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A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients Cover

A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients

Annals of Global Health
Volume 87 (2021): Issue 1
By: Morteza Arab-Zozani,  Setare Kheyrandish,  Amirhossein Rastgar and  Ebrahim Miri-Moghadam  
Open Access
|Jun 2021
Figures & tables

Figures & Tables

Figure 1

PRISMA flow diagram.

Table 1

Summary characteristics of included studies.

AUTHOR NAME, YEARCOUNTRYSTUDY DESIGNSOURCE OF DATASAMPLE SIZEGENDERAGE
(MALE %)(MEAN ± SD)
Al akhras et al., 2016EgyptCross-sectionalClinical data1005414.2 ± 1.37
Aldemir-Kocabas et al., 2014TurkeyCase-controlmedical record4136.512.4 ± 5.4
Aleem et al., 2000Saudi-Arabiaretrospectivecase records10NR13.6
Altıncık et al., 2016TurkeyCross-sectionalmedical record4548.812.39 ± 3.72
Aydinok et al., 2002TurkeyCross-sectionalmedical record3756.714.8 ± 4.9
Beshlawy et al., 2010EgyptCross-sectionalClinical data and medical record306013.8 ± 1.7
Canatan et al., 2013TurkeyCross-sectionalquestionnaire24654.815.3 ± 8.6
Chhabra et al., 2016IndiaCase controlquestionnaire114638-16 y
Low et al., 1998ChinaCross sectionalClinical data7146.42.1-25
Dama et al., 2015IndiaCross-sectionalMedical records12558.46 Months-18
Dayasiri et al., 2018Sri LankaCase controlquestionnaire40NR17
Dayer et al., 2012IranCase controlClinical data30NR14.1
De Sanctis et al., 2017MultinationalCross-sectionalquestionnaire3023NRNR
De Sanctis et al., 2018MultinationalCross-sectionalquestionnaire3156NRNR
Dhouib et al., 2018TunisiaCross-sectionalClinical data2857.119 ± 4.54
Domrongkit et al., 2003ThailandCross-sectionalClinical data1844.429.2 ± 2.5
Doulgeraki et al., 2012GreeceCross-sectionalClinical data3852.65-18
Eshraghi et al., 2011IranCross-sectionalquestionnaire13043.120.95 ± 7.8
Fahim et al., 2013EgyptCase controlClinical data100NR7.35 ± 4.7
Fica et al., 2005RomaniaCross-sectionalClinical data and Medical records6453.119.45 ± 6.82
Garcia et al., 1993SpainCross-sectionalClinical data104018.9 ± 9.8
Grundy et al., 1994EnglandCross-sectionalClinical data1861.112.8
Gulati et al., 2000IndiaCase-controlClinical data8467.86.6 ± 4.9
Gurlek et al., 2017TurkeyCross-sectionalClinical data2437.57.1
Habeb et al., 2013Saudi ArabiaCross-sectionalClinical data8151.812.2 ± 6.85
Hamidah et al., 2001MalaysiaCase controlClinical data6654.52 -24
Hamidieh et al., 2018IranCross sectionalClinical data203010.8 ± 3.9
Hattab et al., 2013QatarCross sectionalClinical data5457.411.6 ± 3.2
Ibrahim et al., 2017PakistanCross sectionalClinical data7248.610-20
Isik et al., 2014TurkeyCross sectionalClinical data4755.310.0 ± 4.5
Jain et al., 1995IndiaCase controlClinical data257210.3 ± 3.6
Kanbour et al., 2018QatarCross sectionalClinical data2462.521.75 ± 8.05
Karamifar et al., 2002IranCross sectionalClinical data1505614.4 ± 2.8
Karamifar et al., 2005IranCross-sectionalClinical data14657.310-22
Karamifar et al., 2010IranCase controlClinical data504814.2 ± 4.8
Karydis et al., 2004GreeceCross sectionalClinical data1573.3NR
Kattamis et al., 1970GreeceCross sectionalClinical data7452.7Less than 11
Kwan et al., 1995ChinaCross sectionalClinical data6848.511.3 ± 3.8
Lau et al., 1998ChinaCross sectionalClinical data1258.311.4
Li et al., 2004ChinaCross sectionalClinical data3253.19.2 ± 4.5
Low et al., 1995ChinaCross sectionalClinical data15NRNR
Low et al., 1997ChinaCross sectionalClinical data41NRNR
Madeddu et al., 1978ItalyCase controlClinical data50462–13
Mahachoklertwattana et al., 2011ThailandCross sectionalClinical data20NR11.7
Masala et al., 2003ItalyCross sectionalClinical data and medical records28346.95-12
Mettananda et al., 2019Sri LankaCase controlClinical data22449.110.9 ± 3.6
Mirhosseini et al., 2012IranCross sectionalClinical data14056.48–18
Mirhosseini et al., 2013IranCross sectionalClinical data14056.48–18
Moayeri et al., 2006IranCross sectionalClinical data15848.115.1 ± 4.8
Mohseni et al., 2014IranCross sectionalClinical data3046.65–19
Mousa et al., 2016EgyptCross sectionalClinical data3857.823
Nabavizadeh et al., 2007IranCross sectionalClinical data12150.4NR
Najafpour et al., 2008IranCross sectionalMedical records5664.215.62 ± 4.44
Ozkan et al., 2001TurkeyCross sectionalClinical data20401–14
Perera et al., 2010Australiaretrospective cohortClinical data2934.429
Poggi et al., 2010ItalyCross sectionalClinical data2853.530 ± 6.2
Roth et al., 1997GermanyCross sectionalClinical data3259.33 ± 36
Safarinejad et al., 2008IranCase controlClinical data16810024 ± 4.6
Safarinejad et al., 2010IranCase controlClinical data106016.4 ± 2.2
Saffari et al., 2012IranCross-sectionalClinical data7751.921.26 ± 4.53
Saka et al., 1995TurkeyCross sectionalClinical data5446.210.4
Shah et al., 2019PakistanCross sectionalClinical data1005313.62 ± 3.78
Shalitin et al., 2005IsraelCross sectionalMedical records3953.816.3
Shamshirsaz et al., 2003Irancross-sectionalquestionnaires22051.515.2 ± 3.1
Sharma et al., 2016IndiaProspectiveClinical data8957.313.6
Soliman et al., 2009QatarCohortClinical data272NR13–21
Soliman et al., 2011QatarCross sectionalNR26NR9.5 ± 4.2
Vidergor et al., 2007IsraelCase controlMedical records1643.7NR
Vichinsky et al., 2005USACross sectionalMedical records3046.68.7
Vogiatzi et al., 2009North AmericaCross sectionalClinical data Medical records236NR6.1–75.4
Wu et al., 2003Taiwancross sectionalClinical data2955.111.2 ± 4.3
Yaman et al., 2013TurkeyRetrospectiveClinical data5657.12–20
Yassin et al., 2018QatarCross sectionalClinical data52NRNR
Yin et al., 2011ChinaCross sectionalMedical records231NR5
Table 2

The pooled prevalence of endocrine complications in β-thalassemia transfusion-dependent patient.

COMPLICATIONSTUDIES (N)SAMPLE SIZE (N)PREVALENCE (%)95% CIP-VALUEI2 (%)
STGenderFemale731650.941.8–59.90.85071.33
Male741561.953.4–69.70.00639.39
RegionAfrica213868.147.8–83.20.07900.00
Asia35312849.244–54.40.77385.74
Europe956636.327.3–46.40.00874.46
Overall46383248.935.3–62.60.87386.69
GRGenderFemale641433.19.4–70.20.37796.02
Male629251.617.8–840.93894.81
RegionAfrica128579.1–94.60.83100.00
America130272.7–83.30.45400.00
Asia12101542.125.5–60.70.41095.02
Europe3331639.312.7–74.20.56698.37
Oceania129353.9–87.80.63900.00
Overall18441841.127.5–56.40.25395.39
GHRegionAfrica24634.18.9–73.20.43800.00
Asia88552714–45.50.01792.36
Europe3320021.66.8–50.90.05797.96
Overall13410126.616–40.80.00298.11
Figure 2

Forrest plot of the pooled prevalence of ST in B-thalassemia transfusion-dependent patients.

Figure 3

Forrest plot of the pooled prevalence of ST subgrouped by gender in B-thalassemia transfusion-dependent patients.

Figure 4

Forrest plot of the pooled prevalence of GR in B-thalassemia transfusion-dependent patients.

Figure 5

Forrest plot of the pooled prevalence of GR sub-grouped by gender in B-thalassemia transfusion-dependent patients.

Figure 6

Forrest plot of the pooled prevalence of GH in B-thalassemia transfusion-dependent patients.

DOI: https://doi.org/10.5334/aogh.3184 | Journal eISSN: 2214-9996
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Language: English
Published on: Jun 8, 2021
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2021 Morteza Arab-Zozani, Setare Kheyrandish, Amirhossein Rastgar, Ebrahim Miri-Moghadam, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

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