
Adiposity Phenotypes and Subclinical Atherosclerosis in Adults from Sub–Saharan Africa: An H3Africa AWI–Gen Study
By: Engelbert A. Nonterah, Michiel L. Bots, Abraham Oduro, Godfred Agongo, Cassandra C. Soo, Lisa K. Micklesfield, Felistas Mashinya, Palwendè R. Boua, Shukri F. Mohamed, Alisha N. Wade, Catherine Kyobutungi, Halidou Tinto, Shane A. Norris, Stephen M. Tollman, Michèle Ramsay, Diederick E. Grobbee, Kerstin Klipstein-Grobusch, Nigel J. Crowther and on behalf of the AWI–Gen and the H3Africa Consortium
References
- Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990–2015. J Am Coll Cardiol. 2017; 70(1): 1–25. DOI: 10.1016/j.jacc.2017.04.052
- NCD Risk Factor Collaboration (NCD-RisC) – Africa Working Group. Trends in obesity and diabetes across Africa from 1980–2014: An analysis of pooled population-based studies. Int J Epidemiol. 2017; 46(5): 1421–32.
- Ramsay M, Crowther NJ, Agongo G, Ali SA, Asiki G, Boua RP, et al. Regional and sex-specific variation in BMI distribution in four sub-Saharan African countries: The H3Africa AWI-Gen study. Glob Health Action. 2018; 11(sup2): 1556561. DOI: 10.1080/16549716.2018.1556561
- Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001; 104: 2746–53. DOI: 10.1161/hc4601.099487
- GBD 2015 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053): 1659–724. DOI: 10.1016/S0140-6736(16)31679-8
- NCD Risk Factor Collaboration (NCD-RisC). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature. 2019; 569(7755): 260–4. DOI: 10.1038/s41586-019-1171-x
- Libby P. Inflammation and atherosclerosis. Circulation. 2002; 105(9): 1135–43. DOI: 10.1161/hc0902.104353
- Kinlen D, Cody D, O’Shea D. Complications of obesity. QJM. 2018; 111(7): 437–43. DOI: 10.1093/qjmed/hcx152
- Wang H, Chen YE, Eitzman DT. Imaging body fat: Techniques and cardiometabolic implications. Arterioscler Thromb Vasc Biol. 2014; 34(10): 2217–23. DOI: 10.1161/ATVBAHA.114.303036
- Cornier MA, Despres JP, Davis N, Grossniklaus DA, Klein S, Lamarche B, et al. Assessing adiposity: A scientific statement from the American Heart Association. Circulation. 2011; 124(18): 1996–2019. DOI: 10.1161/CIR.0b013e318233bc6a
- Lee MJ, Wu Y, Fried SK. Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med. 2013; 34(1): 1–11. DOI: 10.1016/j.mam.2012.10.001
- Goedecke JH, Levitt NS, Lambert EV, Utzschneider KM, Faulenbach MV, Dave JA, et al. Differential effects of abdominal adipose tissue distribution on insulin sensitivity in black and white South African women. Obesity (Silver Spring). 2009; 17(8): 1506–12. DOI: 10.1038/oby.2009.73
- Sumner AE, Micklesfield LK, Ricks M, Tambay AV, Avila NA, Thomas F, et al. Waist circumference, BMI, and visceral adipose tissue in white women and women of African descent. Obesity (Silver Spring). 2011; 19(3): 671–4. DOI: 10.1038/oby.2010.201
- Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013; 31(7): 1281–357. DOI: 10.1097/01.hjh.0000431740.32696.cc
- O’Leary DH, Bots ML. Imaging of atherosclerosis: Carotid intima–media thickness. Eur Heart J. 2010; 31(14): 1682–9. DOI: 10.1093/eurheartj/ehq185
- Ruijter HMD, Peters SAE, Anderson TJ, Britton AR, Dekker JM, Eijkemans MJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: A meta-analysis. JAMA. 2012; 308(8): 796–803. DOI: 10.1001/jama.2012.9630
- Chen LY, Leening MJ, Norby FL, Roetker NS, Hofman A, Franco OH, et al. Carotid intima-media thickness and arterial stiffness and the risk of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study, Multi–Ethnic Study of Atherosclerosis (MESA), and the Rotterdam Study. J Am Heart Assoc. 2016; 5(5). DOI: 10.1161/JAHA.115.002907
- Jin-Kee P, Hyuntae P, Kwi-Baek K. The relationship between distribution of body fat mass and carotid artery intima-media thickness in Korean older adults. J Phys Ther Sci. 2015; 27(10): 3141–6. DOI: 10.1589/jpts.10.3141
- Kawamoto R, Ohtsuka N, Ninomiya D, Nakamura S. Association of obesity and visceral fat distribution with intima-media thickness of carotid arteries in middle-aged and older persons. Internal Medicine. 2008; 47(3): 143–9. DOI: 10.2169/internalmedicine.47.0478
- Oike M, Yokokawa H, Fukuda H, Haniu T, Oka F, Hisaoka T, et al. Association between abdominal fat distribution and atherosclerotic changes in the carotid artery. Obes Res Clin Pract. 2014; 8(5): e448–58. DOI: 10.1016/j.orcp.2013.09.002
- Lin A, Lacy ME, Eaton C, Correa A, Wu W-C. Inflammatory obesity phenotypes, gender effects and subclinical atherosclerosis in African Americans: The Jackson Heart Study. Arterioscler Thromb Vasc Biol. 2016; 36(12): 2431–8. DOI: 10.1161/ATVBAHA.116.307728
- Ramsay M, Sankoh O, as members of the AWIGen study and the H3Africa Consortium. African partnerships through the H3Africa Consortium bring a genomic dimension to longitudinal population studies on the continent. Int J Epidemiol. 2016; 45(2): 305–8. DOI: 10.1093/ije/dyv187
- Ramsay M, Crowther NJ, Tambo E, Agongo G, Baloyi V, Dikotope S, et al. H3Africa AWI-Gen collaborative centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries. Global Health, Epidemiology and Genomics. 2016; 1(e20): 1–13. DOI: 10.1017/gheg.2016.17
- Ali SA, Soo C, Agongo G, Alberts M, Amenga-Etego L, Boua RP, et al. Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study. Glob Health Action. 2018; 11(sup2): 1507133. DOI: 10.1080/16549716.2018.1507133
- Richter L, Norris S, Pettifor J, Yach D, Cameron N. Cohort profile: Mandela’s children: The 1990 Birth to twenty study in South Africa. Int J Epidemiol. 2007; 36(3): 504–11. DOI: 10.1093/ije/dym016
- Gomez-Olive FX, Montana L, Wagner RG, Kabudula CW, Rohr JK, Kahn K, et al. Cohort Profile: Health and ageing in Africa: A longitudinal study of an INDEPTH community in South Africa (HAALSI). Int J Epidemiol. 2018 (1464–3685 (Electronic)). DOI: 10.1093/ije/dyx247
- Alberts M, Dikotope SA, Choma SR, Masemola ML, Modjadji SEP, Mashinya F, et al. Health & demographic surveillance system profile: The dikgale health and demographic surveillance system. International Journal of Epidemiology. 2015; 44(5): 1565–71. DOI: 10.1093/ije/dyv157
- Beguy D, Elung’ata P, Mberu B, Oduor C, Wamukoya M, Nganyi B, et al. Health & demographic surveillance system rofile: The Nairobi Urban Health and Demographic Surveillance System (NUHDSS). Int J Epidemiol. 2015; 44(2): 462–71. DOI: 10.1093/ije/dyu251
- Derra K, Rouamba E, Kazienga A, Ouedraogo S, Tahita MC, Sorgho H, et al. Profile: Nanoro health and demographic surveillance system. Int J Epidemiol. 2012; 41(5): 1293–301. DOI: 10.1093/ije/dys159
- Oduro AR, Wak G, Azongo D, Debpuur C, Wontuo P, Kondayire F, et al. Profile of the navrongo health and demographic surveillance system. Int J Epidemiol. 2012; 41(4): 968–76. DOI: 10.1093/ije/dys111
- Dogan S, Plantinga Y, Crouse JR, Evans GW, Raichlen JS, O’Leary DH, et al. Algorithms to measure carotid intima-media thickness in trials: A comparison of reproducibility, rate of progression and treatment effect. J Hypertens. 2011; 29(11): 2181–93. DOI: 10.1097/HJH.0b013e32834b0eba
- Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. Mannheim carotid intima-media thickness and plaque consensus (2004–2006–2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis. 2012; 34(4): 290–6. DOI: 10.1159/000343145
- Nambi V, Chambless L, He M, Folsom AR, Mosley T, Boerwinkle E, et al. Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) study. Eur Heart J. 2012; 33(2): 183–90. DOI: 10.1093/eurheartj/ehr192
- Stolk RP, Meijer R, Mali WP, Grobbee DE, van der Graaf Y. Ultrasound measurements of intraabdominal fat estimate the metabolic syndrome better than do measurements of waist circumference. Am J Clin Nutr. 2003; 77(4): 857–60. DOI: 10.1093/ajcn/77.4.857
- De Lucia Rolfe E, Norris SA, Sleigh A, Brage S, Dunger DB, Stolk RP, et al. Validation of ultrasound estimates of visceral fat in black South African adolescents. Obesity. 2011; 19(9): 1892–7. DOI: 10.1038/oby.2011.213
- Riley RD, Lambert PC, Abo-Zaid G. Meta-analysis of individual participant data: Rationale, conduct, and reporting. BMJ. 2010; 340: c221. DOI: 10.1136/bmj.c221
- Gast KB, den Heijer M, Smit JW, Widya RL, Lamb HJ, de Roos A, et al. Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study. Atherosclerosis. 2015; 241(2): 547–54. DOI: 10.1016/j.atherosclerosis.2015.05.026
- Wildman RP, Janssen I, Khan UI, Thurston R, Barinas-Mitchell E, El Khoudary SR, et al. Subcutaneous adipose tissue in relation to subclinical atherosclerosis and cardiometabolic risk factors in midlife women. Am J Clin Nutr. 2011; 93(4): 719–26. DOI: 10.3945/ajcn.110.007153
- Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol. 2007; 27(5): 996–1003. DOI: 10.1161/ATVBAHA.106.131755
- Mudie K, Lawlor DA, Pearce N, Crampin A, Tomlinson L, Tafatatha T, et al. How does the association of general and central adiposity with glycaemia and blood pressure differ by gender and area of residence in a Malawian population: A cross-sectional study. Int J Epidemiol. 2018; 47(3): 887–98. DOI: 10.1093/ije/dyy047
- Sinabulya I, Kayima J, Longenecker C, Luwedde M, Semitala F, Kambugu A, et al. Subclinical atherosclerosis among HIV-infected adults attending HIV/AIDS care at two large ambulatory HIV clinics in Uganda. PLoS One. 2014; 9(2):
e89537 . DOI: 10.1371/journal.pone.0089537 - van der Merwe MT, Crowther NJ, Schlaphoff GP, Gray IP, Joffe BI, Lonnroth PN. Evidence for insulin resistance in black women from South Africa. Int J Obes Relat Metab Disord. 2000; 24(10): 1340–6. DOI: 10.1038/sj.ijo.0801416
- Waisberg R, Paiker JE, Crowther NJ. Adipokine serum concentrations, anthropometric measurements and socio-economic status in two ethnic groups with different prevalence levels for cardiovascular diseases and type 2 diabetes. Horm Metab Res. 2011; 43(9): 660–6. DOI: 10.1055/s-0031-1283139
- Lovren F, Teoh H, Verma S. Obesity and atherosclerosis: Mechanistic insights. Can J Cardiol. 2015; 31(2): 177–83. DOI: 10.1016/j.cjca.2014.11.031
- Narumi H, Yoshida K, Hashimoto N, Umehara I, Funabashi N, Yoshida S, et al. Increased subcutaneous fat accumulation has a protective role against subclinical atherosclerosis in asymptomatic subjects undergoing general health screening. International Journal of Cardiology. 2009; 135(2): 150–5. DOI: 10.1016/j.ijcard.2008.03.044
- Bouchi R, Takeuchi T, Akihisa M, Ohara N, Nakano Y, Nishitani R, et al. High visceral fat with low subcutaneous fat accumulation as a determinant of atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2015; 14: 136. DOI: 10.1186/s12933-015-0302-4
- Chen P, Hou X, Hu G, Wei L, Jiao L, Wang H, et al. Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes? Cardiovasc Diabetol. 2018; 17(1): 93. DOI: 10.1186/s12933-018-0734-8
- Porter SA, Massaro JM, Hoffmann U, Vasan RS, O’Donnel CJ, Fox CS. Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care. 2009; 32(6): 1068–75. DOI: 10.2337/dc08-2280
- Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia. 2002; 45(9): 1201–10. DOI: 10.1007/s00125-002-0873-y
- Kohli S, Sniderman AD, Tchernof A, Lear SA. Ethnic-specific differences in abdominal subcutaneous adipose tissue compartments. Obesity (Silver Spring). 2010; 18(11): 2177–83. DOI: 10.1038/oby.2010.94
- Marinou K, Hodson L, Vasan SK, Fielding BA, Banerjee R, Brismar K, et al. Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men. Diabetes Care. 2014; 37(3): 821–9. DOI: 10.2337/dc13-1353
- Wu TW, Hung CL, Liu CC, Wu YJ, Wang LY, Yeh HI. Associations of cardiovascular risk factors with carotid intima-media thickness in middle-age adults and elders. J Atheroscler Thromb. 2017; 24(7): 677–86. DOI: 10.5551/jat.37895
- Chang E, Varghese M, Singer K. Gender and sex differences in adipose tissue. Curr Diab Rep. 2018; 18(9): 69. DOI: 10.1007/s11892-018-1031-3
DOI: https://doi.org/10.5334/gh.863 | Journal eISSN: 2211-8179
Language: English
Submitted on: Jul 7, 2020
Accepted on: Feb 25, 2021
Published on: Mar 19, 2021
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
© 2021 Engelbert A. Nonterah, Michiel L. Bots, Abraham Oduro, Godfred Agongo, Cassandra C. Soo, Lisa K. Micklesfield, Felistas Mashinya, Palwendè R. Boua, Shukri F. Mohamed, Alisha N. Wade, Catherine Kyobutungi, Halidou Tinto, Shane A. Norris, Stephen M. Tollman, Michèle Ramsay, Diederick E. Grobbee, Kerstin Klipstein-Grobusch, Nigel J. Crowther, on behalf of the AWI–Gen and the H3Africa Consortium, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.