The Risk of Orofacial Cleft Lip/Palate Due to Maternal Ambient Air Pollution Exposure: A Call for Further Research in South Africa

Caradee Y. Wright; Thandi Kapwata; Bianca Wernecke; Helen Malherbe; Kurt-W Bütow; Natasha Naidoo; Rebecca M. Garland; Anzel de Lange; Gareth E. Murray; Operation Smile

doi:10.5334/aogh.4007

The Risk of Orofacial Cleft Lip/Palate Due to Maternal Ambient Air Pollution Exposure: A Call for Further Research in South Africa

Volume 89 (2023): Issue 1

By: Caradee Y. Wright , Thandi Kapwata , Bianca Wernecke , Helen Malherbe , Kurt-W Bütow , Natasha Naidoo , Rebecca M. Garland , Anzel de Lange , Gareth E. Murray and Operation Smile

Open Access

|Jan 2023

Jensen SWC, Jensen ED, Kaminer-Levin G, Caro C, Stevens K. Presurgical cleft management of infants: A survey of ACPA approved and international cleft palate and craniofacial teams. Cleft Palate-Craniofacial J. Published online 2022; 10556656221109416. DOI: 10.1177/10556656221109416
Open DOI Search in Google Scholar Back to article
Salari N, Darvishi N, Heydari M, Bokaee S, Darvishi F, Mohammadi M. Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis. J Stomatol oral Maxillofac Surg. 2022; 123(2): 110–120. DOI: 10.1016/j.jormas.2021.05.008
Open DOI Search in Google Scholar Back to article
Hlongwa P, Dandajena TC, Rispel LC. Comparative analysis of healthcare provision to individuals with cleft lip and/or palate at specialised academic centres in South Africa. S Afr Med J. 2019; 109(6): 426–430. DOI: 10.7196/SAMJ.2019.v109i6.13654
Open DOI Search in Google Scholar Back to article
Canfield MA, Honein MA, Yuskiv N, et al. National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999–2001. Birth Defects Res A Clin Mol Teratol. 2006; 76(11): 747–756. DOI: 10.1002/bdra.20294
Open DOI Search in Google Scholar Back to article
Goenjian HA, Chiu ES, Alexander ME, St Hilaire H, Moses M. Incidence of cleft pathology in Greater New Orleans before and after Hurricane Katrina. Cleft palate-craniofacial J Off Publ Am Cleft Palate-Craniofacial Assoc. 2011; 48(6): 757–761. DOI: 10.1597/09-246
Open DOI Search in Google Scholar Back to article
do Rego Borges A, Sá J, Hoshi R, et al. Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Brazilian population with high African ancestry. Am J Med Genet A. 2015; 167A(10): 2344–2349. DOI: 10.1002/ajmg.a.37181
Open DOI Search in Google Scholar Back to article
Gowans LJJ, Oseni G, Mossey PA, et al. Novel GREM1 variations in sub-Saharan African patients with cleft lip and/or cleft palate. Cleft palate-craniofacial J Off Publ Am Cleft Palate-Craniofacial Assoc. 2018; 55(5): 736–742. DOI: 10.1177/1055665618754948
Open DOI Search in Google Scholar Back to article
Li M, Olotu J, Buxo-Martinez CJ, et al. Variant analyses of candidate genes in orofacial clefts in multi-ethnic populations. Oral Dis. 2022; 28(7): 1921–1935. DOI: 10.1111/odi.13932
Open DOI Search in Google Scholar Back to article
Stuppia L, Capogreco M, Marzo G, et al. Genetics of syndromic and nonsyndromic cleft lip and palate. J Craniofac Surg. 2011; 22(5): 1722–1726. DOI: 10.1097/SCS.0b013e31822e5e4d
Open DOI Search in Google Scholar Back to article
Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. Cleft lip and palate. Lancet (London, England). 2009; 374(9703): 1773–1785. DOI: 10.1016/S0140-6736(09)60695-4
Open DOI Search in Google Scholar Back to article
Worley ML, Patel KG, Kilpatrick LA. Cleft lip and palate. Clin Perinatol. 2018; 45(4): 661–678. DOI: 10.1016/j.clp.2018.07.006
Open DOI Search in Google Scholar Back to article
Hopf KP. Mortality and orofacial cleft: A systematic review and meta-analysis; 2020.
Search in Google Scholar Back to article
Impellizzeri A, Giannantoni I, Polimeni A, Barbato E, Galluccio G. Epidemiological characteristic of Orofacial clefts and its associated congenital anomalies: retrospective study. BMC Oral Health. 2019; 19(1): 290. DOI: 10.1186/s12903-019-0980-5
Open DOI Search in Google Scholar Back to article
Carlson LC, Hatcher KW, Tomberg L, Kabetu C, Ayala R, Vander Burg R. Inequitable access to timely cleft palate surgery in low- and middle-income countries. World J Surg. 2016; 40(5): 1047–1052. DOI: 10.1007/s00268-015-3374-0
Open DOI Search in Google Scholar Back to article
Conway JC, Taub PJ, Kling R, Oberoi K, Doucette J, Jabs EW. Ten-year experience of more than 35,000 orofacial clefts in Africa. BMC Pediatr. 2015; 15(8). DOI: 10.1186/s12887-015-0328-5
Open DOI Search in Google Scholar Back to article
Rao A, Ahmed MK, Taub PJ, Mamoun JS. The correlation between maternal exposure to air pollution and the risk of orofacial clefts in infants: A systematic review and meta-analysis. J oral Maxillofac Res. 2016; 7(1): e2. DOI: 10.5037/jomr.2016.7102
Open DOI Search in Google Scholar Back to article
World Health Organisation. WHO global air quality guidelines: particulate matter (PM_2.5 and PM₁₀), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. World Health Organization; 2021.
Search in Google Scholar Back to article
Roy R. The cost of air pollution in Africa. 2016; 333. DOI: 10.1787/5jlqzq77x6f8-en
Open DOI Search in Google Scholar Back to article
Awotoye W, Mossey PA, Hetmanski JB, et al. Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate. Sci Rep. 2022; 12(1): 11743. DOI: 10.1038/s41598-022-15885-1
Open DOI Search in Google Scholar Back to article
Martinelli M, Palmieri A, Carinci F, Scapoli L. Non-syndromic cleft palate: An overview on human genetic and environmental risk factors. Front Cell Dev Biol. 2020; 8. https://www.frontiersin.org/articles/10.3389/fcell.2020.592271. DOI: 10.3389/fcell.2020.592271
Open DOI Search in Google Scholar Back to article
Askarian S, Gholami M, Khalili-Tanha G, et al. The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility. Oral Maxillofac Surg. Published online April 2022. DOI: 10.1007/s10006-022-01052-3
Open DOI Search in Google Scholar Back to article
Padula AM, Yang W, Schultz K, et al. Gene-environment interactions between air pollution and biotransformation enzymes and risk of birth defects. Birth defects Res. 2021; 113(9): 676–686. DOI: 10.1002/bdr2.1880
Open DOI Search in Google Scholar Back to article
Soim A, Sheridan SC, Hwang S-A, et al. A population-based case-control study of the association between weather-related extreme heat events and orofacial clefts. Birth defects Res. 2018; 110(19): 1468–1477. DOI: 10.1002/bdr2.1385
Open DOI Search in Google Scholar Back to article
Haghighi MM, Wright CY, Ayer J, et al. Impacts of high environmental temperatures on congenital anomalies: A systematic review. Int J Environ Res Public Health. 2021; 18(9). DOI: 10.3390/ijerph18094910
Open DOI Search in Google Scholar Back to article
Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S. Maternal cigarette smoking and cleft lip and palate: A systematic review and meta-analysis. Cleft palate-craniofacial J Off Publ Am Cleft Palate-Craniofacial Assoc. 2022; 59(9): 1185–1200. DOI: 10.1177/10556656211040015
Open DOI Search in Google Scholar Back to article
Ahmed Sakran K, Mutahar Abotaleb B, Khaled Al-Rokhami R, et al. Analysis of environmental exposures for nonsyndromic cleft lip and/or palate: A case-control study. Iran J Public Health. 2022; 51(3): 578–586. DOI: 10.18502/ijph.v51i3.8934
Open DOI Search in Google Scholar Back to article
Jia ZL, Shi B, Chen CH, Shi JY, Wu J, Xu X. Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts. Oral Dis. 2011; 17(6): 584–589. DOI: 10.1111/j.1601-0825.2011.01810.x
Open DOI Search in Google Scholar Back to article
Garland MA, Reynolds K, Zhou CJ. Environmental mechanisms of orofacial clefts. Birth defects Res. 2020; 112(19): 1660–1698. DOI: 10.1002/bdr2.1830
Open DOI Search in Google Scholar Back to article
Tanner JP, Salemi JL, Stuart AL, et al. Associations between exposure to ambient benzene and PM_2.5 during pregnancy and the risk of selected birth defects in offspring. Environ Res. 2015; 142: 345–353. DOI: 10.1016/j.envres.2015.07.006
Open DOI Search in Google Scholar Back to article
Girguis MS, Strickland MJ, Hu X, Liu Y, Bartell SM, Vieira VM. Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environ Res. 2016; 146: 1–9. DOI: 10.1016/j.envres.2015.12.010
Open DOI Search in Google Scholar Back to article
Zhou Y, Gilboa SM, Herdt ML, et al. Maternal exposure to ozone and PM_(2.5) and the prevalence of orofacial clefts in four U.S. states. Environ Res. 2017; 153: 35–40. DOI: 10.1016/j.envres.2016.11.007
Open DOI Search in Google Scholar Back to article
Zhu Y, Zhang C, Liu D, Grantz KL, Wallace M, Mendola P. Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects. Environ Res. 2015; 140: 714–720. DOI: 10.1016/j.envres.2015.06.002
Open DOI Search in Google Scholar Back to article
Krajewski AK, Rappazzo KM, Langlois PH, Messer LC, Lobdell DT. Associations between cumulative environmental quality and ten selected birth defects in Texas. Birth defects Res. 2021; 113(2): 161–172. DOI: 10.1002/bdr2.1788
Open DOI Search in Google Scholar Back to article
Bui AH, Ayub A, Ahmed MK, Taioli E, Taub PJ. Maternal tobacco exposure and development of orofacial clefts in the child: A case-control study conducted in Pakistan. Ann Plast Surg. 2018; 81(6): 708–714. DOI: 10.1097/SAP.0000000000001665
Open DOI Search in Google Scholar Back to article
Xu LF, Zhou XL, Wang Q, et al. A case-control study of environmental risk factors for nonsyndromic cleft of the lip and/or palate in Xuzhou, China. Biomed Environ Sci. 2015; 28(7): 535–538. DOI: 10.3967/bes2015.076
Open DOI Search in Google Scholar Back to article
Pi X, Li Z, Jin L, et al. Secondhand smoke during the periconceptional period increases the risk for orofacial clefts in offspring. Paediatr Perinat Epidemiol. 2018; 32(5): 423–427. DOI: 10.1111/ppe.12497
Open DOI Search in Google Scholar Back to article
Liu Y, Wang B, Li Z, Zhang L, Liu J, Ren A. Indoor air pollution and the risk of orofacial clefts in a rural population in Shanxi province, China. Birth Defects Res Part A Clin Mol Teratol. 2016; 106(8): 708–715. DOI: 10.1002/bdra.23522
Open DOI Search in Google Scholar Back to article
Yu G, Chen Y, Tang J, et al. Meta-analyses of maternal exposure to atmospheric particulate matter and risk of congenital anomalies in offspring. Environ Sci Pollut Res Int. 2021; 28(40): 55869–55887. DOI: 10.1007/s11356-021-16200-7
Open DOI Search in Google Scholar Back to article
Wallis RS, Kim P, Cole S, et al. Tuberculosis biomarkers discovery: Developments, needs, and challenges. Lancet Infect Dis. 2013; 13(4): 362–372. DOI: 10.1016/S1473-3099(13)70034-3
Open DOI Search in Google Scholar Back to article
Enebish T, Franklin M, Habre R, et al. Acute temporal effect of ambient air pollution on common congenital cardiovascular defects and cleft palate: a case-crossover study. medRxiv. Published online 2022. DOI: 10.1101/2022.03.06.22271984
Open DOI Search in Google Scholar Back to article
Gasca-Sanchez FM, Santos-Guzman J, Elizondo-Dueñaz R, et al. Spatial clusters of children with cleft lip and palate and their association with polluted zones in the Monterrey metropolitan area. Int J Environ Res Public Health. 2019; 16(14). DOI: 10.3390/ijerph16142488
Open DOI Search in Google Scholar Back to article
Egbunah UP, Adekunle AA, Adeyemo WL. Knowledge of environmental and genetic risk factors for cleft lip and palate among dwellers of a suburban community in Nigeria. West Afr J Med. 2022; 39(5): 478–485. DOI: 10.55891/wajm.v39i5.120
Open DOI Search in Google Scholar Back to article
Mbuyi-musanzayi S, Kayembe TJ, Kashal MK, et al. Non-syndromic cleft lip and/or cleft palate: Epidemiology and risk factors in Lubumbashi (DR Congo), a case-control study. J Cranio-Maxillofacial Surg. 2018; 46(7): 1051–1058. DOI: 10.1016/j.jcms.2018.05.006
Open DOI Search in Google Scholar Back to article
Auslander A, Mckean-Cowdin R, Brindopke F, Magee K, DiBona M, Magee W. Environmental risk factors for cleft lip and palate in low-resource settings: a case-control study. Lancet Glob Heal. 2019; 7: S19. DOI: 10.1016/S2214-109X(19)30104-4
Open DOI Search in Google Scholar Back to article
Arowosegbe OO, Röösli M, Künzli N, et al. Ensemble averaging using remote sensing data to model spatiotemporal PM₍₁₀₎ concentrations in sparsely monitored South Africa. Environ Pollut. 2022; 310: 119883. DOI: 10.1016/j.envpol.2022.119883
Open DOI Search in Google Scholar Back to article
Air pollution and health—A science-policy initiative. Ann Glob Heal. 2019; 85(1): 140. DOI: 10.5334/aogh.2656
Open DOI Search in Google Scholar Back to article
StataCorp. Stata statistical software: Release 15. Coll Station TX StataCorp LLC. Published online 2017.
Search in Google Scholar Back to article
South African Government. National environmental management: Air quality act: Highveld priority area air management plan; 2012. www.gov.za.
Search in Google Scholar Back to article
South African Government. National environmental management: Air quality act: Declaration of Vaal Triangle air-shed priority area; 2006. www.gov.za.
Search in Google Scholar Back to article
Feig G, Garland RM, Naidoo S, Maluleke A, Van der Merwe M. Assessment of changes in concentrations of selected criteria pollutants in the Vaal and Highveld priority areas. Clean Air J. 2019; 29(2 SE-Research Article). DOI: 10.17159/caj/2019/29/2.7464
Open DOI Search in Google Scholar Back to article
Govender K, Sivakumar V. A decadal analysis of particulate matter (PM_2.5) and surface ozone (O₃) over Vaal priority area, South Africa. Clean Air J. 2019; 29(2 SE-Research Article). DOI: 10.17159/caj/2019/29/2.7578
Open DOI Search in Google Scholar Back to article
Sun R, Zhou Y, Wu J, Gong Z. Influencing factors of PM_(2.5) pollution: Disaster points of meteorological factors. Int J Environ Res Public Health. 2019; 16(20). DOI: 10.3390/ijerph16203891
Open DOI Search in Google Scholar Back to article
Tularam H, Ramsay LF, Muttoo S, et al. Harbor and intra-city drivers of air pollution: Findings from a land use regression model, Durban, South Africa. Int J Environ Res Public Health. 2020; 17(15). DOI: 10.3390/ijerph17155406
Open DOI Search in Google Scholar Back to article
Saenen ND, Plusquin M, Bijnens E, et al. In utero fine particle air pollution and placental expression of genes in the brain-derived neurotrophic factor signaling pathway: An ENVIRONAGE birth cohort study. Environ Health Perspect. 2015; 123(8): 834–840. DOI: 10.1289/ehp.1408549
Open DOI Search in Google Scholar Back to article
Więckowska B, Materna-Kiryluk A, Wiśniewska K, Kossowski T, Latos-Bieleńska A. The detection of areas in Poland with an increased prevalence of isolated cleft lip with or without cleft palate. Ann Agric Environ Med. 2015; 22(1): 110–117. DOI: 10.5604/12321966.1141379
Open DOI Search in Google Scholar Back to article
McKenzie LM, Guo R, Witter RZ, Savitz DA, Newman LS, Adgate JL. Birth outcomes and maternal residential proximity to natural gas development in rural Colorado. Environ Health Perspect. 2014; 122(4): 412–417. DOI: 10.1289/ehp.1306722
Open DOI Search in Google Scholar Back to article
Levy JI, Clougherty JE, Baxter LK, Houseman EA, Paciorek CJ. Evaluating heterogeneity in indoor and outdoor air pollution using land-use regression and constrained factor analysis. Res Rep Health Eff Inst. 2010; (152): 5–91.
Search in Google Scholar Back to article

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DOI: https://doi.org/10.5334/aogh.4007 | Journal eISSN: 2214-9996

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Language: English

Submitted on: Nov 3, 2022

Accepted on: Dec 29, 2022

Published on: Jan 27, 2023

Published by: Ubiquity Press

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

air pollution,

congenital disorder,

birth defect,

orofacial cleft lip/palate,

craniofacial anomalies,

environmental health,

particulate matter

© 2023 Caradee Y. Wright, Thandi Kapwata, Bianca Wernecke, Helen Malherbe, Kurt-W Bütow, Natasha Naidoo, Rebecca M. Garland, Anzel de Lange, Gareth E. Murray, Operation Smile, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 89 (2023): Issue 1