COVID-19 and thrombotic or thromboembolic disease: Implications for prevention, antithrombotic therapy, and follow-Up: JACC state-of-the-art review. Journal of the American College of Cardiology. 2020; 75(23): 2950–2973. DOI: 10.1016/j.jacc.2020.04.031
Open DOI Search in Google Scholar Back to article
Pinazo MJ, de Posada EJ, Izquierdo L, Tassies D, Marques AF, de Lazzari E, et al. Altered hypercoagulability factors in patients with chronic Chagas disease: Potential biomarkers of therapeutic response. PLoS Neglected Tropical Diseases. 2016; 10(1): e0004269. DOI: 10.1371/journal.pntd.0004269
Open DOI Search in Google Scholar Back to article
Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, et al. Chagas cardiomyopathy: An update of current clinical knowledge and management: A scientific statement From the American Heart Association. Circulation. 2018; 138(12): e169–e209. DOI: 10.1161/CIR.0000000000000599
Open DOI Search in Google Scholar Back to article
Sosa-Estani S, Cura E, Velazquez E, Yampotis C, Segura EL. Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission. Revista da Sociedade Brasileira de Medicina Tropical. 2009; 42(5): 484–487. DOI: 10.1590/S0037-86822009000500002
Open DOI Search in Google Scholar Back to article
Fabbro DL, Danesi E, Olivera V, Codebó MO, Denner S, Heredia C, et al. Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas. PLoS Neglected Tropical Diseases. 2014; 8(11): e3312. DOI: 10.1371/journal.pntd.0003312
Open DOI Search in Google Scholar Back to article
Regueiro A, García-Álvarez A, Sitges M, Ortiz-Pérez JT, De Caralt MT, Pinazo MJ, et al. Myocardial involvement in Chagas disease: Insights from cardiac magnetic resonance. International Journal of Cardiology. 2013; 165(1): 107–12. DOI: 10.1016/j.ijcard.2011.07.089
Open DOI Search in Google Scholar Back to article
Nunes MCP, Badano LP, Marin-Neto JA, Edvardsen T, Fernández-Golfín C, Bucciarelli-Ducci C, et al. Multimodality imaging evaluation of Chagas disease: An expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI). European Heart Journal Cardiovascular Imaging. 2018; 19(4): 459–460n. DOI: 10.1093/ehjci/jex154
Open DOI Search in Google Scholar Back to article
Torreão JA, Ianni BM, Mady C, Naia E, Rassi CH, Nomura C, et al. Myocardial tissue characterization in Chagas’ heart disease by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance. 2015; 17: 97. DOI: 10.1186/s12968-015-0200-7
Open DOI Search in Google Scholar Back to article
Barros ML, Ribeiro A, Nunes Mdo C, Rocha MO. [Association between left ventricular wall motion abnormalities and ventricular arrhythmia in the indeterminate form of Chagas disease]. Revista da Sociedade Brasileira de Medicina Tropical. 2011; 44(2): 213–216. DOI: 10.1590/S0037-86822011005000020
Open DOI Search in Google Scholar Back to article
Furtado RG, Frota D, Silva JB, Romano MM, Almeida Filho OC, Schmidt A, et al. Right ventricular Doppler echocardiographic study of indeterminate form of Chagas disease. Arquivos Brasileiros de Cardiologia. 2015; 104(3): 209–217. DOI: 10.5935/abc.20140197
Open DOI Search in Google Scholar Back to article
Cianciulli TF, Saccheri MC, Papantoniou A, Méndez RJ, Gagliardi JA, Prado NG, et al. Use of tissue doppler imaging for the early detection of myocardial dysfunction in patients with the indeterminate form of Chagas disease. Revista da Sociedade Brasileira de Medicina Tropical. 2020; 53: e20190457. DOI: 10.1590/0037-8682-0457-2019
Open DOI Search in Google Scholar Back to article
Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020; 69(6): 1002–1009. DOI: 10.1136/gutjnl-2020-320926
Open DOI Search in Google Scholar Back to article
Lin L, Jiang X, Zhang Z, Huang S, Zhang Z, Fang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 2020; 69(6): 997–1001. DOI: 10.1136/gutjnl-2020-321013
Open DOI Search in Google Scholar Back to article
Nath A. Neurologic complications of coronavirus infections. Neurology. 2020; 94(19): 809–810. DOI: 10.1212/WNL.0000000000009455
Open DOI Search in Google Scholar Back to article
Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clinical Neurology and Neurosurgery. 2020; 194: 105921. DOI: 10.1016/j.clineuro.2020.105921
Open DOI Search in Google Scholar Back to article
Howard EJ, Xiong X, Carlier Y, Sosa-Estani S, Buekens P. Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta-analysis. BJOG. 2014; 121(1): 22–33. DOI: 10.1111/1471-0528.12396
Open DOI Search in Google Scholar Back to article
Kaplinski M, Jois M, Galdos-Cardenas G, Rendell VR, Shah V, Do RQ, et al. Sustained domestic vector exposure is associated with increased Chagas cardiomyopathy risk but decreased parasitemia and congenital transmission risk among young women in Bolivia. Clinical Infectious Diseases. 2015; 61(6): 918–926. DOI: 10.1093/cid/civ446
Open DOI Search in Google Scholar Back to article
Carlier Y, Altcheh J, Angheben A, Freilij H, Luquetti AO, Schijman AG, et al. Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women. PLoS Neglected Tropical Diseases. 2019; 13(10): e0007694. DOI: 10.1371/journal.pntd.0007694
Open DOI Search in Google Scholar Back to article
Buekens P, Alger J, Bréart G, Cafferata ML, Harville E, Tomasso G. A call for action for COVID-19 surveillance and research during pregnancy. The Lancet Global health. 2020; 8(7): e877–e8. DOI: 10.1016/S2214-109X(20)30206-0
Open DOI Search in Google Scholar Back to article
Sartori AM, Ibrahim KY, Nunes Westphalen EV, Braz LM, Oliveira OC, Jr, Gakiya E, et al. Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS. Annals of Tropical Medicine and Parasitology. 2007; 101(1): 31–50. DOI: 10.1179/136485907X154629
Open DOI Search in Google Scholar Back to article
Gosain R, Abdou Y, Singh A, Rana N, Puzanov I, Ernstoff MS. COVID-19 and cancer: A comprehensive review. Current Oncology Reports. 2020; 22(5): 53. DOI: 10.1007/s11912-020-00934-7
Open DOI Search in Google Scholar Back to article
Zingone F, Savarino EV. Viral screening before initiation of biologics in patients with inflammatory bowel disease during the COVID-19 outbreak. The Lancet Gastroenterology & Hepatology. 2020; 5(6): 525. DOI: 10.1016/S2468-1253(20)30085-6
Open DOI Search in Google Scholar Back to article
Manne-Goehler J, Umeh CA, Montgomery SP, Wirtz VJ. Estimating the burden of Chagas disease in the United States. PLoS Neglected Tropical Diseases. 2016; 10(11): e0005033. DOI: 10.1371/journal.pntd.0005033
Open DOI Search in Google Scholar Back to article
Lima-Costa MF, Peixoto SV, Ribeiro ALP. Chagas disease and mortality in old age as an emerging issue: 10 year follow-up of the Bambuí population-based cohort study (Brazil). International Journal of Cardiology. 2010; 145(2): 362–363. DOI: 10.1016/j.ijcard.2010.02.036
Open DOI Search in Google Scholar Back to article
Martins-Melo FR, Ramos AN, Jr, Alencar CH, Heukelbach J. Prevalence of Chagas disease in Brazil: A systematic review and meta-analysis. Acta Tropica. 2014; 130: 167–174. DOI: 10.1016/j.actatropica.2013.10.002
Open DOI Search in Google Scholar Back to article
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020; 395(10229): 1054–1062. DOI: 10.1016/S0140-6736(20)30566-3
Open DOI Search in Google Scholar Back to article
Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: A model-based analysis. The Lancet Infectious Diseases. 2020; 20(6): 669–677. DOI: 10.1016/S1473-3099(20)30243-7
Open DOI Search in Google Scholar Back to article
Centers for Disease Control. CDC COVID Data Tracker 2020 [updated June 30, 2020]. Available from: https://www.cdc.gov/covid-data-tracker/index.html#demographics.
Search in Google Scholar Back to article
Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clinical Research in Cardiology. 2020; 109(5): 531–538. DOI: 10.1007/s00392-020-01626-9
Open DOI Search in Google Scholar Back to article
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. Jama. 2020; 323(11): 1061–1069. DOI: 10.1001/jama.2020.1585
Open DOI Search in Google Scholar Back to article
Moccia F, Gerbino A, Lionetti V, Miragoli M, Munaron LM, Pagliaro P, et al. COVID-19-associated cardiovascular morbidity in older adults: A position paper from the Italian Society of Cardiovascular Researches. GeroScience. 2020; 42(4): 1021–1049. DOI: 10.1007/s11357-020-00198-w
Open DOI Search in Google Scholar Back to article
Imam Z, Odish F, Gill I, O’Connor D, Armstrong J, Vanood A, et al. Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States. Journal of Internal Medicine. 2020; 288(4). DOI: 10.1111/joim.13119
Open DOI Search in Google Scholar Back to article
Alves RM, Thomaz RP, Almeida EA, Wanderley JdaS, Guariento ME. Chagas’ disease and ageing: The coexistence of other chronic diseases with Chagas’ disease in elderly patients. Revista da Sociedade Brasileira de Medicina Tropical. 2009; 42(6): 622–628. DOI: 10.1590/S0037-86822009000600002
Open DOI Search in Google Scholar Back to article
Oliveira Junior LR, Carvalho TB, da Costa ÉAPN, Marques Pereira PC, Kurokawa CS. Cardiovascular comorbidities in patients with chronic Chagas disease. AME Medical Journal. 2018. DOI: 10.21037/amj.2018.07.01
Open DOI Search in Google Scholar Back to article
Jackson Y, Castillo S, Hammond P, Besson M, Brawand-Bron A, Urzola D, et al. Metabolic, mental health, behavioural and socioeconomic characteristics of migrants with Chagas disease in a non-endemic country. Tropical Medicine & International Health. 2012; 17(5): 595–603. DOI: 10.1111/j.1365-3156.2012.02965.x
Open DOI Search in Google Scholar Back to article
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. Jama. 2020; 323(13): 1239–1242. DOI: 10.1001/jama.2020.2648
Open DOI Search in Google Scholar Back to article
Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. Jama. 2020; 323(18): 1775–1776. DOI: 10.1001/jama.2020.4683
Open DOI Search in Google Scholar Back to article
Centers for Disease Control. Provisional death counts for coronavirus disease 2019 (COVID-19): Race and Hispanic origin 2020 [updated June 24, 2020]. Available from: https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Race_Hispanic.
Search in Google Scholar Back to article
Batista A, Antunes B, Faveret G, Peres I, Marchesi J, Cunha JP, et al. Análise socioeconômica da taxa de letalidade da COVID-19 no Brasil. Nucleo de Operacoes e Inteligencia em Saude (NOIS); 2020 May 27, 2020. Contract No.: Nota Tecnica 11. Available from: https://www.sites.google.com/view/nois-pucrio/publica%C3%A7%C3%B5es?authuser=0#h.ijqa5msfttoq
Search in Google Scholar Back to article
Baqui P, Bica I, Marra V, Ercole A, van der Schaar M. Ethnic and regional variations in hospital mortality from COVID-19 in Brazil: A cross-sectional observational study. The Lancet Global Health. 2020; 8(8): E1018–E1026. DOI: 10.1016/S2214-109X(20)30285-0
Open DOI Search in Google Scholar Back to article
Viotti R, Vigliano CA, Alvarez MG, Lococo BE, Petti MA, Bertocchi GL, et al. The impact of socioeconomic conditions on chronic Chagas disease progression. Revista Española de Cardiología. 2009; 62(11): 1224–1232. DOI: 10.1016/S1885-5857(09)73349-3
Open DOI Search in Google Scholar Back to article
United Nations. World Economic Situation and Prospects as of mid-2020. New York, NY; 2020. Available from: https://www.un.org/development/desa/dpad/wp-content/uploads/sites/45/publication/WESP2020_MYU_Report.pdf.
Search in Google Scholar Back to article
Pessoa-Amorim G, Camm CF, Gajendragadkar P, De Maria GL, Arsac C, Laroche C, et al. Admission of patients with STEMI since the outbreak of the COVID-19 pandemic: A survey by the European Society of Cardiology. European Heart Journal – Quality of Care and Clinical Outcomes. 2020; 6(3): 210–216. DOI: 10.1093/ehjqcco/qcaa046
Open DOI Search in Google Scholar Back to article
Reza N, DeFilippis EM, Jessup M. Secondary impact of the COVID-19 pandemic on patients with heart failure. Circulation: Heart Failure. 2020; 13(5): e007219. DOI: 10.1161/CIRCHEARTFAILURE.120.007219
Open DOI Search in Google Scholar Back to article
Mustafa NM, A Selim L. Characterisation of COVID-19 pandemic in paediatric age group: A systematic review and meta-analysis. Journal of Clinical Virology. 2020; 128: 104395. DOI: 10.1016/j.jcv.2020.104395
Open DOI Search in Google Scholar Back to article
Alvar J, Alves F, Bucheton B, Burrows L, Büscher P, Carrillo E, et al. Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases. Seminars in Immunopathology. 2020; 42(3): 231–46. DOI: 10.1007/s00281-020-00796-y
Open DOI Search in Google Scholar Back to article
Pan American Health Organization. Guidelines for the diagnosis and treatment of Chagas disease. Washington, DC; 2019. Available from: https://iris.paho.org/handle/10665.2/49653
Search in Google Scholar Back to article
Urbina JA. Ergosterol biosynthesis and drug development for Chagas disease. Memorias do Instituto Oswaldo Cruz. 2009; 104(Suppl1): 311–318. DOI: 10.1590/S0074-02762009000900041
Open DOI Search in Google Scholar Back to article
Bern C, Montgomery SP, Herwaldt BL, Rassi A, Jr, Marin-Neto JA, Dantas RO, et al. Evaluation and treatment of Chagas disease in the United States: A systematic review. Jama. 2007; 298(18): 2171–2181. DOI: 10.1001/jama.298.18.2171
Open DOI Search in Google Scholar Back to article
Sperandio da Silva GM, Mediano MFF, Hasslocher-Moreno AM, Holanda MTd, Sousa ASd, Sangenis LHC, et al. Benznidazole treatment safety: The Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas’ disease—Authors’ response. Journal of Antimicrobial Chemotherapy. 2018; 73(4): 1115–1116. DOI: 10.1093/jac/dkx505
Open DOI Search in Google Scholar Back to article
Pinazo MJ, Muñoz J, Posada E, López-Chejade P, Gállego M, Ayala E, et al. Tolerance of benznidazole in treatment of Chagas’ disease in adults. Antimicrobial Agents and Chemotherapy. 2010; 54(11): 4896–4899. DOI: 10.1128/AAC.00537-10
Open DOI Search in Google Scholar Back to article
Forsyth CJ, Hernandez S, Olmedo W, Abuhamidah A, Traina MI, Sanchez DR, et al. Safety profile of Nifurtimox for treatment of Chagas disease in the United States. Clinical Infectious Diseases. 2016; 63(8): 1056–1062. DOI: 10.1093/cid/ciw477
Open DOI Search in Google Scholar Back to article
Zheng Y-Y, Ma Y-T, Zhang J-Y, Xie X. COVID-19 and the cardiovascular system. Nature Reviews Cardiology. 2020; 17(5): 259–260. DOI: 10.1038/s41569-020-0360-5
Open DOI Search in Google Scholar Back to article
Libby P. The heart in COVID-19: Primary target or secondary bystander? JACC: Basic to Translational Science. 2020; 5(5): 537–542. DOI: 10.1016/j.jacbts.2020.04.001
Open DOI Search in Google Scholar Back to article
Shin J, Johnson JA. Pharmacogenetics of beta-blockers. Pharmacotherapy. 2007; 27(6): 874–887. DOI: 10.1592/phco.27.6.874
Open DOI Search in Google Scholar Back to article
Salaroglio IC, Gazzano E, Abdullrahman A, Mungo E, Castella B, Abd-Elrahman G, et al. Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer. Journal of Experimental & Clinical Cancer Research. 2018; 37(1): 286. DOI: 10.1186/s13046-018-0967-0
Open DOI Search in Google Scholar Back to article
Zaidel EJ, Quintana FSW, Sosa Liprandi A, Mendoza I, Marquez MF, Nunez E, et al. Hidroxicloroquina. Mensajes desde la cardiología en tiempos de pandemia por coronavirus [Hydroxychloroquine: Cardiology’s viewpoint in times of coronavirus pandemic]. Medicina (B Aires). 2020; 80(3): 271–274.
Search in Google Scholar Back to article
University of California-San Francisco. Interactions with Amiodarone and Antiretrovirals. 2019. Available from: http://arv.ucsf.edu/insite?page=ar-00-02&post=8&param=116.
Search in Google Scholar Back to article
Milazzo L, Cattaneo D, Cheli S, Ferraris L, Colella E, Clementi E, et al. ACE inhibitors and ribavirin-associated cough: A common undefined predisposing factor? European Journal of Clinical Pharmacology. 2013; 69(3): 743–745. DOI: 10.1007/s00228-012-1397-0
Open DOI Search in Google Scholar Back to article
DrugBank. Ivermectin 2020 [updated June 30, 2020]. Available from: https://www.drugbank.ca/drugs/DB00602.
Search in Google Scholar Back to article
DrugBank. Umifenovir 2020 [updated June 12, 2020]. Available from: https://www.drugbank.ca/drugs/DB13609.
Search in Google Scholar Back to article
Chakraborty A, Tannenbaum S, Rordorf C, Lowe PJ, Floch D, Gram H, et al. Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody. Clinical Pharmacokinetics. 2012; 51(6): e1–e18. DOI: 10.2165/11599820-000000000-00000
Open DOI Search in Google Scholar Back to article
Novartis Pharmaceuticals Corporation. ILARIS (canakinumab) Full Prescribing Information 2012.
Search in Google Scholar Back to article
Patheon Italia. GAMIFANTTM (emapalumab-lzsg) injection, for intravenous use. 2018.
Search in Google Scholar Back to article
Janssen Biotech. SYLVANT. Full Prescribing Information 2014.
Search in Google Scholar Back to article
Campana C, Regazzi MB, Buggia I, Molinaro M. Clinically significant drug interactions with cyclosporin. An update. Clinical Pharmacokinetics. 1996; 30(2): 141–179. DOI: 10.2165/00003088-199630020-00004
Open DOI Search in Google Scholar Back to article
Lill J, Bauer LA, Horn JR, Hansten PD. Cyclosporine–drug interactions and the influence of patient age. American Journal of Health-System Pharmacy. 2000; 57(17): 1579–1584. DOI: 10.1093/ajhp/57.17.1579
Open DOI Search in Google Scholar Back to article
Pfizer Inc. RAPAMUNE. 2017.
Search in Google Scholar Back to article
Janssen Pharmaceutical Companies. PREZCOBIX (darunavir and cobicistat) tablets, for oral use. 2019.
Search in Google Scholar Back to article
Paranjpe I, Fuster V, Lala A, Russak AJ, Glicksberg BS, Levin MA, et al. Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19. Journal of the American College of Cardiology. 2020; 76(1): 122–124. DOI: 10.1016/j.jacc.2020.05.001
Open DOI Search in Google Scholar Back to article
Sousa AS, Xavier SS, Freitas GR, Hasslocher-Moreno A. Prevention strategies of cardioembolic ischemic stroke in Chagas’ disease. Arquivos Brasileiros de Cardiologia. 2008; 91(5): 306–310. DOI: 10.1590/S0066-782X2008001700004
Open DOI Search in Google Scholar Back to article

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DOI: https://doi.org/10.5334/gh.891 | Journal eISSN: 2211-8179

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Language: English

Submitted on: Jul 28, 2020

Accepted on: Sep 16, 2020

Published on: Oct 13, 2020

Published by: Ubiquity Press

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

COVID-19,

Chagas Disease,

Neglected Tropical Disease

© 2020 Ezequiel José Zaidel, Colin J. Forsyth, Gabriel Novick, Rachel Marcus, Antonio Luiz P. Ribeiro, María-Jesus Pinazo, Carlos A. Morillo, Luis Eduardo Echeverría, Maria Aparecida Shikanai-Yasuda, Pierre Buekens, Pablo Perel, Sheba K. Meymandi, Kate Ralston, Fausto Pinto, Sergio Sosa-Estani, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 15 (2020): Issue 1