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The Danish Ibbis Trials for Sickness Absentees with Common Mental Disorders: A Phase 4 Prospective Study Comparing Randomized Trial and Real-World Data Cover

The Danish Ibbis Trials for Sickness Absentees with Common Mental Disorders: A Phase 4 Prospective Study Comparing Randomized Trial and Real-World Data

Open Access
|Jul 2024

Figures & Tables

Figure 1

Composition of intervention components. “IBBIS” is a Danish acronym translating to “Integrated Health Care and Vocational Rehabilitation for Sick-Leave Benefit Recipients”.

Table 1

Baseline characteristics.

RCT-INTREAL WORLD-INTp-VALUE
n =302151
Sex (male)90 (29,8%)48 (31,8%)0.745
Age43.17 (SD: 10,12)42.72 (SD: 11,11)0.676
Diagnosis: Anxiety, other53 (17,5%)19 (12,6%)0.234
Diagnosis: Anxiety, social14 (4,6%)12 (7,9%)
Diagnosis: Exhaustion disorder86 (28,5%)40 (26,5%)
Diagnosis: Depression, mild/moderate80 (26,5%)48 (31,8%)
Diagnosis: Depression, severe26 (8,6%)17 (11,3%)
Diagnosis: Stress43 (14,2%)15 (9,9%)
Benefit history (no transfer in last 2 years)74.84 (24,4%)71.69 (28,07%)0.604
Weeks on unemployment insurance (within 2 years)7.36 (SD: 16,63)8.99 (SD: 19,41)0.875
Education (weeks within 2 years)0.52 (SD: 3,6)0.83 (SD: 4,68)0.570
Sickness benefit (weeks within 2 years)15.52 (SD: 9,91)16.54 (SD: 10,55)0.162
Parent leave (weeks within 2 years)3.30 (SD: 11,9)3.26 (SD: 12,2)0.854
Subsidized employment (weeks within 2 years)0.24 (SD: 4,14)0.53 (SD: 6,51)0.617
Unemployment benefit (weeks within 2 years)0.37 (SD: 3,25)0.50 (SD: 3,67)0.826
Table 2

Vocational outcomes. +: primary outcome. Ratio estimates are odds ratios for the binary outcomes and rate ratios for rate of weeks in employment.

OUTCOMES MEASUREESTIMATEp-VALUERCT-INT (n = 302)REAL WORLD-INT (n = 151)
RATIOS (95% CI)MEAN/N (SD/%)MEAN/N (SD/%)
At any point within 24 months, n (%)0.60 (0.38, 0.94)0.027235 (77.8%)88 (67.7%)
At any point within 12 months, n (%)+0.51 (0.35, 0.76)0.001195 (64.6%)73 (48.3%)
At any point within 6 months, n (%)0.73 (0.47, 1.12)0.14998 (32.5%)39 (25.8%)
Weeks within 24 months, mean (SD)0.70 (0.56, 0.84)0.00043.3 (SD: 33.2)30.3 (SD: 29.6)
Weeks within 12 months, mean (SD)0.68 (0.54, 0.85)0.00014.5 (SD: 14.3)9.9 (SD: 12.6)
Weeks within 6 months, mean (SD)0.56 (0.37, 0.82)0.0002.7 (SD: 4.9)1.5 (SD: 3.4)
Status at 24 months, n (%)0.53 (0.35, 0.80)0.002176 (58.3%)55 (42.3%)
Status at 12 months, n (%)0.43 (0.28, 0.64)0.000162 (53.6%)50 (33.1%)
Status at 6 months, n (%)0.73 (0.47, 1.14)0.16493 (30.8%)37 (24.5%)
Figure 2

Proportion in stable work, per week. Red line: Real world-INT; Greenish line: RCT-INT.

DOI: https://doi.org/10.5334/ijic.7562 | Journal eISSN: 1568-4156
Language: English
Submitted on: Dec 29, 2022
Accepted on: Jul 10, 2024
Published on: Jul 26, 2024
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2024 Andreas Hoff, Anders Bo Bojesen, Lene Falgaard Eplov, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.