Ryc 1
![Umiejscowienie sirtuin w komórce; SIRT1-SIRT7: sirtuiny 1–7; wg [15, 40], zmodyfikowano](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647088b271e4585e08a9f607/j_01.3001.0014.7866_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=ASIA6AP2G7AKCDONMZAN%2F20260306%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Date=20260306T042334Z&X-Amz-Expires=3600&X-Amz-Security-Token=IQoJb3JpZ2luX2VjEBAaDGV1LWNlbnRyYWwtMSJGMEQCIB8ZCgA%2BITwkrLg4cnkcH0tVrg7wv5sK6alW9sKaRKxzAiBBSg5OmnF7%2F1jtCsDBMVYEynvzFRAKOE5xlECGOFxzlirGBQjZ%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F8BEAIaDDk2MzEzNDI4OTk0MCIMSh2Fvmj%2BYJ6%2BFiFHKpoFcxj2xw7KvISCwH1sZjbeZrm00ICCP6Ukh2jgPIW0Liw5GZ5l1kxqph5PPXSq%2FYvg6PnJLnN%2BZdjqeAdSvDsQekqaIvGVEgidsjTbdoD3Qac7xVsRfX%2Fkva6c1f1mJLf2TevyZNPjmi4Xm2xareLUjdbR5hhtppSbX%2FRQMWPVDj6L3Q00KxoVWSVGHahflQP5Y1tJC1FdWR6oJ8HzmCNYUVP%2BJJbovvAwHYo8RPeKdRT7HgVqkwhu7ldFezF9LLxyi3a0SDJWicZE%2BdMgj3BJ5EulZodXYi2y3ogTvD0X064DGdaNILr2%2F9zjb4hEv%2B095o9ggYM0HV5Ygh1ymP2%2B%2BaSPPOIUaAhrt00KEmBdrJ%2FKxhKTzbNTrDwITf0TVMY0o04xGx7OZK1CgTxOpw2XkvGF4i3I2gI4ShVJZKPJFO0KqC0Sp0TSweAsE78NaLHzGMMHf74p5WheUWQPLNFIW3jO3Isxmi9q66jxGjVxOpXkGshxVgQrdStFsf1HYc3AJQEfeE2nQudzOjb7uVAgcqzahmsjQWKAxtQRbkzL6w9DejusPhGbTxH71UtCi542QG%2BSD1uA%2BmDvykaxiQD%2FI3SeA9sNZPikPCHfEBCzVgWI8x%2Bk8WoKArWdR8T%2FnVTjZi11bSozZIFQaoBJtjmn6AiEAA9NDvf2RqXB1B9uPCrX24Xi%2FotmhYXlm8BQA0wZQUvViJtCV1MfXvbd1GDkrMKQGe8fBahc8nwqhfJV5avSfUVeoR73%2F8MrVDKtiFoROZroDCOz4YmHkAKTxo%2BRVy%2FmfwJ5i%2FBl4auh%2FhqHz0IytWov2IKe3e2b3De40ODEX6YMNzsi03FkO1MrE7ZIp1q3MwjDbQPj18YrM2VLli4MvwZj7VtiWjanML2lqM0GOrIBP1LbySlujbP5H1A2gMMwwOQT7ZmxjRmm4tl%2B4oybsf2c378wHG%2BZjULMnmT4PpLnDc5B2Cq44GWkuqyURa2pGjJfMxWw%2BJiWgp2ix1pBBhMsxWMF1hPgBlgofobwrYWzcBNmxYXejlDmSou1sXRDnOhq9KFI4YAb9UNzvB1RNW1YlY6ndwwkGMCOaj1i%2FQH4ccph1FLpoOEUug4IesZijcbW8l2js12WkoIZVsT3s60QVA%3D%3D&X-Amz-Signature=583b69d2f997f71d12a077f34ec90eaf191b270b84f6f3bf3378dd585148c9ab&X-Amz-SignedHeaders=host&x-amz-checksum-mode=ENABLED&x-id=GetObject)
Rodzina sirtuin, ich struktura, lokalizacja docelowa, główne substraty aktywności katalitycznej
| Sirtuiny ludzkie (umiejscowienie genu) [10] | Lokalizacja docelowa [40] | Substraty: [histonowe (H), niehistonowe (NH)] | Schemat struktury białkowej* |
|---|---|---|---|
| SIRT1 (10q21.3) | jądro komórkowe, cytoplazma | H: H4K16, H3K9, H1K26, | około 82 kDa [35, 91]
|
| NH: FoxO, Ku70, p53, SREBP, TAFI68, PGAM1, UCP2, NF-κB, PGC1α, PPARγ | |||
| SIRT2 (19q13.1) | jądro komórkowe, cytoplazma | H: H4K16, H3K6, H4K8 | 42 kDa [35]
|
| NH: FoxO3a, FoxO1, α-tubulina, PEPCK1 | |||
| SIRT3 (11p15.5) | mitochondrium | H: H3K9, H4K16 | forma dłuższa : 44 kDa [35] forma krótsza: 28 kDa [86]
|
| NH: FoxO3a, Ku70, GDH, SDH, OGG1 | |||
| SIRT4 (12q) | mitochondrium | H: H3K9, H3K56 | 44 kDa [35]
|
| NH: HIF1α, GCN5, CtIP, DNA-PK, PARP1 | |||
| SIRT5 (6p25) | mitochondrium, cytoplazma, jądro komórkowe | NH: SDH, GLS, CPS1, PDC, UOX, HMGCS2 | 34 kDa [35, 91]
|
| SIRT6 (19p13.3) | jądro komórkowe | H: H3K9, H3K56 | 39 kDa [35]
|
| NH: HIF1α, GCN5, CtIP, DNA-PK, PARP1 | |||
| SIRT7 (17q25) | jądro komórkowe | H: H3K18, H3K122 | 48 kDa [35]
|
| NH: HIF1α, HIF2α, Myc, GABPβ1, PAF53, kompleks ligazy ubikwitynowej, polimeraza III | |||