The book features a primer on general aspects of cellular biomechanics and the experimental methods and equipment commonly used for investigating cellular mechanotransduction in vitro in two dimensional cultures in which cells are adherent to plastic surfaces. Characteristic mechanotransduction pathways in mesenchymal stem cells (MSCs) chondrocytes osteoblasts and fibroblasts are described in the accompanying chapters. Finally a description of clinical implementation of mechanical stimulation is presented with emphasis on distraction osteogenesis involving osteoblast stimulation and skin stretching techniques based on fibroblast stimulation.
This monograph is a useful reference for readers involved in graduate courses or basic research in cell biology and musculoskeletal physiology.
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