Construction and Verification of a Predictive Model for the Progression of Aortic Valve Calcification
References
- Bertazzo S, Gentleman E. Aortic valve calcification: a bone of contention. Eur Heart J. 2017;38(16):1189–1193. DOI: 10.1093/eurheartj/ehw071
- Bortnick AE, Xu S, Kim RS, Kestenbaum B, Ix JH, Jenny NS, et al. Biomarkers of mineral metabolism and progression of aortic valve and mitral annular calcification: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2019;285:79–86. DOI: 10.1016/j.atherosclerosis.2019.04.215
- Généreux P, Sharma RP, Cubeddu RJ, Aaron L, Abdelfattah OM, Koulogiannis KP, et al. The mortality burden of untreated aortic stenosis. J Am Coll Cardiol. 2023;82(22):2101–2109. DOI: 10.1016/j.jacc.2023.09.796
- Willemink MJ, Maret E, Moneghetti KJ, Kim JB, Haddad F, Kobayashi Y, et al. Incremental value of aortomitral continuity calcification for risk assessment after Transcatheter Aortic Valve Replacement. Radiol Cardiothorac Imaging. 2019;1(5):
e190067 . DOI: 10.1148/ryct.2019190067 - Ludwig S, Goßling A, Waldschmidt L, Linder M, Bhadra OD, Voigtländer L, et al. TAVR for low-flow, low-gradient aortic stenosis: prognostic impact of aortic valve calcification. Am Heart J. 2020;225:138–148. DOI: 10.1016/j.ahj.2020.03.013
- Owens DS, Budoff MJ, Katz R, Takasu J, Shavelle DM, Carr JJ, et al. Aortic valve calcium independently predicts coronary and cardiovascular events in a primary prevention population. JACC Cardiovasc Imaging. 2012;5(6):619–25. DOI: 10.1016/j.jcmg.2011.12.023
- Chan KL, Teo K, Dumesnil JG, Ni A, Tam J. Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation. 2010;121(2):306–14. DOI: 10.1161/CIRCULATIONAHA.109.900027
- Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB, et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med. 2005;352(23):2389–97. DOI: 10.1056/NEJMoa043876
- Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359(13):1343–56. DOI: 10.1056/NEJMoa0804602
- Dichtl W, Alber HF, Feuchtner GM, Hintringer F, Reinthaler M, Bartel T, et al. Prognosis and risk factors in patients with asymptomatic aortic stenosis and their modulation by atorvastatin (20 mg). Am J Cardiol. 2008;102(6):743–8. DOI: 10.1016/j.amjcard.2008.04.060
- Burgess S, Ference BA, Staley JR, Freitag DF, Mason AM, Nielsen SF, et al. Association of LPA variants with risk of coronary disease and the implications for lipoprotein(a)-lowering therapies: a Mendelian randomization analysis. JAMA Cardiol. 2018;3(7):619–627. DOI: 10.1001/jamacardio.2018.1470
- Welsh P, Welsh C, Celis-Morales CA, Brown R, Ho FK, Ferguson LD, et al. Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions. Eur J Prev Cardiol. 2022;28(18):1991–2000. DOI: 10.1093/eurjpc/zwaa063
- Brandenburg VM, Reinartz S, Kaesler N, Krüger T, Dirrichs T, Kramann R, et al. Slower progress of aortic valve calcification with vitamin K supplementation: results from a prospective interventional proof-of-concept study. Circulation. 2017;135(21):2081–2083. DOI: 10.1161/CIRCULATIONAHA.116.027011
- O’Brien KD, Probstfield JL, Caulfield MT, Nasir K, Takasu J, Shavelle DM, et al. Angiotensin-converting enzyme inhibitors and change in aortic valve calcium. Arch Intern Med. 2005;165(8):858–62. DOI: 10.1001/archinte.165.8.858
- Capoulade R, Clavel M-A, Mathieu P, Côté N, Dumesnil JG, Arsenault M, et al. Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis. Eur J Clin Invest. 2013;43(12):1262–72. DOI: 10.1111/eci.12169
- Poggianti E, Venneri L, Chubuchny V, Jambrik Z, Baroncini LA, Picano E. Aortic valve sclerosis is associated with systemic endothelial dysfunction. J Am Coll Cardiol. 2003;41(1):136–41. DOI: 10.1016/S0735-1097(02)02622-0
- Choi B, Lee S, Kim S-M, Lee E-J, Lee SR, Kim D-H, et al. Dipeptidyl peptidase-4 induces aortic valve calcification by inhibiting insulin-like growth factor-1 signaling in valvular interstitial cells. Circulation. 2017;135(20):1935–1950. DOI: 10.1161/CIRCULATIONAHA.116.024270
- Bäck M, Michel J-B. From organic and inorganic phosphates to valvular and vascular calcifications. Cardiovasc Res. 2021;117(9):2016–2029. DOI: 10.1093/cvr/cvab038
- Bild DE, Bluemke DA, Burke GL, Detrano R, Roux AVD, Folsom AR, et al. Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol. 2002;156(9):871–81. DOI: 10.1093/aje/kwf113
- Elmariah S, Delaney JAC, O’Brien KD, Budoff MJ, Vogel-Claussen J, Fuster V, et al. Bisphosphonate use and prevalence of valvular and vascular calcification in women MESA (the Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2010;56(21):1752–9. DOI: 10.1016/j.jacc.2010.05.050
- Li Z-H, Hao Q-Y, Zeng Y-H, Guo J-B, Li S-C, Gao J-W, et al. Remnant cholesterol and the risk of aortic valve calcium progression: insights from the MESA study. Cardiovasc Diabetol. 2024;23(1):20. DOI: 10.1186/s12933-023-02081-2
- Cheng FW, Ford NA, Wood AC, Tracy R. Avocado consumption and markers of inflammation: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Nutr. 2023;62(5):2105–2113. DOI: 10.1007/s00394-023-03134-8
- Ambale-Venkatesh B, Yang X, Wu CO, Liu K, Hundley WG, McClelland R, et al. Cardiovascular event prediction by machine learning: the Multi-Ethnic Study of Atherosclerosis. Circ Res. 2017;121(9):1092–1101. DOI: 10.1161/CIRCRESAHA.117.311312
- Yamamoto H, Shavelle D, Takasu J, Lu B, Mao SS, Fischer H, et al. Valvular and thoracic aortic calcium as a marker of the extent and severity of angiographic coronary artery disease. Am Heart J. 2003;146(1):153–9. DOI: 10.1016/S0002-8703(03)00105-4
- Bortnick AE, Buzkova P, Otvos JD, Jensen MK, Tsai MY, Budoff MJ, et al. High-density lipoprotein and long-term incidence and progression of Aortic Valve Calcification: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2022;42(10):1272–1282. DOI: 10.1161/ATVBAHA.122.318004
- Fashanu OE, Bizanti A, Al-Abdouh A, Zhao D, Budoff MJ, Thomas IC, et al. Progression of valvular calcification and risk of incident stroke: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2020;307:32–38. DOI: 10.1016/j.atherosclerosis.2020.06.009
- Rutkovskiy A, Malashicheva A, Sullivan G, Bogdanova M, Kostareva A, Stensløkken K-O, et al. Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification. J Am Heart Assoc. 2017;6(9). DOI: 10.1161/JAHA.117.006339
- Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, et al. Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis. J Am Coll Cardiol. 2019;73(17):2150–2162. DOI: 10.1016/j.jacc.2019.01.070
- Kaiser Y, van der Toorn JE, Singh SS, Zheng KH, Kavousi M, Sijbrands EJG, et al. Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification. Eur Heart J. 2022;43(39):3960–3967. DOI: 10.1093/eurheartj/ehac377
- Amoakwa K, Fashanu OE, Tibuakuu M, Zhao D, Guallar E, Whelton SP, et al. Resting heart rate and the incidence and progression of valvular calcium: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2018;273:45–52. DOI: 10.1016/j.atherosclerosis.2018.04.004
- Rogge BP, Cramariuc D, Lønnebakken MT, Gohlke-Bärwolf C, Chambers JB, Boman K, et al. Effect of overweight and obesity on cardiovascular events in asymptomatic aortic stenosis: a SEAS substudy (Simvastatin Ezetimibe in Aortic Stenosis). J Am Coll Cardiol. 2013;62(18):1683–1690. DOI: 10.1016/j.jacc.2013.04.081
- Briand M, Lemieux I, Dumesnil JG, Mathieu P, Cartier A, Després J-P, et al. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis. J Am Coll Cardiol. 2006;47(11):2229–36. DOI: 10.1016/j.jacc.2005.12.073
- Kaltoft M, Langsted A, Nordestgaard BG. Obesity as a causal risk factor for aortic valve stenosis. J Am Coll Cardiol. 2020;75(2):163–176. DOI: 10.1016/j.jacc.2019.10.050
- Kopytek M, Mazur P, Ząbczyk M, Undas A, Natorska J. Diabetes concomitant to aortic stenosis is associated with increased expression of NF-κB and more pronounced valve calcification. Diabetologia. 2021;64(11):2562–2574. DOI: 10.1007/s00125-021-05545-w
- Natorska J. Diabetes mellitus as a risk factor for aortic stenosis: from new mechanisms to clinical implications. Kardiol Pol. 2021;79(10):1060–1067. DOI: 10.33963/KP.a2021.0137
- Kamalesh M, Ng C, El Masry H, Eckert G, Sawada S. Does diabetes accelerate progression of calcific aortic stenosis? Eur J Echocardiogr. 2009;10(6):723–5. DOI: 10.1093/ejechocard/jep048
- Larsson SC, Wallin A, Håkansson N, Stackelberg O, Bäck M, Wolk A. Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases. Int J Cardiol. 2018;262:66–70. DOI: 10.1016/j.ijcard.2018.03.099
- Owens DS, Katz R, Takasu J, Kronmal R, Budoff MJ, O’Brien KD. Incidence and progression of aortic valve calcium in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Cardiol. 2010;105(5):701–8. DOI: 10.1016/j.amjcard.2009.10.071
DOI: https://doi.org/10.5334/gh.1473 | Journal eISSN: 2211-8179
Language: English
Submitted on: Jul 10, 2024
Accepted on: Sep 11, 2025
Published on: Sep 24, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
© 2025 Zhen Guo, Zhenyu Xiong, Chaoguang Xu, Jingjing He, Shaozhao Zhang, Rihua Huang, Menghui Liu, Jiaying Li, Xinxue Liao, Xiaodong Zhuang, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.