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Cardiac Manifestations in Patients with COVID-19: A Scoping Review Cover

Cardiac Manifestations in Patients with COVID-19: A Scoping Review

Open Access
|Jan 2022

References

  1. World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard: World Health Organization; 2021. Retrieved from: https://covid19.who.int/.
  2. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 72733. DOI: 10.1056/NEJMoa2001017
  3. Lai CC, Liu YH, Wang CY, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths. J Microbiol Immunol Infect. 2020; 53(3): 40412. DOI: 10.1016/j.jmii.2020.02.012
  4. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 Long-term effects of COVID-19: A systematic review and meta-analysis. medRxiv; 2021. DOI: 10.21203/rs.3.rs-266574/v1
  5. Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020; 17(5): 25960. DOI: 10.1038/s41569-020-0360-5
  6. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497506. DOI: 10.1016/S0140-6736(20)30183-5
  7. Driggin E, Madhavan Mahesh V, Bikdeli B, et al. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. Journal of the American College of Cardiology. 2020; 75(18): 235271. DOI: 10.1016/j.jacc.2020.03.031
  8. Lala A, Johnson Kipp W, Januzzi James L, et al. Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection. Journal of the American College of Cardiology. 2020; 76(5): 53346. DOI: 10.1016/j.jacc.2020.06.007
  9. Long B, Brady WJ, Koyfman A, Gottlieb M. Cardiovascular complications in COVID-19. American Journal of Emergency Medicine. 2020; 38(7): 15047. DOI: 10.1016/j.ajem.2020.04.048
  10. Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: A model-based analysis. Lancet Infect Dis. 2020; 20(6): 66977. DOI: 10.1016/S1473-3099(20)30243-7
  11. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Jama. 2020; 323(13): 123942. DOI: 10.1001/jama.2020.2648
  12. Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020; 5(7): 80210. DOI: 10.1001/jamacardio.2020.0950
  13. Clerkin KJ, Fried JA, Raikhelkar J, et al. COVID-19 and Cardiovascular Disease. Circulation. 2020; 141(20): 164855. DOI: 10.1161/CIRCULATIONAHA.120.046941
  14. Yahia F, Zakhama L, Ben Abdelaziz A. COVID-19 and Cardiovascular diseases. Scoping review study. Tunis Med. 2020; 98(4): 28394.
  15. Ho JS, Tambyah PA, Ho AF, Chan MY, Sia CH. Effect of coronavirus infection on the human heart: A scoping review. Eur J Prev Cardiol. 2020; 27(11): 113648. DOI: 10.1177/2047487320925965
  16. Arksey H, O’Malley L. Scoping studies: Towards a methodological framework. International Journal of Social Research Methodology. 2005; 8(1): 1932. DOI: 10.1080/1364557032000119616
  17. Levac D, Colquhoun H, O’Brien KK. Scoping studies: Advancing the methodology. Implementation Science. 2010; 5(1): 69. DOI: 10.1186/1748-5908-5-69
  18. Tricco AC, Lillie E, Zarin W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018; 169(7): 46773. DOI: 10.7326/M18-0850
  19. Whiting P, Savović J, Higgins JP, et al. ROBIS: A new tool to assess risk of bias in systematic reviews was developed. J Clin Epidemiol. 2016; 69: 22534. DOI: 10.1016/j.jclinepi.2015.06.005
  20. Singh S, Desai R, Gandhi Z, et al. Takotsubo Syndrome in Patients with COVID-19: A Systematic Review of Published Cases. SN Comprehensive Clinical Medicine; 2020. DOI: 10.1007/s42399-020-00557-w
  21. Pranata R, Huang I, Raharjo SB. Incidence and impact of cardiac arrhythmias in coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. Indian Pacing and Electrophysiology Journal. 2020; 20(5): 1938. DOI: 10.1016/j.ipej.2020.08.001
  22. Hamam O, Goda A, Eldalal M, et al. Cardiac Arrhythmias in Patients with COVID-19: A Systematic review and Meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.10.09.20209379
  23. Momtazmanesh S, Shobeiri P, Hanaei S, et al. Cardiovascular disease in COVID-19: A systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool. Egyptian Heart Journal. 2020; 72(1). DOI: 10.1186/s43044-020-00075-z
  24. Shafi AMA, Shaikh SA, Shirke MM, Iddawela S, Harky A. Cardiac manifestations in COVID-19 patients-A systematic review. J Card Surg. 2020; 35(8): 19882008. DOI: 10.1111/jocs.14808
  25. Hessami A, Shamshirian A, Heydari K, et al. Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis. American Journal of Emergency Medicine; 2020. DOI: 10.1101/2020.04.12.20062869
  26. Thakkar S, Arora S, Kumar A, et al. A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease. medRxiv; 2020. DOI: 10.1177/1179546820977196
  27. Sardinha DM, Batista Lima KV, Lopes Ueno TMR, et al. The occurrence of cardiovascular complications associated with SARS-CoV-2 infection: A systematic review. medRxiv; 2020. DOI: 10.1101/2020.11.14.20231803
  28. Kunutsor SK, Laukkanen JA. Cardiovascular complications in COVID-19: A systematic review and meta-analysis. Journal of Infection. 2020; 81(2): e139e41. DOI: 10.1016/j.jinf.2020.05.068
  29. Malaty M, Kayes T, Amarasekera AT, Kodsi M, MacIntyre CR, Tan TC. Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review. European journal of clinical investigation. 2020; e13428. DOI: 10.1111/eci.13428
  30. Li JW, Han TW, Woodward M, et al. The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis. Progress in Cardiovascular Diseases. 2020; 63(4): 51824. DOI: 10.1016/j.pcad.2020.04.008
  31. Dalia T, Lahan S, Ranka S, et al. Impact of Congestive Heart Failure and Role of Cardiac Biomarkers in COVID-19 patients: A Systematic Review and Meta-Analysis. medRxiv; 2020. DOI: 10.1101/2020.07.06.20147421
  32. Shoar S, Hosseini F, Naderan M, Mehta JL. Meta-analysis of Cardiovascular Events and Related Biomarkers Comparing Survivors Versus Non-survivors in Patients With COVID-19. American Journal of Cardiology; 2020. DOI: 10.1016/j.amjcard.2020.08.044
  33. Martins-Filho PR, Barreto-Filho JAS, Santos VS. Myocardial injury biomarkers and cardiac complications associated with mortality in patients with covid-19. Arquivos Brasileiros de Cardiologia. 2020; 115(2): 2737. DOI: 10.36660/abc.20200372
  34. Li X, Pan X, Li Y, et al. Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: A meta-analysis and systematic review. Critical Care. 2020; 24(1). DOI: 10.1186/s13054-020-03183-z
  35. Michaud V, Dow P, Al Rihani SB, et al. Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugs. medRxiv; 2020. DOI: 10.1101/2020.04.21.20066761
  36. Prodromos CC, Rumschlag T, Perchyk T. Hydroxychloroquine is protective to the heart, not harmful: A systematic review. New Microbes and New Infections. 2020; 37. DOI: 10.1016/j.nmni.2020.100747
  37. Ladapo JA, McKinnon JE, McCullough PA, Risch HA. Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis. medRxiv; 2020. DOI: 10.1101/2020.09.30.20204693
  38. Eljaaly K, Alireza KH, Alshehri S, Al-Tawfiq JA. Hydroxychloroquine safety: A meta-analysis of randomized controlled trials. Travel Medicine and Infectious Disease. 2020; 36: 101812. DOI: 10.1016/j.tmaid.2020.101812
  39. Sitaram K, Pravash B, Dhan Bahadur S, Era R. Research Square; 2021.
  40. Kim MS, An MH, Kim WJ, Hwang T-H. Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis of confounder-adjusted 20212 hospitalized patients. medRxiv; 2020. DOI: 10.1101/2020.06.15.20132407
  41. Takla M, Jeevaratnam K. Chloroquine, hydroxychloroquine, and COVID-19: Systematic review and narrative synthesis of efficacy and safety. medRxiv; 2020. DOI: 10.1101/2020.05.28.20115741
  42. Tleyjeh I, Kashour Z, AlDosary O, et al. The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients: A Systematic Review and Meta-regression Analysis. medRxiv; 2020. DOI: 10.1101/2020.06.16.20132878
  43. Jankelson L, Karam G, Becker ML, Chinitz LA, Tsai MC. QT prolongation, torsades de pointes, and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: A systematic review. Heart Rhythm. 2020; 17(9): 14729. DOI: 10.1016/j.hrthm.2020.05.008
  44. Das RR, Jaiswal N, Dev N, Naik SS, Sankar J. Efficacy and Safety of Anti-malarial Drugs (Chloroquine and Hydroxy-Chloroquine) in Treatment of COVID-19 Infection: A Systematic Review and Meta-Analysis. Frontiers in Medicine. 2020; 7. DOI: 10.3389/fmed.2020.00482
  45. Bavishi C, Bonow RO, Trivedi V, et al. Acute myocardial injury in patients hospitalized with COVID-19 infection: A review. Progress in cardiovascular diseases; 2020. DOI: 10.1016/j.pcad.2020.05.013
  46. Parohan M, Yaghoubi S, Seraji A. Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies. Eur Heart J Acute Cardiovasc Care; 2020. DOI: 10.1177/2048872620937165
  47. Santoso A, Pranata R, Wibowo A, et al. Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis. American Journal of Emergency Medicine; 2020. DOI: 10.1016/j.ajem.2020.04.052
  48. Sawalha K, Abozenah M, Kadado AJ, et al. Systematic review of COVID-19 related myocarditis: Insights on management and outcome. Cardiovascular Revascularization Medicine; 2020. DOI: 10.1016/j.carrev.2020.08.028
  49. Kariyanna PT, Sutarjono B, Grewal E, et al. A Systematic Review of COVID-19 and Myocarditis. Am J Med Case Rep. 2020; 8(9): 299305. DOI: 10.12691/ajmcr-8-9-11
  50. Tian W, Jiang W, Yao J, et al. Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis. Journal of Medical Virology. 2020; 92(10): 187583. DOI: 10.1002/jmv.26050
  51. Walker C, Deb S, Ling H, Wang Z. Assessing the Elevation of Cardiac Biomarkers and the Severity of COVID-19 Infection: A Meta-analysis. Journal of pharmacy & pharmaceutical sciences: A publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2020; 23: 396405. DOI: 10.18433/jpps31501
  52. Parohan M, Yaghoubi S, Seraji A. Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies. European Heart Journal: Acute Cardiovascular Care; 2020. DOI: 10.1177/2048872620937165
  53. Zou F, Qian Z, Wang Y, Zhao Y, Bai J. Cardiac Injury and COVID-19: A Systematic Review and Meta-analysis. CJC Open. 2020; 2(5): 38694. DOI: 10.1007/s10615-010-0267-4
  54. Zeng L, Wang S, Cai J, Sun S, Li J, Sun L. Clinical characteristics of covid-19 with cardiac injury: A systematic review and meta-analysis. Epidemiol Infect. 2020; 124. DOI: 10.1017/S0950268820002587
  55. Pranata R, Huang I, Lukito AA, Raharjo SB. Elevated N-Terminal pro-brain natriuretic peptide is associated with increased mortality in patients with COVID-19: Systematic review and meta-Analysis. Postgraduate Medical Journal. 2020; 96(1137): 38791. DOI: 10.1136/postgradmedj-2020-137884
  56. De Lorenzo A, Kasal D, Tura B, Lamas C, Rey H. Acute cardiac injury in patients with COVID-19. medRxiv; 2020. DOI: 10.1101/2020.05.18.20105866
  57. Prasitlumkum N, Chokesuwattanaskul R, Thongprayoon C, Bathini T, Vallabhajosyula S, Cheungpasitporn W. Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis. Diseases. 2020; 8(4). DOI: 10.3390/diseases8040040
  58. Potere N, Valeriani E, Candeloro M, et al. Acute complications and mortality in hospitalized patients with coronavirus disease 2019: A systematic review and meta-analysis. Critical Care. 2020; 24(1). DOI: 10.1186/s13054-020-03022-1
  59. Zuin M, Rigatelli G, Zuliani G, et al. Incidence and mortality risk in coronavirus disease 2019 patients complicated by acute cardiac injury: Systematic review and meta-analysis. J Cardiovasc Med (Hagerstown). 2020; 21(10): 75964. DOI: 10.2459/JCM.0000000000001064
  60. Gu ZC, Zhang C, Kong LC, et al. Incidence of myocardial injury in coronavirus disease 2019 (COVID-19): A pooled analysis of 7,679 patients from 53 studies. Cardiovascular Diagnosis and Therapy. 2020; 10(4): 66777. DOI: 10.21037/cdt-20-535
  61. Vakili K, Fathi M, Pezeshgi A, et al. Critical complications of COVID-19: A descriptive meta-analysis study. Reviews in cardiovascular medicine. 2020; 21(3): 43342. DOI: 10.31083/j.rcm.2020.03.129
  62. Huang D, Lian X, Song F, et al. Clinical features of severe patients infected with 2019 novel coronavirus: A systematic review and meta-analysis. Annals of Translational Medicine. 2020; 8(9). DOI: 10.21037/atm-20-2124
  63. Luo L, Fu M, Li Y, et al. The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis. Clinical Cardiology; 2020. DOI: 10.1002/clc.23465
  64. Li X, Guan B, Su T, et al. Impact of cardiovascular disease and cardiac injury on in-hospital mortality in patients with COVID-19: A systematic review and meta-analysis. Heart. 2020; 106(15): 11427. DOI: 10.1136/heartjnl-2020-317062
  65. Amir S, Keyvan H, Reza A-N, et al. Cardiovascular Diseases and COVID-19 Mortality and Intensive Care Unit Admission: A Systematic Review and Meta-analysis. medRxiv; 2020.
  66. Hessami A, Shamshirian A, Heydari K, et al. Cardiovascular Diseases Burden in COVID-19: Systematic Review and Meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.04.12.20062869
  67. Asiimwe IG, Pushpakom S, Turner RM, et al. Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.10.07.20208918
  68. Beressa TB, Sahilu T, Deyno S. Effect of Renin-Angiotensin-Aldosterone System inhibitors on outcomes of COVID-19 patients with hypertension: Systematic review and Meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.09.03.20187393
  69. De Almeida-Pititto B, Dualib PM, Zajdenverg L, et al. Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: A meta-analysis. Diabetology and Metabolic Syndrome. 2020; 12(1). DOI: 10.1186/s13098-020-00586-4
  70. Baral R, White M, Vassiliou VS. Impact of hospitalised patients with COVID-19 taking Renin-Angiotensin-Aldosterone System inhibitors: A systematic review and meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.05.03.20089375
  71. Flacco ME, Acuti Martellucci C, Bravi F, et al. Treatment with ACE inhibitors or ARBs and risk of severe/lethal COVID-19: A meta-analysis. Heart. 2020; 106(19): 151924. DOI: 10.1136/heartjnl-2020-317336
  72. Zhang Y, Yu S, Xu Y, Williams B. Renin Angiotensin System Inhibition and Susceptibility and Outcomes from COVID-19: A Systematic Review and Meta-analysis of 69,200 COVID-19 Patients. medRxiv; 2020. DOI: 10.1101/2020.10.03.20206375
  73. Liu X, Long C, Xiong Q, et al. Association of Renin-Angiotensin-Aldosterone System Inhibition with Risk of COVID-19, Inflammation Level Severity and Death in Patients With COVID-19: A Rapid Systematic Review and Meta-Analysis. medRxiv; 2020. DOI: 10.1101/2020.05.20.20108399
  74. Xu J, Teng Y, Shang L, et al. The Effect of Prior ACEI/ARB Treatment on COVID-19 Susceptibility and Outcome: A Systematic Review and Meta-Analysis. Clinical infectious diseases: An official publication of the Infectious Diseases Society of America; 2020.
  75. Ssentongo A, Ssentongo P, Heilbrunn ES, et al. Renin-angiotensin-aldosterone system inhibitors and mortality in patients with hypertension hospitalized for COVID-19: A systematic review and meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.05.21.20107003
  76. Barochiner J, Martinez R. Use of inhibitors of the renin angiotensin system and COVID-19 prognosis: A systematic review and meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.05.19.20106799
  77. Bezabih YM, Bezabih A, Alamneh E, Peterson GM, Bezabhe WM. Comparison of renin-angiotensin-aldosterone system inhibitors with other antihypertensives in association with coronavirus disease-19 clinical outcomes: Systematic review and meta-analysis. medRxiv; 2020. DOI: 10.21203/rs.3.rs-85373/v1
  78. Garg A, Rout A, Sharma A, Fiorello B, Kostis JB. Association of Renin Angiotensin System Blockers with Outcomes in Patients with Covid-19: A Systematic Review and Meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.05.23.20111401
  79. Kaur U, Chakrabarti SS, Patel TK. RAAS blockers and region-specific variations in COVID-19 outcomes: findings from a systematic review and meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.09.09.20191445
  80. Bin Abdulhak AA, Kashour T, Noman A, et al. Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Outcome of COVID-19: A Systematic Review and Meta-analysis. medRxiv; 2020. DOI: 10.1101/2020.05.06.20093260
  81. Pillai P, Joseph JP, Fadzillah NHM, Mahmod M. COVID-19 and Major Organ Thromboembolism: Manifestations in Neurovascular and Cardiovascular Systems. Journal of Stroke and Cerebrovascular Diseases. 2021; 30(1). DOI: 10.1016/j.jstrokecerebrovasdis.2020.105427
  82. Trypsteen W, Van Cleemput J, Snippenberg WV, Gerlo S, Vandekerckhove L. On the whereabouts of SARS-CoV-2 in the human body: A systematic review. PLoS Pathog. 2020; 16(10): e1009037. DOI: 10.1371/journal.ppat.1009037
  83. Kordzadeh-Kermani E, Khalili H, Karimzadeh I. Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19). Future Microbiology. 2020; 15(13): 1287305. DOI: 10.2217/fmb-2020-0110
  84. Deshmukh V, Motwani R, Kumar A, Kumari C, Raza K. Histopathological observations in COVID-19: A systematic review. J Clin Pathol; 2020. DOI: 10.1136/jclinpath-2020-206995
  85. Libby P. The Heart in COVID-19. JACC: Basic to Translational Science. 2020; 5(5): 53742. DOI: 10.1016/j.jacbts.2020.04.001
  86. Rivara MB, Bajwa EK, Januzzi JL, et al. Prognostic significance of elevated cardiac troponin-T levels in acute respiratory distress syndrome patients. PLoS One. 2012; 7(7): e40515. DOI: 10.1371/journal.pone.0040515
  87. Geng YJ, Wei ZY, Qian HY, et al. Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Cardiovasc Pathol. 2020; 47: 107228. DOI: 10.1016/j.carpath.2020.107228
  88. Kawakami R, Sakamoto A, Kawai K, et al. Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week. Journal of the American College of Cardiology. 2021; 77(3): 31425. DOI: 10.1016/j.jacc.2020.11.031
  89. Panigada M, Bottino N, Tagliabue P, et al. Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis. Journal of Thrombosis and Haemostasis. 2020; 18(7): 173842. DOI: 10.1111/jth.14850
  90. Siripanthong B, Nazarian S, Muser D, et al. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart rhythm. 2020; 17(9): 146371. DOI: 10.1016/j.hrthm.2020.05.001
  91. Caforio AL, Pankuweit S, Arbustini E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013; 34(33): 263648, 48a–48d. DOI: 10.1093/eurheartj/eht210
  92. Kociol RD, Cooper LT, Fang JC, et al. Recognition and Initial Management of Fulminant Myocarditis. Circulation. 2020; 141(6): e69e92. DOI: 10.1161/CIR.0000000000000745
  93. Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3): 26971. DOI: 10.1038/s41422-020-0282-0
  94. Singh B, Ryan H, Kredo T, Chaplin M, Fletcher T. Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19. Cochrane Database of Systematic Reviews. 2021; 2. DOI: 10.1002/14651858.CD013587.pub2
  95. Das RR, Jaiswal N, Dev N, Naik SS, Sankar J. Efficacy and Safety of Anti-malarial Drugs (Chloroquine and Hydroxy-Chloroquine) in Treatment of COVID-19 Infection: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2020; 7: 482. DOI: 10.3389/fmed.2020.00482
  96. Olasińska-Wiśniewska A, Olasiński J, Grajek S. Cardiovascular safety of antihistamines. Postepy Dermatol Alergol. 2014; 31(3): 1826. DOI: 10.5114/pdia.2014.43191
  97. Page RL, O’Bryant CL, Cheng D, et al. Drugs That May Cause or Exacerbate Heart Failure. Circulation. 2016; 134(6): e32e69. DOI: 10.1161/CIR.0000000000000426
  98. Bellissima BL, Tingle MD, Cicović A, Alawami M, Kenedi C. A systematic review of clozapine-induced myocarditis. Int J Cardiol. 2018; 259: 1229. DOI: 10.1016/j.ijcard.2017.12.102
  99. Ongoing Living Update of Potential COVID-19 Therapeutics: Summary of Rapid Systematic Reviews. Rapid Review [Internet]. PAHO; 2021 [cited 2021-02-08]. Retrieved from: https://iris.paho.org/handle/10665.2/52719.
  100. Cohen JB, Hanff TC, William P, et al. Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: A prospective, randomised, open-label trial. Lancet Respir Med; 2021. DOI: 10.1016/S2213-2600(20)30558-0
  101. Lopes RD, Macedo AVS, de Barros E Silva PGM, et al. Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial. JAMA. 2021; 325(3): 25464. DOI: 10.1001/jama.2020.25864
DOI: https://doi.org/10.5334/gh.1037 | Journal eISSN: 2211-8179
Language: English
Submitted on: Mar 22, 2021
Accepted on: Dec 18, 2021
Published on: Jan 12, 2022
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 Sasha Peiris, Pedro Ordunez, Donald DiPette, Raj Padwal, Pierre Ambrosi, Joao Toledo, Victoria Stanford, Thiago Lisboa, Sylvain Aldighieri, Ludovic Reveiz, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.