Cost-Effectiveness of Improved Hypertension Management in India through Increased Treatment Coverage and Adherence: A Mathematical Modeling Study
References
- WHO.
Cardiovascular diseases (CVDs) – Fact Sheet . World Health Organ 2017.https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (accessed July 2, 2020). - Bloom D, Cafiero E, McGovern M, Prettner K, Stanciole A, Weiss J, et al.
The economic impact of non-communicable disease in China and India: Estimates, projections, and comparisons . Cambridge, MA: National Bureau of Economic Research; 2013. DOI: 10.3386/w19335 - Global Burden of Disease Collaborative Network.
Global Burden of Disease Study 2017 (GBD 2017) Results . Seattle, United States: Institute for Health Metrics and Evaluation (IHME); 2018. - Huffman MD, Rao KD, Pichon-Riviere A, Zhao D, Harikrishnan S, Ramaiya K, et al. A cross-sectional study of the microeconomic impact of cardiovascular disease hospitalization in four low- and middle-income countries. PLoS ONE. 2011; 6:
e20821 . DOI: 10.1371/journal.pone.0020821 - Campbell NRC, Lackland DT, Niebylski ML, the World Hypertension League and International Society of Hypertension Executive Committees. High blood pressure: why prevention and control are urgent and important-A 2014 fact sheet from the World Hypertension League and the International Society of Hypertension. J Clin Hypertens. 2014; 16: 551–3. DOI: 10.1111/jch.12372
- Kontis V, Cobb LK, Mathers CD, Frieden TR, Ezzati M, Danaei G. Three public health interventions could save 94 million lives in 25 years: Global impact assessment analysis. Circulation. 2019; 140: 715–25. DOI: 10.1161/CIRCULATIONAHA.118.038160
- Lloyd-Sherlock P, Beard J, Minicuci N, Ebrahim S, Chatterji S. Hypertension among older adults in low- and middle-income countries: Prevalence, awareness and control. Int J Epidemiol. 2014; 43: 116–28. DOI: 10.1093/ije/dyt215
- Prenissl J, Manne-Goehler J, Jaacks LM, Prabhakaran D, Awasthi A, Bischops AC, et al. Hypertension screening, awareness, treatment, and control in India: A nationally representative cross-sectional study among individuals aged 15 to 49 years. PLOS Med. 2019; 16:
e1002801 . DOI: 10.1371/journal.pmed.1002801 - Frieden TR, Varghese CV, Kishore SP, Campbell NRC, Moran AE, Padwal R, et al. Scaling up effective treatment of hypertension—A pathfinder for universal health coverage. J Clin Hypertens. 2019; 21: 1442–9. DOI: 10.1111/jch.13655
- Atun R, Jaffar S, Nishtar S, Knaul FM, Barreto ML, Nyirenda M, et al. Improving responsiveness of health systems to non-communicable diseases. The Lancet. 2013; 381: 690–7. DOI: 10.1016/S0140-6736(13)60063-X
- The Indian Council of Medical Research.
Press Release: Expansion for India Hypertension Control Initiative (IHCI) . New Delhi: The Indian Council of Medical Research; 2019. - Jaffe MG, Young JD. The Kaiser Permanente Northern California Story: Improving hypertension control from 44% to 90% in 13 years (2000 to 2013). J Clin Hypertens. 2016; 18: 260–1. DOI: 10.1111/jch.12803
- WHO.
HEARTS Technical Package . WHO n.d.http://www.who.int/cardiovascular_diseases/hearts/en/ (accessed March 6, 2020). - Lim SS, Gaziano TA, Gakidou E, Reddy KS, Farzadfar F, Lozano R, et al. Prevention of cardiovascular disease in high-risk individuals in low-income and middle-income countries: health effects and costs. The Lancet. 2007; 370: 2054–62. DOI: 10.1016/S0140-6736(07)61699-7
- Hedayati SS, Elsayed EF, Reilly RF. Non-pharmacological aspects of blood pressure management: What are the data? Kidney Int. 2011; 79: 1061–70. DOI: 10.1038/ki.2011.46
- Migneault JP, Dedier JJ, Wright JA, Heeren T, Campbell MK, Morisky DE, et al. A culturally adapted telecommunication system to improve physical activity, diet quality, and medication adherence among hypertensive African-Americans: A randomized controlled trial. Ann Behav Med. 2012; 43: 62–73. DOI: 10.1007/s12160-011-9319-4
- Ajay VS, Jindal D, Roy A, Venugopal V, Sharma R, Pawar A, et al. Development of a smartphone-enabled hypertension and diabetes mellitus management package to facilitate evidence-based care delivery in primary healthcare facilities in India: The mPower Heart Project. J Am Heart Assoc. 2016; 5:
e004343 . DOI: 10.1161/JAHA.116.004343 - Praveen D, Patel A, McMahon S, Prabhakaran D, Clifford GD, Maulik PK, et al. A multifaceted strategy using mobile technology to assist rural primary healthcare doctors and frontline health workers in cardiovascular disease risk management: Protocol for the SMARTHealth India cluster randomised controlled trial. Implement Sci. 2013; 8: 1–8. DOI: 10.1186/1748-5908-8-137
- Engelgau MM, Karan A, Mahal A. The economic impact of non-communicable diseases on households in India. Glob Health. 2012; 8: 9. DOI: 10.1186/1744-8603-8-9
- Babu V, Sahu SK, Kanungo S. Hypertension control status and quality of care for hypertension among patients availing treatment from private sector: A cross-sectional study in urban field practice area of JIPMER, Puducherry. J Fam Med Prim Care. 2019; 8: 72–6. DOI: 10.4103/jfmpc.jfmpc_248_18
- Balarajan Y, Selvaraj S, Subramanian S. Health care and equity in India. The Lancet. 2011; 377: 505–15. DOI: 10.1016/S0140-6736(10)61894-6
- Bilinski A, Neumann P, Cohen J, Thorat T, McDaniel K, Salomon JA. When cost-effective interventions are unaffordable: Integrating cost-effectiveness and budget impact in priority setting for global health programs. PLOS Med. 2017; 14:
e1002397 . DOI: 10.1371/journal.pmed.1002397 - Kostova D, Spencer G, Moran AE, Cobb LK, Husain MJ, Datta BK, et al. The cost-effectiveness of hypertension management in low-income and middle-income countries: A review. BMJ Glob Health. 2020; 5:
e002213 . DOI: 10.1136/bmjgh-2019-002213 - Kowal P, Chatterji S, Naidoo N, Biritwum R, Fan W, Lopez Ridaura R, et al. Data Resource Profile: The World Health Organization study on global ageing and adult health (SAGE). Int J Epidemiol. 2012; 41: 1639–49. DOI: 10.1093/ije/dys210
- Ueda P, Woodward M, Lu Y, Hajifathalian K, Al-Wotayan R, Aguilar-Salinas CA, et al. Laboratory-based and office-based risk scores and charts to predict 10-year risk of cardiovascular disease in 182 countries: A pooled analysis of prospective cohorts and health surveys. Lancet Diabetes Endocrinol. 2017; 5: 196–213. DOI: 10.1016/S2213-8587(17)30015-3
- James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2018; 392: 1789–858. DOI: 10.1016/S0140-6736(18)32279-7
- WHO.
Global Health Observatory data repository . Geneva: World Health Organization; 2018. - Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009; 338: b1665. DOI: 10.1136/bmj.b1665
- Huffman MD, Mohanan PP, Devarajan R, Baldridge AS, Kondal D, Zhao L, et al. Effect of a quality improvement intervention on clinical outcomes in patients in India with acute myocardial infarction: The ACS QUIK randomized clinical trial. JAMA. 2018; 319: 567–78. DOI: 10.1001/jama.2017.21906
- Pandian JD, Sudhan P. Stroke epidemiology and stroke care services in India. J Stroke. 2013; 15: 128–34. DOI: 10.5853/jos.2013.15.3.128
- Steg PhG, Bhatt DL, Wilson PWF, D’Agostino R, Ohman EM, Röther J, et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007; 297: 1197–206. DOI: 10.1001/jama.297.11.1197
- Petty GW, Brown RD, Whisnant JP, Sicks JD, O’Fallon WM, Wiebers DO. Survival and recurrence after first cerebral infarction: A population-based study in Rochester, Minnesota, 1975 through 1989. Neurology. 1998; 50: 208–16. DOI: 10.1212/WNL.50.1.208
- Lin JK, Moran AE, Bibbins-Domingo K, Falase B, Pedroza Tobias A, Mandke CN, et al. Cost-effectiveness of a fixed-dose combination pill for secondary prevention of cardiovascular disease in China, India, Mexico, Nigeria, and South Africa: A modelling study. Lancet Glob Health. 2019; 7: e1346–58. DOI: 10.1016/S2214-109X(19)30339-0
- Chow CK, Teo KK, Rangarajan S, Islam S, Gupta R, Avezum A, et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013; 310: 959–68. DOI: 10.1001/jama.2013.184182
- Van Wijk BL, Klungel OH, Heerdink ER, de Boer A. Rate and determinants of 10-year persistence with antihypertensive drugs: JHypertens. 2005; 23: 2101–7. DOI: 10.1097/01.hjh.0000187261.40190.2e
- Dennis T, Meera NK, Binny K, Sekhar MS, Kishore G, Sasidharan S. Medication adherence and associated barriers in hypertension management in India. CVD Prev Control. 2011; 6: 9–13. DOI: 10.1016/j.cvdpc.2010.11.001
- Bellows BK, Ruiz-Negrón N, Bibbins-Domingo K, King JB, Pletcher MJ, Moran AE, et al. Clinic-based strategies to reach united states million hearts 2022 blood pressure control goals: A simulation study. Circ Cardiovasc Qual Outcomes. 2019; 12:
e005624 . DOI: 10.1161/CIRCOUTCOMES.118.005624 - Smolina K, Wright FL, Rayner M, Goldacre MJ. Long-term survival and recurrence after acute myocardial infarction in England, 2004 to 2010. Circ Cardiovasc Qual Outcomes. 2012; 5: 532–40. DOI: 10.1161/CIRCOUTCOMES.111.964700
- Jaffe MG, Frieden TR, Campbell NRC, Matsushita K, Appel LJ, Lackland DT, et al. Recommended treatment protocols to improve management of hypertension globally: A statement by Resolve to Save Lives and the World Hypertension League (WHL). J Clin Hypertens. 2018; 20: 829–36. DOI: 10.1111/jch.13280
- India Hypertension Management Intiative. Punjab Hypertension Protocol n.d.
- Cherry SB, Benner JS, Hussein MA, Tang SSK, Nichol MB. The clinical and economic burden of nonadherence with antihypertensive and lipid-lowering therapy in hypertensive patients. Value Health. 2009; 12: 489–97. DOI: 10.1111/j.1524-4733.2008.00447.x
- TSMSIDC.
Medicines-Rate Contract . Telangana State Med Serv Infrastruct Dev Corp n.d.http://tsmsidc.telangana.gov.in/content.php?U=20%20&&%20T=Medicines-Rate%20Contract (accessed January 7, 2020). - 1mg. About 1mg: India’s leading digital consumer healthcare platform 2020.
https://www.1mg.com/aboutUs (accessed May 15, 2020). - Prinja S, Chauhan AS, Bahuguna P, Selvaraj S, Muraleedharan VR, Sundararaman T. Cost of delivering secondary healthcare through the public sector in India. PharmacoEconomics. 2020; 4: 249–61. DOI: 10.1007/s41669-019-00176-9
- Central Government Health Scheme, GoI.
Rate List for Hyderabad – CGHS Hyderabad w.e.f 17/11/2014 . Hyderabad, India: Government of India; 2014. - WHO.
Country-specific inpatient and outpatient estimates in 2010 currency . Geneva: World Health Organization; 2010. - MSH.
International Medical Products Price Guide . Arlington, Virginia: Management Sciences for Health; 2016. - Salomon JA, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, et al. Common values in assessing health outcomes from disease and injury: Disability weights measurement study for the Global Burden of Disease Study 2010. The Lancet. 2012; 380: 2129–43. DOI: 10.1016/S0140-6736(12)61680-8
- WHO. Community drug distribution at doorsteps: Essential health services decentralized to care for hypertensives under the IHCI initiative 2020.
https://www.who.int/india/news/feature-stories/detail/community-drug-distribution-at-doorsteps-essential-health-services-decentralized-to-care-for-hypertensives-under-the-ihci-initiative (accessed August 23, 2020). - Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: Terminology and definitions. Value Health. 2008; 11: 44–7. DOI: 10.1111/j.1524-4733.2007.00213.x
- Basu S, Bendavid E, Sood N. Health and economic implications of national treatment coverage for cardiovascular disease in India: Cost-effectiveness analysis. Circ Cardiovasc Qual Outcomes. 2015; 8: 541–51. DOI: 10.1161/CIRCOUTCOMES.115.001994
- Rau N, Nayak SK.
Practical Guidelines for Hypertension Management . Med. Update 2013, Mumbai, India: The Association of Physicians of India; 2013; 69–73. - IMF.
World Economic Outlook, October 2019 . Washington, DC: International Monetary Fund; 2019. - Marseille E, Larson B, Kazi DS, Kahn JG, Rosen S. Thresholds for the cost-effectiveness of interventions: alternative approaches. Bull World Health Organ. 2015; 93: 118–24. DOI: 10.2471/BLT.14.138206
- Leech AA, Kim DD, Cohen JT, Neumann PJ. Use and misuse of cost-effectiveness analysis thresholds in low- and middle-income countries: Trends in cost-per-DALY studies. Value Health. 2018; 21: 759–61. DOI: 10.1016/j.jval.2017.12.016
- Woods B, Revill P, Sculpher M, Claxton K. Country-level cost-effectiveness thresholds: Initial estimates and the need for further research. Value Health. 2016; 19: 929–35. DOI: 10.1016/j.jval.2016.02.017
- Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D, et al. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement. BMJ. 2013; 346: f1049. DOI: 10.1136/bmj.f1049
- Rosendaal NTA, Hendriks ME, Verhagen MD, Bolarinwa OA, Sanya EO, Kolo PM, et al. Costs and cost-effectiveness of hypertension screening and treatment in adults with hypertension in rural nigeria in the context of a health insurance program. PLOS ONE. 2016; 11:
e0157925 . DOI: 10.1371/journal.pone.0157925 - Akkazieva B, Chisholm D, Akunov N, Jakab M.
The health effects and costs of the interventions to control cardiovascular disease in Kyrgyzstan . Bishkek, Kyrgyz Republic: WHO; 2009. - Nguyen T-P-L, Wright EP, Nguyen T-T, Schuiling-Veninga CCM, Bijlsma MJ, Nguyen T-B-Y, et al. Cost-effectiveness analysis of screening for and managing identified hypertension for cardiovascular disease prevention in Vietnam. PLOS ONE. 2016; 11:
e0155699 . DOI: 10.1371/journal.pone.0155699 - Gaziano T, Abrahams-Gessel S, Surka S, Sy S, Pandya A, Denman CA, et al. Cardiovascular disease screening by community health workers can be cost-effective in low-resource countries. Health Aff. (Millwood) 2015; 34: 1538–45. DOI: 10.1377/hlthaff.2015.0349
- Gheorghe A, Griffiths U, Murphy A, Legido-Quigley H, Lamptey P, Perel P. The economic burden of cardiovascular disease and hypertension in low- and middle-income countries: A systematic review. BMC Public Health. 2018; 18: 975. DOI: 10.1186/s12889-018-5806-x
- Gu D, He J, Coxson PG, Rasmussen PW, Huang C, Thanataveerat A, et al. The cost-effectiveness of low-cost essential antihypertensive medicines for hypertension control in China: A modelling study. PLOS Med. 2015; 12:
e1001860 . DOI: 10.1371/journal.pmed.1001860 - Gad M, Lord J, Chalkidou K, Asare B, Lutterodt MG, Ruiz F. Supporting the development of evidence-informed policy options: An economic evaluation of hypertension management in Ghana. Value Health. 2020; 23: 171–9. DOI: 10.1016/j.jval.2019.09.2749
- Fontana M, Asaria P, Moraldo M, Finegold J, Hassanally K, Manisty CH, et al. Patient-accessible tool for shared decision making in cardiovascular primary prevention: Balancing Longevity benefits against medication disutility. Circulation. 2014; 129: 2539–46. DOI: 10.1161/CIRCULATIONAHA.113.007595
- Moran AE, Odden MC, Thanataveerat A, Tzong KY, Rasmussen PW, Guzman D, et al. Cost-effectiveness of hypertension therapy according to 2014 guidelines. N Engl J Med. 2015; 372: 447–55. DOI: 10.1056/NEJMsa1406751
- World Health Organization.
WHO package of essential noncommunicable (PEN) disease interventions for primary health care . Geneva: World Health Organization; 2020. - Reddy TsK, Kunwar A, Durgad K, Tullu F, Sreedhar C, Wassey A, et al. Decentralization of India Hypertension Control Initiative services to maintain continuum of care for hypertensive patients during COVID-19 pandemic in Telangana. WHO South-East Asia J Public Health. 2021; 10: 49. DOI: 10.4103/2224-3151.309873
- Adler AJ, Prabhakaran D, Bovet P, Kazi DS, Mancia G, Mungal-Singh V, et al. Reducing cardiovascular mortality through prevention and management of raised blood pressure: A World Heart Federation roadmap. Glob Heart. 2015; 10: 111. DOI: 10.1016/j.gheart.2015.04.006
- Reeves A, Gourtsoyannis Y, Basu S, McCoy D, McKee M, Stuckler D. Financing universal health coverage—Effects of alternative tax structures on public health systems: cross-national modelling in 89 low-income and middle-income countries. The Lancet. 2015; 386: 274–80. DOI: 10.1016/S0140-6736(15)60574-8
- Press Information Bureau.
Ayushman Bharat for a new India -2022, announced . New Delhi: Government of India; 2018. - Sharma NC.
Health budget focuses only on Ayushman Bharat, other schemes ignored . Livemint 2019. - Bakshi H, Sharma R, Kumar P. Ayushman Bharat Initiative (2018): What we stand to gain or lose! Indian J Community Med Off Publ Indian Assoc Prev Soc Med. 2018; 43: 63–6. DOI: 10.4103/ijcm.IJCM_96_18
- Prinja S, Chauhan AS, Karan A, Kaur G, Kumar R. Impact of publicly financed health insurance schemes on healthcare utilization and financial risk protection in India: A systematic review. PLOS ONE. 2017; 12:
e0170996 . DOI: 10.1371/journal.pone.0170996 - Ministry of Finance.
Union Budget . Delhi, India: Government of India; 2019. - The World Bank.
World Bank Open Data . Washington, DC: The World Bank; 2014. - Dandona L, Dandona R, Kumar GA, Shukla DK, Paul VK, Balakrishnan K, et al. Nations within a nation: Variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study. The Lancet. 2017; 390: 2437–60. DOI: 10.1016/S0140-6736(17)32804-0
- Bahl VK, Jadhav UM, Thacker HP. Management of hypertension with the fixed combination of perindopril and amlodipine in daily clinical practice: Results from the STRONG prospective, observational, multicenter study. Am J Cardiovasc Drugs. 2009; 9: 135–42. DOI: 10.1007/BF03256570
- Kumbla DK, Kumar S, Reddy YV, Trailokya A, Naik M. WIN OVER study: Efficacy and safety of olmesartan in Indian hypertensive patients: Results of an open label, non-comparative, multi-centric, post marketing observational study. Indian Heart J. 2014; 66: 340–4. DOI: 10.1016/j.ihj.2014.05.002
- Mathers CD. History of global burden of disease assessment at the World Health Organization. Arch Public Health. 2020; 78: 77. DOI: 10.1186/s13690-020-00458-3
- Yoon S-J, Kim Y-E, Kim E-J. Why they are different: based on the burden of disease research of WHO and Institute for Health Metrics and Evaluation. BioMed Res Int. 2018; 2018: 1–4. DOI: 10.1155/2018/7236194
DOI: https://doi.org/10.5334/gh.952 | Journal eISSN: 2211-8179
Language: English
Submitted on: Nov 11, 2020
Accepted on: Apr 20, 2021
Published on: May 10, 2021
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© 2021 Hemanshu Das, Andrew E. Moran, Anupam K. Pathni, Bhawna Sharma, Abhishek Kunwar, Sarang Deo, published by Ubiquity Press
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