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Figures & Tables

Table 1

Temporal trends in country burden of AF detected by AF screening.

CountryPrevalence
2001–2010 publications*2011–2020 publications*
CohortBurdenCohortBurden
Belgium [225]≥40 years2.2%
(1.3%–3.0% 95% CI)
China [226, 227]General population0.65% (0.66% men, 0.63% women)General population1.14% unadjusted.
0.71% age adjusted (0.72% men, 0.70% women)
34% newly detected AF
England [228, 229]≥65 years8.9% (7.9% to 9.7%) control;
8.4% (7.6% to 9.4%) opportunistic arm;
8.4% (7.6% to 9.3%) systematic arm.
≥45 years2.0% over all
(2.4% men; 1.6% in women)
8% ≥75 years.
≈29.5% newly detected AF
Germany [230]2.5% age weighted.
0.7% 35–44 years
10.6% 65–74 years.
15.5% newly detected AF
Hong Kong [28]General population1.8% overall.
(95% CI 1.6% to 2%)
2.8% men (95% CI 2.3% to 3.3%)
1.4%. women
(95% CI 1.2% to 1.6%).
42.2% newly detected AF
India [25, 26, 27]General population0.1–0.5%General population1.6%
5.6% (for ≥75years.)
Italy [231, 232]≥65 years7.4%≥65 years7.3% overall
(95% CI 6.6–8.1)
8.6% men.
(95% CI 7.5–9.8)
6.2% women
(95% CI 5.3–7.2)
16.7% >85years.
8.1% 2016 population adjustment
(95% CI 5.9–11.1)
Netherlands [9]≥55 years5.5% overall
(0.7% for 55–59 years;
17.8% ≥85years)
Portugal [233, 234]≥40 years2.5% over all
(2.2–2.8%: 95% CI)
6.6% (70 –79 years)
10.4% (≥80years)
≥65 years9% overall
(8.9% men; 9.1% women)
35.9% newly detected
Spain [235, 236]25–74 years0.7%
1.1% men.
0.3% women
≥40 years4.4% (3.8–5.1 95% CI)
4.4% men
(3.6–5.2 95% CI)
4.5% women
(3.6–5.3 95% CI)
17.7% ≥80 years
(14.1–21.3 95% CI)
10% newly detected AF
Sweden [237, 238]General population2.5% overall
2.8% in men
2.1% women
3.9 ≥35 years
6.3% ≥50 years
13.8% ≥80 years
75/76-year-old14.3%.
(95% CI 12.1–16.8)
5.2% newly detected AF (3.8–7.7 95% CI)
Ghana [239]Rural≥50 years0.3% overall
(95% CI 0.1–1.0)
Tanzania [240]Rural≥70 years0.67% overall
(95% CI 0.33–1.01)
0.96% women
(95% CI 0.42 – 1.49
0.31% men
(95% CI 0.04 – 1.24)
Ethiopia [241]Urban≥40 years4.3% overall

[i] Legend: * Publication date may be somewhat later than date of cohort data collection.

Table 2

Main risk factors for incident AF.

Demographic and socioeconomic factors [242, 243, 244, 245, 246, 247, 248]Age, male sex, Caucasian ethnicity, lower socioeconomic status and social deprivation, family history of AF
Lifestyle [242, 243, 244, 249, 250, 251]Smoking/tobacco use, alcohol intake, sedentary lifestyle, or vigorous exercise
Cardiovascular conditions [51, 242, 243, 244, 252, 253, 254, 255, 256, 257]Heart failure, coronary artery disease, vascular disease, rheumatic heart disease and valvular disease, congenital heart disease, heart rhythm disorders
Health factors and other risk factors [242, 243, 244, 258, 259, 260, 261, 262, 263]Hypertension, dyslipidemia, diabetes mellitus, renal dysfunction, obesity, sleep-disordered breathing, chronic obstructive pulmonary disease, inflammatory diseases, surgery
Figure 1

Ideal AF pathway © World Heart Federation.

Table 3

Roadblocks, strategies, and potential solutions.

DimensionRoadblockStrategyPotential solutions
Geographic accessibilityLong distances to clinics result in low numbers of rural patients presenting to clinics for screening and follow-up appointments.
  1. Improve accessibility of screening for rural populations.

  2. Strengthen capacity for ECG testing in remote areas.

  3. Promote the use of digital technology to improve screening and diagnosis of AF.

  1. Train community health workers or pharmacists to screen for possible AF with pulse-checking in non-clinic settings. Educate in schools about checking pulse and relationship of AF with stroke.

    Educate at-risk populations (e.g., those 65+ years of age) to self-screen with pulse checks.

  2. Implement novel telemedicine technologies (e.g., transmission of ECG results from rural areas to urban facilities) including handheld digital rhythm strips (accepted by ESC for AF diagnosis).

  3. Use digital technology or ‘wearables’ to conduct non-invasive screening (e.g., PPG readings generated from smartphones, though ECG still required for diagnosis).

  4. Use digital technology for remote patient follow up (e.g., phone or video calls).

AvailabilityShortage of health care professionals with training in AF, including interpretation of ECG, initiation of and monitoring of anticoagulation therapy.
Absence of rhythm-control strategies
Lack of integration of AF management services with other cardiology and medical care.
  1. Raise awareness of AF among health care professionals.

  2. Reduce dependence on highly trained medical staff for AF screening and management.

  3. Implement coherent rhythm control strategies.

  4. Better integration with other cardiology and medical services.

  1. Conduct awareness campaigns through healthcare professional networks.

  2. Improve postgraduate training and CME.

  3. Develop simple and locally applicable AF guidelines.

  4. Implement non-physician healthcare workers (NPHW)-managed anticoagulation program.

  5. Increase governmental funding.

  6. Progress towards Universal Health Coverage (UHC).

  7. Train human resources.

  8. Set up AF research and registries in LMICs to ascertain the disease patterns specific to these countries.

  9. Involve allied health professionals for monitoring and follow-up purposes.

  10. Rely on electronic solutions (e.g., smartphones and apps) to provide patients with regular guidance.

  11. Promote awareness of AF management in related medical services (hypertension, heart failure, coronary artery disease, medical).

  12. Treat and prevent contributory factors (e.g., hypertension, heart failure, coronary artery disease).

AffordabilityOACs potentially unaffordable for patient households, resulting in nonadherence to treatment regime. Pharmaceutical poverty.
Access to non-pharmacological rhythm control strategies, i.e., catheter ablation, LAAO.
  1. Improve affordability of OACs and other essential medicines so that every patient can access them.

  2. Design novel treatment environments such as office-based labs.

  1. Provide universal health care coverage for essential medicines, or provide similar support via a not-for-profit organisation).

  2. Implement internationally recognized policies for the reduction of essential medicine costs.

  3. Ensure that national essential medicines lists include NOACs.

  4. Promote the availability of NOACs as generics.

  5. Office-based labs provide safe and affordable spaces for interventions in AF patients.

AcceptabilityReluctance of physicians and patients to initiate anticoagulation therapy.
Lack of awareness of importance of persistent adherence to OAC therapy.
  1. Improve awareness of and capacity for managing OAC. therapy among physicians.

  2. Improve patient understanding of importance of OAC therapy and capacity to adhere to therapy.

  1. Conduct country-specific training on OAC therapy management and support programmes for non-cardiologist health care professionals with the support of professional patient organisations when available.

  2. Develop and implement country-specific patient education, health literacy, and support programmes for diagnosed AF patients on OAC therapy and foster the dissemination of existing resources across countries.

  3. Support the development of structured patient organisations.

  4. Foster patient-centred approaches to support medication adherence and effective lifestyle risk reduction.

  5. Foster patient self-management and adherence to medication through digital technology and connected devices.

  6. Conduct research into feasibility of self-monitoring programmes for patients on OAC therapy in LMICs.

QualityUnavailability of standards or norms to ascertain the quality of certain new devices, services, and treatments.
Lack of patient-reported outcomes.
Lack of a clear definition of quality indicators and markers, including specificities per regions.
Implement robust mechanisms for the accreditation/certification of new devices, services, and treatments.
Rely on a set of standardised patient report outcomes.
Adopt a globally acceptable definition of quality indicators and markers.
  1. Create a list of certified devices, apps, etc.

  2. Ensure that technology is supported by a clear pathway to treatment.

  3. Foster implementation research.

  4. Promote the use of a standard set of patient-reported outcomes among health practitioners (195).

  5. Use a common definition of quality indicators and markers.

Figure 2

Recording of ECG rhythm strip by a woman instructed by a village health worker using a mobile hand-held smartphone ECG device. Reprinted from International Journal of Cardiology, 280, Soni A, Karna S, Fahey N, Sanghai S, Patel H, Raithatha S, et al., Age-and-sex Stratified Prevalence of Atrial Fibrillation in Rural Western India: Results of SMARTIndia, a population-based screening study, pp. 84–88, 2019, with permission from Elsevier.

Figure 3

Proposed hub-and-spoke model of oral anticoagulant therapy in patients with atrial fibrillation in low- and middle-income countries. Specialist doctor at hub – If no specialist is available, the hub may be a GP. GP – general practitioner, HW – health worker at spoke. P – the depicted Patient (P) here has point-of-care INR monitoring facility and dosage adjustment and data sharing app.

Table 4

Educational items for anticoagulant medication adherence to be delivered by physicians or other health professionals to patients with atrial fibrillation.

Important patient instructions
  • A non-vitamin K antagonist anticoagulant (NOAC) thins the blood and reduces the risk of getting dangerous blood clots, in the same way as vitamin K antagonists (VKA, e.g., warfarin).

  • Not taking the drug means no protection!

  • Take your drug exactly as prescribed (once or twice daily for NOAC, once a day with the correct dose for VKA).

  • Do not skip a prescribed dose to ensure optimal protection from blood clots and stroke!

  • Do not stop your medication without consulting your physician.

For NOACs, you may need occasional creatinine blood tests to check kidney function
For VKA, ensure a stable diet of vitamin K containing foods, and have your INR checked regularly to make sure you have optimal anticoagulation protection against clots without increasing bleeding risk.
  • After a trauma or bleeding event, consult with your physician regarding further management

  • Do not add any other medication without consulting your physician, not even short-term painkillers that you can get without a prescription. You may need INR testing after starting any new medication if you are taking VKA

  • Alert your dentist, surgeon, or another physician before an intervention.

What to do in certain occasions
When should I contact a healthcare provider?
Bleeding is the most common side effect of an anticoagulant. However, the reduction in the risk for stroke outweighs the bleeding risk. Contact your healthcare provider if you have any signs or symptoms of bleeding such as:
  • Unusual bruising, nosebleeds, bleeding of gums, bleeding from cuts that take a long time to stop

  • Menstrual flow or vaginal bleeding that is heavier than normal

  • Blood in urine, red or black stools

  • Coughing up blood or vomiting blood

  • Dizziness, paleness, or weakness

What should I do if I missed a dose of NOAC?
You should still take that dose unless the time until your next dose is less than the time after your missed dose.
What if I accidentally took two doses of NOAC?
  • Twice daily NOAC: you can opt to forgo the next planned dose and restart after 24 h.

  • Once daily NOAC: you can continue the normal regimen without skipping a dose.

What if I missed a dose of VKA or accidentally took an extra dose?
Continue your normal dosing if you missed a dose. Omit one dose and have an INR check if you took a double dose

[i] * This table is adapted from the 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation [264].

Figure 4

Key educational points to convey to the patients with atrial fibrillation at each visit by physicians. © World Heart Federation. Adapted based on the 2018 European Heart Rhythm Association Practical Guide recommendations [264].

DOI: https://doi.org/10.5334/gh.1023 | Journal eISSN: 2211-8179
Language: English
Submitted on: Mar 3, 2021
Accepted on: May 6, 2021
Published on: May 27, 2021
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2021 Ben Freedman, Gerhard Hindricks, Amitava Banerjee, Adrian Baranchuk, Chi Keong Ching, Xin Du, Donna Fitzsimons, Jeff S. Healey, Takanori Ikeda, Trudie C. A. Lobban, Amam Mbakwem, Calambur Narasimhan, Lis Neubeck, Peter Noseworthy, Daniel M. Philbin, Fausto J. Pinto, Joselyn Rwebembera, Renate B. Schnabel, Jesper Hastrup Svendsen, Luis Aguinaga, Elena Arbelo, Michael Böhm, Hasan Ali Farhan, F. D. Richard Hobbs, Antoni Martínez-Rubio, Claudio Militello, Nitish Naik, Jean Jacques Noubiap, Pablo Perel, Daniel José Piñero, Antonio Luiz Ribeiro, Janina Stepinska, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.