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Correction: Within-Trial Cost-Effectiveness Analysis of a Family-Based Structured Lifestyle Modification Intervention Program for Cardiovascular Risk Reduction: Results from the PROLIFIC Trial Cover

Correction: Within-Trial Cost-Effectiveness Analysis of a Family-Based Structured Lifestyle Modification Intervention Program for Cardiovascular Risk Reduction: Results from the PROLIFIC Trial

Open Access
|Oct 2025

Full Article

  1. The incremental cost per unit reduction in Framingham risk score was incorrectly reported as INR 1,26,569 (Int$7105). The correct value is INR 1,265.69 (Int$71.05). This affects the Framingham risk score incremental effectiveness and ICER values in Table 3, and changes in data shown in Table S2.

  2. The cost per percentage increase in optimal cardiac health, reported as INR 1,46,970 (Int$8,251), is at the group level. The per-person cost is INR 178.15 (Int$10.00).

Table 3

Incremental cost and cost-effectiveness of the intervention.

VARIABLESINCREMENTAL COSTINCREMENTAL EFFECTIVENESSICER
AGGREGATEPER PERSONAGGREGATEPER PERSONAGGREGATEPER PERSON
Glucose, mg/dl25,56,968 (143,545)3263.95 (183.23)–5471–6.79904–467.37 (26.24)–480.06(26.95)
HbA1c, %–25,94,418(145,647)3304.85(185.53)–1144.16–1.41869–2267.53(127.3)–2329.51(130.8)
Total Cholesterol, mg/dl25,56,968 (143,545)3263.95 (183.23)–14585–18.2615–175.31(9.84)–178.73(10.03)
LDL, mg/dl25,56,968 (143,545)3263.95 (183.23)–11,750.2–14.6113–217.61(12.22)–223.39(12.54)
HDL, mg/dl25,56,968 (143,545)3263.95 (183.23)5767.87.163697443.318(24.89)455.62(25.58)
Waist Circumference, cm22,96,308 (128,912)2959.93 (166.17)–3360.67–4.17584–683.29(38.36)–708.82(39.79)
BMI, kg/m222,99,232 (129,076)2946.96 (165.44)–1341.75–1.65666–1713.6(–96.2)–1778.85(99.86)
Systolic BP, mmHg23,11,108 (129,743)2943.72 (165.26)–4701–5.80374–491.62(–27.6)–507.21(28.47)
Diastolic BP, mmHg23,11,108 (129,743)2943.72 (165.26)–2573.5–3.17845–898.04(–50.41)–926.15(51.99)
Framingham Risk Score, %25,56,968 (143,545)3263.95 (183.23)–2059.08–2.579–1241.80 (69.71)–1265.69(71.05)
Table S2

Changes in Clinical Parameters.

VARIABLESAGGREGATE CHANGE (UC)PER-PERSON CHANGE (UC)AGGREGATE CHANGE (IG)PER-PERSON CHANGE (IG)
Fasting Glucose (mg/dL)5820.7106–4889–6.0884
HbA1c (%)270.20.3303–874.0–1.0884
Total Cholesterol (mg/dL)–4043–4.9365–18628–23.198
LDL (mg/dL)887.21.0833–10863–13.528
HDL (mg/dL)–785.8–0.959549826.204
Waist Circumference (cm)530.60.6471–2830.1–3.529
BMI (kg/m2)393.40.4785–948.4–1.178
Systolic BP (mmHg)952.51.1588–3748.5–4.645
Diastolic BP (mmHg)465.50.5663–2108–2.6121
Framingham Risk Score (%)–598.5–0.7307–2657.6–3.309

Competing Interests

DP and PJ received research grants from the US National Heart Lung and Blood Institute for a work-site-based cardiovascular risk reduction initiative (5R01HL125442-05). PJ also received research grants from the Australian National Health and Medical Research Council (1160283 and 1169766), the World Diabetes Federation (WDF-15–959), the National Institute for Health and Care Research, UK (204871), and the Indian Council of Medical Research for diabetes and hypertension risk reduction interventions. PJ is also a member of the editorial team for the journal but recused themselves from any editorial involvement with this article. All other authors declare no competing interests.

DOI: https://doi.org/10.5334/gh.1490 | Journal eISSN: 2211-8179
Language: English
Submitted on: Oct 9, 2025
Accepted on: Oct 9, 2025
Published on: Oct 21, 2025
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Ashis Samuel John, Sanjay Ganapathi, Sivadasanpillai Harikrishnan, Thoniparambil Ravindranathanpillai Lekha, Antony Stanley, Biju Soman, Thekkumkara Surendran Anish, Rujuta Hadaye, Jerin Jose Cherian, Nikhil Tandon, Dorairaj Prabhakaran, Panniyammakal Jeemon, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.