Table 1
Temporal trends in country burden of AF detected by AF screening.
| Country | Prevalence | |||
|---|---|---|---|---|
| 2001–2010 publications* | 2011–2020 publications* | |||
| Cohort | Burden | Cohort | Burden | |
| Belgium [225] | ≥40 years | 2.2% (1.3%–3.0% 95% CI) | ||
| China [226, 227] | General population | 0.65% (0.66% men, 0.63% women) | General population | 1.14% unadjusted. 0.71% age adjusted (0.72% men, 0.70% women) 34% newly detected AF |
| England [228, 229] | ≥65 years | 8.9% (7.9% to 9.7%) control; 8.4% (7.6% to 9.4%) opportunistic arm; 8.4% (7.6% to 9.3%) systematic arm. | ≥45 years | 2.0% over all (2.4% men; 1.6% in women) 8% ≥75 years. ≈29.5% newly detected AF |
| Germany [230] | 2.5% age weighted. 0.7% 35–44 years 10.6% 65–74 years. 15.5% newly detected AF | |||
| Hong Kong [28] | General population | 1.8% overall. (95% CI 1.6% to 2%) 2.8% men (95% CI 2.3% to 3.3%) 1.4%. women (95% CI 1.2% to 1.6%). 42.2% newly detected AF | ||
| India [25, 26, 27] | General population | 0.1–0.5% | General population | 1.6% 5.6% (for ≥75years.) |
| Italy [231, 232] | ≥65 years | 7.4% | ≥65 years | 7.3% overall (95% CI 6.6–8.1) 8.6% men. (95% CI 7.5–9.8) 6.2% women (95% CI 5.3–7.2) 16.7% >85years. 8.1% 2016 population adjustment (95% CI 5.9–11.1) |
| Netherlands [9] | ≥55 years | 5.5% overall (0.7% for 55–59 years; 17.8% ≥85years) | ||
| Portugal [233, 234] | ≥40 years | 2.5% over all (2.2–2.8%: 95% CI) 6.6% (70 –79 years) 10.4% (≥80years) | ≥65 years | 9% overall (8.9% men; 9.1% women) 35.9% newly detected |
| Spain [235, 236] | 25–74 years | 0.7% 1.1% men. 0.3% women | ≥40 years | 4.4% (3.8–5.1 95% CI) 4.4% men (3.6–5.2 95% CI) 4.5% women (3.6–5.3 95% CI) 17.7% ≥80 years (14.1–21.3 95% CI) 10% newly detected AF |
| Sweden [237, 238] | General population | 2.5% overall 2.8% in men 2.1% women 3.9 ≥35 years 6.3% ≥50 years 13.8% ≥80 years | 75/76-year-old | 14.3%. (95% CI 12.1–16.8) 5.2% newly detected AF (3.8–7.7 95% CI) |
| Ghana [239] | Rural | ≥50 years | 0.3% overall (95% CI 0.1–1.0) | |
| Tanzania [240] | Rural | ≥70 years | 0.67% overall (95% CI 0.33–1.01) 0.96% women (95% CI 0.42 – 1.49 0.31% men (95% CI 0.04 – 1.24) | |
| Ethiopia [241] | Urban | ≥40 years | 4.3% overall | |
[i] Legend: * Publication date may be somewhat later than date of cohort data collection.
Table 2
Main risk factors for incident AF.
| Demographic and socioeconomic factors [242, 243, 244, 245, 246, 247, 248] | Age, male sex, Caucasian ethnicity, lower socioeconomic status and social deprivation, family history of AF |
| Lifestyle [242, 243, 244, 249, 250, 251] | Smoking/tobacco use, alcohol intake, sedentary lifestyle, or vigorous exercise |
| Cardiovascular conditions [51, 242, 243, 244, 252, 253, 254, 255, 256, 257] | Heart failure, coronary artery disease, vascular disease, rheumatic heart disease and valvular disease, congenital heart disease, heart rhythm disorders |
| Health factors and other risk factors [242, 243, 244, 258, 259, 260, 261, 262, 263] | Hypertension, dyslipidemia, diabetes mellitus, renal dysfunction, obesity, sleep-disordered breathing, chronic obstructive pulmonary disease, inflammatory diseases, surgery |

Figure 1
Ideal AF pathway © World Heart Federation.
Table 3
Roadblocks, strategies, and potential solutions.
| Dimension | Roadblock | Strategy | Potential solutions |
|---|---|---|---|
| Geographic accessibility | Long distances to clinics result in low numbers of rural patients presenting to clinics for screening and follow-up appointments. |
|
|
| Availability | Shortage of health care professionals with training in AF, including interpretation of ECG, initiation of and monitoring of anticoagulation therapy. Absence of rhythm-control strategies Lack of integration of AF management services with other cardiology and medical care. |
|
|
| Affordability | OACs potentially unaffordable for patient households, resulting in nonadherence to treatment regime. Pharmaceutical poverty. Access to non-pharmacological rhythm control strategies, i.e., catheter ablation, LAAO. |
|
|
| Acceptability | Reluctance of physicians and patients to initiate anticoagulation therapy. Lack of awareness of importance of persistent adherence to OAC therapy. |
|
|
| Quality | Unavailability of standards or norms to ascertain the quality of certain new devices, services, and treatments. Lack of patient-reported outcomes. Lack of a clear definition of quality indicators and markers, including specificities per regions. | Implement robust mechanisms for the accreditation/certification of new devices, services, and treatments. Rely on a set of standardised patient report outcomes. Adopt a globally acceptable definition of quality indicators and markers. |
|

Figure 2
Recording of ECG rhythm strip by a woman instructed by a village health worker using a mobile hand-held smartphone ECG device. Reprinted from International Journal of Cardiology, 280, Soni A, Karna S, Fahey N, Sanghai S, Patel H, Raithatha S, et al., Age-and-sex Stratified Prevalence of Atrial Fibrillation in Rural Western India: Results of SMARTIndia, a population-based screening study, pp. 84–88, 2019, with permission from Elsevier.

Figure 3
Proposed hub-and-spoke model of oral anticoagulant therapy in patients with atrial fibrillation in low- and middle-income countries. Specialist doctor at hub – If no specialist is available, the hub may be a GP. GP – general practitioner, HW – health worker at spoke. P – the depicted Patient (P) here has point-of-care INR monitoring facility and dosage adjustment and data sharing app.
Table 4
Educational items for anticoagulant medication adherence to be delivered by physicians or other health professionals to patients with atrial fibrillation.
| Important patient instructions |
|
| For NOACs, you may need occasional creatinine blood tests to check kidney function |
| For VKA, ensure a stable diet of vitamin K containing foods, and have your INR checked regularly to make sure you have optimal anticoagulation protection against clots without increasing bleeding risk. |
|
| What to do in certain occasions |
| When should I contact a healthcare provider? |
| Bleeding is the most common side effect of an anticoagulant. However, the reduction in the risk for stroke outweighs the bleeding risk. Contact your healthcare provider if you have any signs or symptoms of bleeding such as: |
|
| What should I do if I missed a dose of NOAC? |
| You should still take that dose unless the time until your next dose is less than the time after your missed dose. |
| What if I accidentally took two doses of NOAC? |
|
| What if I missed a dose of VKA or accidentally took an extra dose? |
| Continue your normal dosing if you missed a dose. Omit one dose and have an INR check if you took a double dose |
[i] * This table is adapted from the 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation [264].

Figure 4
Key educational points to convey to the patients with atrial fibrillation at each visit by physicians. © World Heart Federation. Adapted based on the 2018 European Heart Rhythm Association Practical Guide recommendations [264].
