Characterization of 2,500 Patients with Heart Failure and Analysis of Their Optimal Medical Therapy: Insights from the AMERICCAASS Registry
By: Alex David Sotomayor-Julio, Sebastián Seni-Molina, Juliana María Gutiérrez-Posso, Juan Andrés Muñoz-Ordoñez, Valeria Azcárate-Rodríguez, Hoover O. León-Giraldo, Eduardo R. Perna, Víctor Rossel, Daniel Quesada-Chaves, Mario Speranza, Mark H. Drazner, Walter Alarco, Alexander Romero-Guerra, Gabriel Frago, Daniela García Brasca, Álvaro Mauricio Quintero-Ossa, Javier Galeano Figueredo, Milton Lubeck Herrera, Antonella A. Ferrer, Ruddy Miguel García Safadit, Freddy Pow-Chon-Long, Felix Nunura Arrese, Kwame van der Hilst, Silvia Carolina Lazo-Majano, Elisabeth Ashley Hardin, Orlando David Fernández-Flores, Gabriela Ormaechea-Gorricho, Luis Felipe Anhuaman-Atoche, Annia María Carrero-Vásquez, Andrés Ulate Retana, Pablo Hurtado Nuñez, Emilio Samael Peralta-López, Juan Esteban Gómez-Mesa and On Behalf of AMERICCAASS Research Group
References
- Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272–87. DOI: 10.1093/cvr/cvac013. Erratum in: Cardiovasc Res. 2023 Jun 13;119(6):1453.
- Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–858. DOI: 10.1016/S0140-6736(18)32279-7
- Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27(22):2725–36. DOI: 10.1093/eurheartj/ehl193
- Heidenreich PA, Albert NM, Allen LA, Bluemke DA, Butler J, Fonarow GC, et al. Forecasting the impact of heart failure in the United States. Circ Heart Fail. 2013;6(3):606–19. DOI: 10.1161/HHF.0b013e318291329a
- Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52. DOI: 10.1016/S0140-6736(04)17018-9
- Bowry ADK, Lewey J, Dugani SB, Choudhry NK. The burden of cardiovascular disease in low- and middle-income countries: Epidemiology and management. Can J Cardiol. 2015;31(9):1151–9. DOI: 10.1016/j.cjca.2015.06.028
- Jahangir E, Comandé D, Rubinstein A. Cardiovascular disease research in Latin America: A comparative bibliometric analysis. World J Cardiol. 2011;3(12):383–7. DOI: 10.4330/wjc.v3.i12.383
- Ciapponi A, Alcaraz A, Calderón M, Matta MG, Chaparro M, Soto N, et al. Burden of Heart Failure in Latin America: A systematic review and meta-analysis. Rev Espanola Cardiol. (English Edition). 2016;69(11):1051–60. DOI: 10.1016/j.rec.2016.04.054
- Speranza Sánchez MO, Quesada Chaves D, Castillo Chaves G, Lainez Sánchez L, Mora Tumminelli L, Brenes Umaña CD, et al. Registro nacional de insuficiencia cardíaca de Costa Rica. El estudio RENAIC CR. Rev. costarric. cardiol. [Internet]. 2017 Dec [cited 2025 Feb 26];19(1–2): 21–34. Available from:
http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-41422017000100021&lng=en . - Albuquerque DC de, Neto JD de S, Bacal F, Rohde LEP, Bernardez-Pereira S, Berwanger O, et al. I Brazilian Registry of Heart Failure – Clinical Aspects, Care Quality and Hospitalization Outcomes. Arq Bras Cardiol. 2015;104(6):433–42. DOI: 10.5935/abc.20150031
- Gómez-Mesa JE, Saldarriaga-Giraldo CI, Echeverría-Correa LE, Luna-Bonilla P. Registro colombiano de falla cardiaca (RECOLFACA): resultados. Rev Colomb Cardiol. 2021;334–44. Available at:
https://scc.org.co/wp-content/uploads/2018/10/Registro-colombiano-de-falla-cardiaca-RECOLFACA-resultados.pdf . - Thierer J, Perna ER, Marino J, Coronel ML, Barisani JL, Brasca DG, et al. Insuficiencia cardíaca crónica en Argentina. OFFICE IC AR, un registro conjunto de la Sociedad Argentina de Cardiología y de la Federación Argentina de Cardiología. Rev Argent Cardiol. 2022;90(1):15–24. Available at:
https://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1850-37482022000100015 . - Lescano A, Sorasio G, Soricetti J, Arakaki D, Coronel L, Cáceres L, et al. Registro Argentino de Insuficiencia Cardíaca Aguda (ARGEN-IC). Evaluación de cohorte parcial a 30 días. Rev Argent Cardiol. 2020;88(2):118–25. DOI: 10.7775/rac.es.v88.i2.17201
- Castro GP, Vukasovic RJL, Garcés SE, Sepúlveda ML, Ferrada KM, Alvarado OS. Insuficiencia cardíaca en hospitales chilenos: resultados del Registro Nacional de Insuficiencia Cardíaca, Grupo ICARO. Rev Médica Chile. 2004 Jun;132(6):655–62. DOI: 10.4067/S0034-98872004000600001
- Bocchi EA. Heart Failure in South America. Curr Cardiol Rev. 2013 May;9(2):147–56. DOI: 10.2174/1573403X11309020007
- Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, et al. Heart Failure in Africa, Asia, the Middle East and South America: The INTER-CHF study. Int J Cardiol. 2016 Feb 1;204:133–41. DOI: 10.1016/j.ijcard.2015.11.183
- Urina-Jassir M, Jaimes-Reyes MA, Martinez-Vernaza S, Urina-Triana M. The Need for Creating a Unified Knowledge of Cardiovascular Diseases in Latin America. Braz J Cardiovasc Surg. 2022;37(3):I–II. DOI: 10.21470/1678-9741-2022-0954
- McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2023 Oct 1;44(37):3627–39. DOI: 10.1093/eurheartj/ehad613
- McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2021 Sep 21;42(36):3599–3726. DOI: 10.1093/eurheartj/ehab368. Erratum in: Eur Heart J. 2021 Dec 21;42(48):4901. DOI: https://doi.org/10.1093/eurheartj/ehab670
- Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, et al. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022 Sep 22;387(12):1089–98. DOI: 10.1056/NEJMoa2206286
- Fatima K, Butler J, Fonarow GC. Residual risk in heart failure and the need for simultaneous implementation and innovation. Eur J Heart Fail. 2023 Sep;25(9):1477–80. DOI: 10.1002/ejhf.3005
- Gómez-Mesa JE, Gutiérrez-Posso JM, Escalante-Forero M, Córdoba-Melo BD, Cárdenas-Marín PA, Perna ER, et al. American Registry of Ambulatory or acutely decompensated heart failure (AMERICCAASS Registry): First 1000 patients. Clin Cardiol. 2023 Nov 30;47(2):
e24182 . DOI: 10.1002/clc.24182 - Gómez-Mesa JE, Gutiérrez-Posso JM, Escalante-Forero M, Eraso-Bolaños DE, Drazner MH, Quesada-Chaves D, et al. American registry of ambulatory and acute decompensated heart failure (AMERICCAASS registry): Rationale and design. ESC Heart Fail. 2024 Dec;11(6):3805–3813. DOI: 10.1002/ehf2.14965 (cited 2024 Aug 19). Available from:
https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.14965 . - Bragazzi NL, Zhong W, Shu J, Abu Much A, Lotan D, Grupper A, et al. Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017. Eur J Prev Cardiol. 2021 Dec 29;28(15):1682–90. DOI: 10.1093/eurjpc/zwaa147
- Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020 Aug;22(8):1342–56. DOI: 10.1002/ejhf.1858
- Regitz-Zagrosek V. Sex and Gender Differences in Heart Failure. Int J Heart Fail. 2020 Apr 13;2(3):157–81. DOI: 10.36628/ijhf.2020.0004
- Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, et al. Sex differences in heart failure. Eur Heart J. 2019 Dec 14;40(47):3859–3868c. DOI: 10.1093/eurheartj/ehz835
- Emmons-Bell S, Johnson C, Roth G. Prevalence, incidence and survival of heart failure: a systematic review. Heart Br Card Soc. 2022 Aug 11;108(17):1351–60. DOI: 10.1136/heartjnl-2021-320131
- Bellanca L, Linden S, Farmer R. Incidence and prevalence of heart failure in England: a descriptive analysis of linked primary and secondary care data – the PULSE study. BMC Cardiovasc Disord. 2023 Jul 26;23(1):374. DOI: 10.1186/s12872-023-03337-1
- Barasa A, Schaufelberger M, Lappas G, Swedberg K, Dellborg M, Rosengren A. Heart failure in young adults: 20-year trends in hospitalization, aetiology, and case fatality in Sweden. Eur Heart J. 2014 Jan 1;35(1):25–32. DOI: 10.1093/eurheartj/eht278
- Lecoeur E, Domengé O, Fayol A, Jannot AS, Hulot JS. Epidemiology of heart failure in young adults: a French nationwide cohort study. Eur Heart J. 2023 Feb 1;44(5):383–92. DOI: 10.1093/eurheartj/ehac651. Erratum in: Eur Heart J. 2024 Jul 9;45(26):2335. DOI: https://doi.org/10.1093/eurheartj/ehae18732.
- Christiansen MN, Køber L, Weeke P, Vasan RS, Jeppesen JL, Smith JG, et al. Age-Specific Trends in Incidence, Mortality, and Comorbidities of Heart Failure in Denmark, 1995 to 2012. Circulation. 2017 Mar 28;135(13):1214–23. DOI: 10.1161/CIRCULATIONAHA.116.025941
- Group BMJP. Age dependent associations of risk factors with heart failure: pooled population based cohort study. BMJ. 2021 Mar 23;372:
n461 . DOI: 10.1136/bmj.n461. Erratum in: BMJ. 2021 Apr 1;373:n880. DOI: https://doi.org/10.1136/bmj.n880 - Tromp J, Bamadhaj S, Cleland JGF, Angermann CE, Dahlstrom U, Ouwerkerk W, et al. Post-discharge prognosis of patients admitted to hospital for heart failure by world region, and national level of income and income disparity (REPORT-HF): a cohort study. Lancet Glob Health. 2020 Mar 1;8(3):e411–22. DOI: 10.1016/S2214-109X(20)30004-8. Erratum in: Lancet Glob Health. 2020 Aug;8(8):e1001. DOI: https://doi.org/10.1016/S2214-109X(20)30294-1. Erratum in: Lancet Glob Health. 2020 Aug;8(8):e1002. DOI: https://doi.org/10.1016/S2214-109X(20)30283-7
- Sedlar N, Lainscak M, Farkas J. Self-care perception and behaviour in patients with heart failure: A qualitative and quantitative study. ESC Heart Fail. 2021 Jun;8(3):2079–88. DOI: 10.1002/ehf2.13287
- Kamimura D, Cain LR, Mentz RJ, White WB, Blaha MJ, DeFilippis AP, et al. Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study. Circulation. 2018 Jun 12;137(24):2572–82. DOI: 10.1161/CIRCULATIONAHA.117.031912
- Rasoul D, Ajay A, Abdullah A, Mathew J, Lee Wei En B, Mashida K, et al. Alcohol and Heart Failure. Eur Cardiol. 2023;18:
e65 . DOI: 10.15420/ecr.2023.12 - Biddinger KJ, Emdin CA, Haas ME, Wang M, Hindy G, Ellinor PT, et al. Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease. JAMA Netw Open. 2022 Mar 25;5(3):
e223849 . DOI: 10.1001/jamanetworkopen.2022.3849. Erratum in: JAMA Netw Open. 2022 Apr 1;5(4):e2212024. DOI: https://doi.org/10.1001/jamanetworkopen.2022.12024 - Snow SC, Fonarow GC, Ladapo JA, Washington DL, Hoggatt KJ, Ziaeian B. National Rate of Tobacco and Substance Use Disorders Among Hospitalized Heart Failure Patients. Am J Med. 2019 Apr;132(4):478–488.e4. DOI: 10.1016/j.amjmed.2018.11.038
- Chun KH, Kang SM. Cardiac Rehabilitation in Heart Failure. Int J Heart Fail. 2021 Jan;3(1):1–14. DOI: 10.36628/ijhf.2020.0021
- Magaña-Serrano JA, Almahmeed W, Gomez E, Al-Shamiri M, Adgar D, Sosner P, et al. Prevalence of heart failure with preserved ejection fraction in Latin American, Middle Eastern, and North African Regions in the I PREFER study (Identification of Patients With Heart Failure and PREserved Systolic Function: an epidemiological regional study). Am J Cardiol. 2011 Nov 1;108(9):1289–96. DOI: 10.1016/j.amjcard.2011.06.044
- Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 3;145(18):e895–e1032. DOI: 10.1161/CIR.0000000000001063. Epub 2022 Apr 1. Erratum in: Circulation. 2022 May 3;145(18):e1033. DOI: https://doi.org/10.1161/CIR.0000000000001073. Erratum in: Circulation. 2022 Sep 27;146(13):e185. DOI: https://doi.org/10.1161/CIR.0000000000001097. Erratum in: Circulation. 2023 Apr 4;147(14):e674. DOI: https://doi.org/10.1161/CIR.0000000000001142
- Docherty KF, Bayes-Genis A, Butler J, Coats AJS, Drazner MH, Joyce E, et al. The four pillars of HFrEF therapy: is it time to treat heart failure regardless of ejection fraction? Eur Heart J Suppl. 2022 Dec 27;24(Suppl_L):L10–19. DOI: 10.1093/eurheartjsupp/suac113
- Zafeiropoulos S, Farmakis IT, Milioglou I, Doundoulakis I, Gorodeski EZ, Konstantinides SV, et al. Pharmacological Treatments in Heart Failure With Mildly Reduced and Preserved Ejection Fraction: Systematic Review and Network Meta-Analysis. JACC Heart Fail. 2024 Apr;12(4):616–27. DOI: 10.1016/j.jchf.2023.07.014
- Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, et al. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2024 Oct 23;391(16):1475–85. DOI: 10.1056/NEJMoa2407107
- Docherty KF, Henderson AD, Jhund PS, Claggett BL, Desai AS, Mueller K, et al. Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure with Mildly Reduced and Preserved Ejection Fraction: a Prespecified Analysis of The FINEARTS-HF Trial. Circulation. 2025;151(1):45–58. DOI: 10.1161/CIRCULATIONAHA.124.072011
- Anderson CE, Stewart CC. Rates of Adherence to Guideline Directed Medical Therapy in Heart Failure: Experience at an Academic Center. J Am Coll Cardiol. 2022 Mar 8;79(9, Supplement):459. DOI: 10.1016/S0735-1097(22)01450-4
- Greene SJ, Butler J, Albert NM, DeVore AD, Sharma PP, Duffy CI, et al. Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry. J Am Coll Cardiol. 2018 Jul 24;72(4):351–66. DOI: 10.1016/j.jacc.2018.04.070
- Jafri SH, Hushcha P, Dorbala P, Bousquet G, Lutfy C, Mellett L, et al. Use of Optimal Medical Therapy in Patients With Cardiovascular Disease Undergoing Cardiac Rehabilitation. Curr Probl Cardiol. 2024 Jan 1;49(1, Part A):
102058 . DOI: 10.1016/j.cpcardiol.2023.102058 - Tromp J, Ouwerkerk W, Teng THK, Cleland JGF, Bamadhaj S, Angermann CE, et al. Global disparities in prescription of guideline-recommended drugs for heart failure with reduced ejection fraction. Eur Heart J. 2022 Jun 14;43(23):2224–34. DOI: 10.1093/eurheartj/ehac103
- Sandhu AT, Kohsaka S, Turakhia MP, Lewis EF, Heidenreich PA. Evaluation of Quality of Care for US Veterans With Recent-Onset Heart Failure With Reduced Ejection Fraction. JAMA Cardiol. 2022 Feb 1;7(2):130–9. DOI: 10.1001/jamacardio.2021.4585
- Azizi Z, Golbus JR, Spaulding EM, Hwang PH, Ciminelli ALA, Lacar K, et al. Challenge of Optimizing Medical Therapy in Heart Failure: Unlocking the Potential of Digital Health and Patient Engagement. J Am Heart Assoc. 2024 Jan 16;13(2):
e030952 . DOI: 10.1161/JAHA.123.030952 - DeVore AD, Bosworth HB, Granger BB. Improving implementation of evidence-based therapies for heart failure. Clin Cardiol. 2022 Jun;45 Suppl 1(Suppl 1):S52–9. DOI: 10.1002/clc.23845
- DeFilippis EM, Fiuzat M. Putting the “Optimal” in Optimal Medical Therapy. JACC Heart Fail. 2021 Jan;9(1):39–41. DOI: 10.1016/j.jchf.2020.08.016
- Unverzagt S, Meyer G, Mittmann S, Samos FA, Unverzagt M, Prondzinsky R. Improving Treatment Adherence in Heart Failure. Dtsch Arzteblatt Int. 2016 Jun 24;113(25):423–30. DOI: 10.3238/arztebl.2016.0423
- Ruppar TM, Cooper PS, Mehr DR, Delgado JM, Dunbar-Jacob JM. Medication Adherence Interventions Improve Heart Failure Mortality and Readmission Rates: Systematic Review and Meta-Analysis of Controlled Trials. J Am Heart Assoc. 2016 Jun 17;5(6):
e002606 . DOI: 10.1161/JAHA.115.002606 - DeVore AD, Walsh MN, Vardeny O, Albert NM, Desai AS. Digital Solutions for the Optimization of Pharmacologic Therapy for Heart Failure. JACC Heart Fail. 2025 Jan 3;S2213-1779(24)00798-4. DOI: 10.1016/j.jchf.2024.10.014
DOI: https://doi.org/10.5334/gh.1418 | Journal eISSN: 2211-8179
Language: English
Submitted on: Nov 20, 2024
Accepted on: Feb 24, 2025
Published on: Mar 11, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
© 2025 Alex David Sotomayor-Julio, Sebastián Seni-Molina, Juliana María Gutiérrez-Posso, Juan Andrés Muñoz-Ordoñez, Valeria Azcárate-Rodríguez, Hoover O. León-Giraldo, Eduardo R. Perna, Víctor Rossel, Daniel Quesada-Chaves, Mario Speranza, Mark H. Drazner, Walter Alarco, Alexander Romero-Guerra, Gabriel Frago, Daniela García Brasca, Álvaro Mauricio Quintero-Ossa, Javier Galeano Figueredo, Milton Lubeck Herrera, Antonella A. Ferrer, Ruddy Miguel García Safadit, Freddy Pow-Chon-Long, Felix Nunura Arrese, Kwame van der Hilst, Silvia Carolina Lazo-Majano, Elisabeth Ashley Hardin, Orlando David Fernández-Flores, Gabriela Ormaechea-Gorricho, Luis Felipe Anhuaman-Atoche, Annia María Carrero-Vásquez, Andrés Ulate Retana, Pablo Hurtado Nuñez, Emilio Samael Peralta-López, Juan Esteban Gómez-Mesa, On Behalf of AMERICCAASS Research Group, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.